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Prevalence of irritable bowel syndrome and functional dyspepsia, overlapping symptoms, and associated factors in a general population of Bangladesh.
Indian J Gastroenterol. 2014 May; 33(3):265-73.IJ

Abstract

BACKGROUND

This community-based survey aimed to find out the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), overlapping symptoms, and associated factors for overlap.

METHOD

By cluster sampling method, 3,000 (1,523 male) randomly selected adult subjects in the Sylhet district of Bangladesh were interviewed by a questionnaire based on ROME III criteria. Multivariate logistic regression analyses were done to find out the factors for overlap with significance level set at ≤0.05.

RESULTS

The mean age of the study population was 33.9 ± 16.4 years. Prevalence of IBS and FD and IBS-FD were 12.9 % (n = 387), 8.3 % (n = 249), and 3.5 % (n = 105), respectively. Approximately 27.1 % of IBS patients and 42.1 % of FD patients had overlapping IBS-FD. The odds ratio for IBS-FD overlap was 6.3 (95 % CI, 4.8-8.4). Mean age (p = 0.011) and epigastric pain (p = 0.002) were more in overlap patients than FD alone, whereas epigastric pain syndrome subtype (p < 0.009) was more prevalent in lone FD subjects. In the multivariate logistic analysis, early satiety (OR, 3.0; 95 % CI, 1.2-7.5; p = 0.018) and epigastric pain (OR, 14.5; 95 % CI, 5.0-42.1; p = 0.000) in FD patients appeared as independent risk factors for overlap. Bloating (p = 0.026), <3 stools per week (p = 0.050), abdominal pain reduced by defecation (p = 0.002), abdominal pain severity score (p = 0.004), and overall symptom frequency score (p = 0.000) were more in overlap patients than IBS-alone patients. In IBS patients, bloating (OR, 3.6; CI, 2.0-6.5; p = 0.000) was found as potential symptom associated with IBS-FD overlap.

CONCLUSION

FD was a less prevalent disorder than IBS in our community, and significant overlap existed between the two disorders. Early satiety, epigastric pain, and bloating were important factors associated with overlap.

Authors+Show Affiliations

Department of Gastroenterology, Enam Medical College, Dhaka, 1340, Bangladesh, irinperveen@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24664445

Citation

Perveen, Irin, et al. "Prevalence of Irritable Bowel Syndrome and Functional Dyspepsia, Overlapping Symptoms, and Associated Factors in a General Population of Bangladesh." Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, vol. 33, no. 3, 2014, pp. 265-73.
Perveen I, Rahman MM, Saha M, et al. Prevalence of irritable bowel syndrome and functional dyspepsia, overlapping symptoms, and associated factors in a general population of Bangladesh. Indian J Gastroenterol. 2014;33(3):265-73.
Perveen, I., Rahman, M. M., Saha, M., Rahman, M. M., & Hasan, M. Q. (2014). Prevalence of irritable bowel syndrome and functional dyspepsia, overlapping symptoms, and associated factors in a general population of Bangladesh. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, 33(3), 265-73. https://doi.org/10.1007/s12664-014-0447-1
Perveen I, et al. Prevalence of Irritable Bowel Syndrome and Functional Dyspepsia, Overlapping Symptoms, and Associated Factors in a General Population of Bangladesh. Indian J Gastroenterol. 2014;33(3):265-73. PubMed PMID: 24664445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of irritable bowel syndrome and functional dyspepsia, overlapping symptoms, and associated factors in a general population of Bangladesh. AU - Perveen,Irin, AU - Rahman,Mufti Munsurar, AU - Saha,Madhusudan, AU - Rahman,Mohammad Masudur, AU - Hasan,Mohammad Quamrul, Y1 - 2014/03/26/ PY - 2013/07/31/received PY - 2014/02/12/accepted PY - 2014/3/26/entrez PY - 2014/3/26/pubmed PY - 2015/8/19/medline SP - 265 EP - 73 JF - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JO - Indian J Gastroenterol VL - 33 IS - 3 N2 - BACKGROUND: This community-based survey aimed to find out the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), overlapping symptoms, and associated factors for overlap. METHOD: By cluster sampling method, 3,000 (1,523 male) randomly selected adult subjects in the Sylhet district of Bangladesh were interviewed by a questionnaire based on ROME III criteria. Multivariate logistic regression analyses were done to find out the factors for overlap with significance level set at ≤0.05. RESULTS: The mean age of the study population was 33.9 ± 16.4 years. Prevalence of IBS and FD and IBS-FD were 12.9 % (n = 387), 8.3 % (n = 249), and 3.5 % (n = 105), respectively. Approximately 27.1 % of IBS patients and 42.1 % of FD patients had overlapping IBS-FD. The odds ratio for IBS-FD overlap was 6.3 (95 % CI, 4.8-8.4). Mean age (p = 0.011) and epigastric pain (p = 0.002) were more in overlap patients than FD alone, whereas epigastric pain syndrome subtype (p < 0.009) was more prevalent in lone FD subjects. In the multivariate logistic analysis, early satiety (OR, 3.0; 95 % CI, 1.2-7.5; p = 0.018) and epigastric pain (OR, 14.5; 95 % CI, 5.0-42.1; p = 0.000) in FD patients appeared as independent risk factors for overlap. Bloating (p = 0.026), <3 stools per week (p = 0.050), abdominal pain reduced by defecation (p = 0.002), abdominal pain severity score (p = 0.004), and overall symptom frequency score (p = 0.000) were more in overlap patients than IBS-alone patients. In IBS patients, bloating (OR, 3.6; CI, 2.0-6.5; p = 0.000) was found as potential symptom associated with IBS-FD overlap. CONCLUSION: FD was a less prevalent disorder than IBS in our community, and significant overlap existed between the two disorders. Early satiety, epigastric pain, and bloating were important factors associated with overlap. SN - 0975-0711 UR - https://www.unboundmedicine.com/medline/citation/24664445/Prevalence_of_irritable_bowel_syndrome_and_functional_dyspepsia_overlapping_symptoms_and_associated_factors_in_a_general_population_of_Bangladesh_ L2 - https://dx.doi.org/10.1007/s12664-014-0447-1 DB - PRIME DP - Unbound Medicine ER -