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Percutaneous mitral valve repair with the MitraClip system according to the predicted risk by the logistic EuroSCORE: preliminary results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry.
Catheter Cardiovasc Interv. 2014 Oct 01; 84(4):591-8.CC

Abstract

OBJECTIVE

To evaluate in-hospital and short-term outcomes of percutaneous mitral valve repair according to patients' logistic EuroSCORE (logEuroSCORE) in a multicenter registry

BACKGROUND

The logEuroSCORE is an established tool to predict the risk of mortality during cardiac surgery. In high-risk patients percutaneous mitral valve repair with the MitraClip system represents a less-invasive alternative

METHODS

Data from 1002 patients, who underwent percutaneous mitral valve repair with the MitraClip system, were analyzed in the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. A logEuroSCORE (mortality risk in %) ≥ 20 was considered high risk

RESULTS

Of all patients, 557 (55.6%) had a logEuroSCORE ≥ 20. Implantation of the MitraClip was successful in 95.5 % (942/986) patients. Moderate residual mitral valve regurgitation was more often detected in patients with a logEuroSCORE ≥ 20 (23.8% vs. 17.1%, respectively, P < 0.05). In patients with a logEuroSCORE ≥ 20 the procedural complication rate was 8.9% (vs. 6.4, n.s.) and the in-hospital MACCE rate 4.9% (vs. 1.4% P < 0.01). The in-hospital mortality rate in patients with a logEuroSCORE ≥ 20 and logEuroSCORE < 20 was 4.3 and 1.1%, respectively (P ≤ 0.01) CONCLUSION: Percutaneous mitral valve repair with the MitraClip system is feasible in patients with a logEuroSCORE ≥ 20 with similar procedural results compared to patients with lower predicted risk. Although mortality was four times higher than in patients with logEuroSCORE < 20, mortality in high risk patients was lower than predicted. In those with a logEuroSCORE ≥ 20, moderate residual mitral valve regurgitation was more frequent.

Authors+Show Affiliations

CardioVascular Center Frankfurt, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24664460

Citation

Wiebe, Jens, et al. "Percutaneous Mitral Valve Repair With the MitraClip System According to the Predicted Risk By the Logistic EuroSCORE: Preliminary Results From the German Transcatheter Mitral Valve Interventions (TRAMI) Registry." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, vol. 84, no. 4, 2014, pp. 591-8.
Wiebe J, Franke J, Lubos E, et al. Percutaneous mitral valve repair with the MitraClip system according to the predicted risk by the logistic EuroSCORE: preliminary results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. Catheter Cardiovasc Interv. 2014;84(4):591-8.
Wiebe, J., Franke, J., Lubos, E., Boekstegers, P., Schillinger, W., Ouarrak, T., May, A. E., Eggebrecht, H., Kuck, K. H., Baldus, S., Senges, J., & Sievert, H. (2014). Percutaneous mitral valve repair with the MitraClip system according to the predicted risk by the logistic EuroSCORE: preliminary results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, 84(4), 591-8. https://doi.org/10.1002/ccd.25493
Wiebe J, et al. Percutaneous Mitral Valve Repair With the MitraClip System According to the Predicted Risk By the Logistic EuroSCORE: Preliminary Results From the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. Catheter Cardiovasc Interv. 2014 Oct 1;84(4):591-8. PubMed PMID: 24664460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Percutaneous mitral valve repair with the MitraClip system according to the predicted risk by the logistic EuroSCORE: preliminary results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. AU - Wiebe,Jens, AU - Franke,Jennifer, AU - Lubos,Edith, AU - Boekstegers,Peter, AU - Schillinger,Wolfgang, AU - Ouarrak,Taoufik, AU - May,Andreas E, AU - Eggebrecht,Holger, AU - Kuck,Karl-Heinz, AU - Baldus,Stephan, AU - Senges,Jochen, AU - Sievert,Horst, AU - ,, Y1 - 2014/04/30/ PY - 2014/01/27/received PY - 2014/03/12/accepted PY - 2014/3/26/entrez PY - 2014/3/26/pubmed PY - 2015/6/9/medline KW - MitraClip KW - inoperable KW - logistic EuroScore KW - mitral valve regurgitation KW - percutaneous mitral valve repair SP - 591 EP - 8 JF - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JO - Catheter Cardiovasc Interv VL - 84 IS - 4 N2 - OBJECTIVE: To evaluate in-hospital and short-term outcomes of percutaneous mitral valve repair according to patients' logistic EuroSCORE (logEuroSCORE) in a multicenter registry BACKGROUND: The logEuroSCORE is an established tool to predict the risk of mortality during cardiac surgery. In high-risk patients percutaneous mitral valve repair with the MitraClip system represents a less-invasive alternative METHODS: Data from 1002 patients, who underwent percutaneous mitral valve repair with the MitraClip system, were analyzed in the German Transcatheter Mitral Valve Interventions (TRAMI) Registry. A logEuroSCORE (mortality risk in %) ≥ 20 was considered high risk RESULTS: Of all patients, 557 (55.6%) had a logEuroSCORE ≥ 20. Implantation of the MitraClip was successful in 95.5 % (942/986) patients. Moderate residual mitral valve regurgitation was more often detected in patients with a logEuroSCORE ≥ 20 (23.8% vs. 17.1%, respectively, P < 0.05). In patients with a logEuroSCORE ≥ 20 the procedural complication rate was 8.9% (vs. 6.4, n.s.) and the in-hospital MACCE rate 4.9% (vs. 1.4% P < 0.01). The in-hospital mortality rate in patients with a logEuroSCORE ≥ 20 and logEuroSCORE < 20 was 4.3 and 1.1%, respectively (P ≤ 0.01) CONCLUSION: Percutaneous mitral valve repair with the MitraClip system is feasible in patients with a logEuroSCORE ≥ 20 with similar procedural results compared to patients with lower predicted risk. Although mortality was four times higher than in patients with logEuroSCORE < 20, mortality in high risk patients was lower than predicted. In those with a logEuroSCORE ≥ 20, moderate residual mitral valve regurgitation was more frequent. SN - 1522-726X UR - https://www.unboundmedicine.com/medline/citation/24664460/Percutaneous_mitral_valve_repair_with_the_MitraClip_system_according_to_the_predicted_risk_by_the_logistic_EuroSCORE:_preliminary_results_from_the_German_Transcatheter_Mitral_Valve_Interventions__TRAMI__Registry_ L2 - https://doi.org/10.1002/ccd.25493 DB - PRIME DP - Unbound Medicine ER -