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Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in Minnesota.
Br J Cancer 2014; 110(9):2348-53BJ

Abstract

BACKGROUND

Associations between medical conditions and pancreatic cancer risk are controversial and are thus evaluated in a study conducted during 1994-1998 in Minnesota.

METHODS

Cases (n=215) were ascertained from hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic. Controls (n=676) were randomly selected from the general population and frequency matched to cases by age and sex. The history of medical conditions was gathered with a questionnaire during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression.

RESULTS

After adjustment for confounders, subjects who had cholecystectomy or gallstones experienced a significantly higher risk of pancreatic cancer than those who did not (OR (95% CI): 2.11 (1.32-3.35) for cholecystectomy and 1.97 (1.23-3.12) for gallstones), whereas opposite results were observed for tonsillectomy (0.67 (0.48-0.94)). Increased risk associated with cholecystectomy was the greatest when it occurred ≤ 2 years before the cancer diagnosis (5.93 (2.36-15.7)) but remained statistically significant when that interval was ≥ 20 years (2.27 (1.16-4.32)).

CONCLUSIONS

Cholecystectomy, gallstones, and tonsillectomy were associated with an altered risk of pancreatic cancer. Our study suggests that cholecystectomy increased risk but reverse causality may partially account for high risk associated with recent cholecystectomy.

Authors+Show Affiliations

1] Department of Epidemiology, Indiana University, Richard M. Fairbanks School of Public Health at IUPUI, Indianapolis, IN 46202, USA [2] Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA.Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.Department of Biostatistics, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.1] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA [2] Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24667646

Citation

Zhang, J, et al. "Cholecystectomy, Gallstones, Tonsillectomy, and Pancreatic Cancer Risk: a Population-based Case-control Study in Minnesota." British Journal of Cancer, vol. 110, no. 9, 2014, pp. 2348-53.
Zhang J, Prizment AE, Dhakal IB, et al. Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in Minnesota. Br J Cancer. 2014;110(9):2348-53.
Zhang, J., Prizment, A. E., Dhakal, I. B., & Anderson, K. E. (2014). Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in Minnesota. British Journal of Cancer, 110(9), pp. 2348-53. doi:10.1038/bjc.2014.154.
Zhang J, et al. Cholecystectomy, Gallstones, Tonsillectomy, and Pancreatic Cancer Risk: a Population-based Case-control Study in Minnesota. Br J Cancer. 2014 Apr 29;110(9):2348-53. PubMed PMID: 24667646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholecystectomy, gallstones, tonsillectomy, and pancreatic cancer risk: a population-based case-control study in Minnesota. AU - Zhang,J, AU - Prizment,A E, AU - Dhakal,I B, AU - Anderson,K E, Y1 - 2014/03/25/ PY - 2013/11/08/received PY - 2014/02/27/revised PY - 2014/02/28/accepted PY - 2014/3/27/entrez PY - 2014/3/29/pubmed PY - 2014/7/7/medline SP - 2348 EP - 53 JF - British journal of cancer JO - Br. J. Cancer VL - 110 IS - 9 N2 - BACKGROUND: Associations between medical conditions and pancreatic cancer risk are controversial and are thus evaluated in a study conducted during 1994-1998 in Minnesota. METHODS: Cases (n=215) were ascertained from hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic. Controls (n=676) were randomly selected from the general population and frequency matched to cases by age and sex. The history of medical conditions was gathered with a questionnaire during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression. RESULTS: After adjustment for confounders, subjects who had cholecystectomy or gallstones experienced a significantly higher risk of pancreatic cancer than those who did not (OR (95% CI): 2.11 (1.32-3.35) for cholecystectomy and 1.97 (1.23-3.12) for gallstones), whereas opposite results were observed for tonsillectomy (0.67 (0.48-0.94)). Increased risk associated with cholecystectomy was the greatest when it occurred ≤ 2 years before the cancer diagnosis (5.93 (2.36-15.7)) but remained statistically significant when that interval was ≥ 20 years (2.27 (1.16-4.32)). CONCLUSIONS: Cholecystectomy, gallstones, and tonsillectomy were associated with an altered risk of pancreatic cancer. Our study suggests that cholecystectomy increased risk but reverse causality may partially account for high risk associated with recent cholecystectomy. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/24667646/Cholecystectomy_gallstones_tonsillectomy_and_pancreatic_cancer_risk:_a_population_based_case_control_study_in_Minnesota_ L2 - http://dx.doi.org/10.1038/bjc.2014.154 DB - PRIME DP - Unbound Medicine ER -