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Healthcare databases in Europe for studying medicine use and safety during pregnancy.
Pharmacoepidemiol Drug Saf. 2014 Jun; 23(6):586-94.PD

Abstract

PURPOSE

The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy.

METHODS

A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed.

RESULTS

Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status.

CONCLUSION

This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest. © 2014 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons, Ltd.

Authors+Show Affiliations

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24664855

Citation

Charlton, Rachel A., et al. "Healthcare Databases in Europe for Studying Medicine Use and Safety During Pregnancy." Pharmacoepidemiology and Drug Safety, vol. 23, no. 6, 2014, pp. 586-94.
Charlton RA, Neville AJ, Jordan S, et al. Healthcare databases in Europe for studying medicine use and safety during pregnancy. Pharmacoepidemiol Drug Saf. 2014;23(6):586-94.
Charlton, R. A., Neville, A. J., Jordan, S., Pierini, A., Damase-Michel, C., Klungsøyr, K., Andersen, A. M., Hansen, A. V., Gini, R., Bos, J. H., Puccini, A., Hurault-Delarue, C., Brooks, C. J., de Jong-van den Berg, L. T., & de Vries, C. S. (2014). Healthcare databases in Europe for studying medicine use and safety during pregnancy. Pharmacoepidemiology and Drug Safety, 23(6), 586-94. https://doi.org/10.1002/pds.3613
Charlton RA, et al. Healthcare Databases in Europe for Studying Medicine Use and Safety During Pregnancy. Pharmacoepidemiol Drug Saf. 2014;23(6):586-94. PubMed PMID: 24664855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healthcare databases in Europe for studying medicine use and safety during pregnancy. AU - Charlton,Rachel A, AU - Neville,Amanda J, AU - Jordan,Sue, AU - Pierini,Anna, AU - Damase-Michel,Christine, AU - Klungsøyr,Kari, AU - Andersen,Anne-Marie Nybo, AU - Hansen,Anne Vinkel, AU - Gini,Rosa, AU - Bos,Jens H J, AU - Puccini,Aurora, AU - Hurault-Delarue,Caroline, AU - Brooks,Caroline J, AU - de Jong-van den Berg,Lolkje T W, AU - de Vries,Corinne S, Y1 - 2014/03/24/ PY - 2013/11/19/received PY - 2014/02/19/revised PY - 2014/02/20/accepted PY - 2014/3/26/entrez PY - 2014/3/26/pubmed PY - 2015/1/27/medline KW - automated data KW - electronic medical records KW - pharmacoepidemiology KW - pregnancy KW - teratogens SP - 586 EP - 94 JF - Pharmacoepidemiology and drug safety JO - Pharmacoepidemiol Drug Saf VL - 23 IS - 6 N2 - PURPOSE: The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy. METHODS: A sample of electronic healthcare databases that captured pregnancies and prescription data was selected on the basis of contacts within the EUROCAT network. For each participating database, a database inventory was completed. RESULTS: Eight databases were included, and the total population covered was 25 million. All databases recorded live births, seven captured stillbirths and five had full data available on spontaneous pregnancy losses and induced terminations. In six databases, data were usually available to determine the date of the woman's last menstrual period, whereas in the remainder, algorithms were needed to establish a best estimate for at least some pregnancies. In seven databases, it was possible to use data recorded in the databases to identify pregnancies where the offspring had a congenital anomaly. Information on confounding variables was more commonly available in databases capturing data recorded by primary-care practitioners. All databases captured maternal co-prescribing and a measure of socioeconomic status. CONCLUSION: This study suggests that within Europe, electronic healthcare databases may be valuable sources of data for evaluating medicine use and safety during pregnancy. The suitability of a particular database, however, will depend on the research question, the type of medicine to be evaluated, the prevalence of its use and any adverse outcomes of interest. © 2014 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons, Ltd. SN - 1099-1557 UR - https://www.unboundmedicine.com/medline/citation/24664855/Healthcare_databases_in_Europe_for_studying_medicine_use_and_safety_during_pregnancy_ L2 - https://doi.org/10.1002/pds.3613 DB - PRIME DP - Unbound Medicine ER -