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Impaired right and left ventricular function in asymptomatic children with repaired tetralogy of Fallot by two-dimensional speckle tracking echocardiography study.
Echocardiography. 2015 Jan; 32(1):135-43.E

Abstract

BACKGROUND

Early detection of right ventricular (RV) and left ventricular (LV) dysfunction in patients with repaired tetralogy of Fallot (TOF) is essential because dysfunction is correlated with a poor clinical outcome. The aim of this study was to assess RV and LV function in asymptomatic children with repaired TOF by two-dimensional ultrasound speckle tracking echocardiography (STE).

METHODS

Fifty-six asymptomatic children with a preserved biventricular ejection fraction (EF) after repair of TOF and 35 healthy control subjects were studied. RV and LV strain and strain rate were measured by STE. RVEF and pulmonary regurgitation (PR) were assessed using cardiac magnetic resonance imaging.

RESULTS

Compared with the control subjects, RV regional longitudinal strain and strain rate and global longitudinal strain (GLS) and strain rate (GLSR) were impaired in children with repaired TOF. Likewise, LV circumferential and radial strain and strain rate were reduced in patients with TOF. In contrast, longitudinal strain and strain rate did not differ between the groups. RV and LV GLSR were correlated with postoperative follow-up period (r1 = -0.44; r2 = -0.48). RV GLS and GLSR were associated with RVEF (r1 = 0.64; r2 = 0.60) and PR (r1 = -0.48; r2 = -0.49). LV circumferential strain rate was related to PR (r = -0.45).

CONCLUSIONS

STE can identify abnormalities that may represent early impairment of RV and LV systolic function in postoperative TOF patients with a preserved EF. PR is associated with decreased biventricular performance in repaired patients. STE-derived strain and strain rate may be useful indices for detecting the early deterioration of biventricular performance in patients with TOF.

Authors+Show Affiliations

Department of Ultrasonography, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24661011

Citation

Li, Yuman, et al. "Impaired Right and Left Ventricular Function in Asymptomatic Children With Repaired Tetralogy of Fallot By Two-dimensional Speckle Tracking Echocardiography Study." Echocardiography (Mount Kisco, N.Y.), vol. 32, no. 1, 2015, pp. 135-43.
Li Y, Xie M, Wang X, et al. Impaired right and left ventricular function in asymptomatic children with repaired tetralogy of Fallot by two-dimensional speckle tracking echocardiography study. Echocardiography. 2015;32(1):135-43.
Li, Y., Xie, M., Wang, X., Lu, Q., Zhang, L., & Ren, P. (2015). Impaired right and left ventricular function in asymptomatic children with repaired tetralogy of Fallot by two-dimensional speckle tracking echocardiography study. Echocardiography (Mount Kisco, N.Y.), 32(1), 135-43. https://doi.org/10.1111/echo.12581
Li Y, et al. Impaired Right and Left Ventricular Function in Asymptomatic Children With Repaired Tetralogy of Fallot By Two-dimensional Speckle Tracking Echocardiography Study. Echocardiography. 2015;32(1):135-43. PubMed PMID: 24661011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired right and left ventricular function in asymptomatic children with repaired tetralogy of Fallot by two-dimensional speckle tracking echocardiography study. AU - Li,Yuman, AU - Xie,Mingxing, AU - Wang,Xinfang, AU - Lu,Qing, AU - Zhang,Li, AU - Ren,Pingping, Y1 - 2014/03/25/ PY - 2014/3/26/entrez PY - 2014/3/26/pubmed PY - 2015/9/16/medline KW - echocardiography KW - left ventricular function KW - right ventricular function KW - strain-strain rate KW - tetralogy of Fallot SP - 135 EP - 43 JF - Echocardiography (Mount Kisco, N.Y.) JO - Echocardiography VL - 32 IS - 1 N2 - BACKGROUND: Early detection of right ventricular (RV) and left ventricular (LV) dysfunction in patients with repaired tetralogy of Fallot (TOF) is essential because dysfunction is correlated with a poor clinical outcome. The aim of this study was to assess RV and LV function in asymptomatic children with repaired TOF by two-dimensional ultrasound speckle tracking echocardiography (STE). METHODS: Fifty-six asymptomatic children with a preserved biventricular ejection fraction (EF) after repair of TOF and 35 healthy control subjects were studied. RV and LV strain and strain rate were measured by STE. RVEF and pulmonary regurgitation (PR) were assessed using cardiac magnetic resonance imaging. RESULTS: Compared with the control subjects, RV regional longitudinal strain and strain rate and global longitudinal strain (GLS) and strain rate (GLSR) were impaired in children with repaired TOF. Likewise, LV circumferential and radial strain and strain rate were reduced in patients with TOF. In contrast, longitudinal strain and strain rate did not differ between the groups. RV and LV GLSR were correlated with postoperative follow-up period (r1 = -0.44; r2 = -0.48). RV GLS and GLSR were associated with RVEF (r1 = 0.64; r2 = 0.60) and PR (r1 = -0.48; r2 = -0.49). LV circumferential strain rate was related to PR (r = -0.45). CONCLUSIONS: STE can identify abnormalities that may represent early impairment of RV and LV systolic function in postoperative TOF patients with a preserved EF. PR is associated with decreased biventricular performance in repaired patients. STE-derived strain and strain rate may be useful indices for detecting the early deterioration of biventricular performance in patients with TOF. SN - 1540-8175 UR - https://www.unboundmedicine.com/medline/citation/24661011/Impaired_right_and_left_ventricular_function_in_asymptomatic_children_with_repaired_tetralogy_of_Fallot_by_two_dimensional_speckle_tracking_echocardiography_study_ L2 - https://doi.org/10.1111/echo.12581 DB - PRIME DP - Unbound Medicine ER -