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Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis.
Mod Rheumatol. 2014 Nov; 24(6):926-30.MR

Abstract

OBJECTIVES

Reactive oxygen species (ROS) are considered to be involved in the pathobiology of rheumatoid arthritis (RA); however, their association with disease activity has not been elucidated. In this study, we measured reactive oxygen metabolites (ROM) in patients with RA using a new Free Radical Analytical System and determined clinical parameters associated with ROM.

METHODS

One hundred and fifty-two patients with RA and 80 patients with diabetes mellitus (DM) were included in this observational study. To measure ROM, the d-ROM test was performed on blood samples drawn from all subjects. The correlation between ROM and biomarkers, disease activity, doses of methotrexate (MTX), and prednisolone (PSL) were investigated.

RESULTS

There were significant, positive correlations between ROM and CRP, matrix metalloproteinase 3 (MMP3), Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease Activity Index (CDAI), and the Simplified Disease Activity Index (SDAI). Multiple regression analysis revealed that CRP and DAS28-ESR were correlated with ROM.

CONCLUSIONS

The serum level of ROM was associated with CRP and DAS28-ESR, suggesting that ROM, in conjunction with CRP and MMP3, may be able to be used as a new biological disease marker to evaluate the disease activity of RA.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Nakajima A
Department of Orthopedics, Toho University Sakura Medical Center , Sakura, Chiba , Japan.
Aoki Y
No affiliation info available
Shibata Y
No affiliation info available
Sonobe M
No affiliation info available
Terajima F
No affiliation info available
Takahashi H
No affiliation info available
Saito M
No affiliation info available
Taniguchi S
No affiliation info available
Yamada M
No affiliation info available
Nakagawa K
No affiliation info available

MeSH

AdultAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidBiomarkersDiabetes MellitusFemaleHumansMaleMiddle AgedOxidative StressReactive Oxygen SpeciesSeverity of Illness IndexYoung Adult

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

24670128

Citation

Nakajima, Arata, et al. "Identification of Clinical Parameters Associated With Serum Oxidative Stress in Patients With Rheumatoid Arthritis." Modern Rheumatology, vol. 24, no. 6, 2014, pp. 926-30.
Nakajima A, Aoki Y, Shibata Y, et al. Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis. Mod Rheumatol. 2014;24(6):926-30.
Nakajima, A., Aoki, Y., Shibata, Y., Sonobe, M., Terajima, F., Takahashi, H., Saito, M., Taniguchi, S., Yamada, M., & Nakagawa, K. (2014). Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis. Modern Rheumatology, 24(6), 926-30. https://doi.org/10.3109/14397595.2014.891495
Nakajima A, et al. Identification of Clinical Parameters Associated With Serum Oxidative Stress in Patients With Rheumatoid Arthritis. Mod Rheumatol. 2014;24(6):926-30. PubMed PMID: 24670128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis. AU - Nakajima,Arata, AU - Aoki,Yasuchika, AU - Shibata,Yoshifumi, AU - Sonobe,Masato, AU - Terajima,Fumiaki, AU - Takahashi,Hiroshi, AU - Saito,Masahiko, AU - Taniguchi,Shinji, AU - Yamada,Manabu, AU - Nakagawa,Koichi, Y1 - 2014/03/26/ PY - 2014/3/28/entrez PY - 2014/3/29/pubmed PY - 2015/6/26/medline KW - Disease activity KW - Oxidative stress KW - Reactive oxygen metabolites KW - Rheumatoid arthritis SP - 926 EP - 30 JF - Modern rheumatology JO - Mod Rheumatol VL - 24 IS - 6 N2 - OBJECTIVES: Reactive oxygen species (ROS) are considered to be involved in the pathobiology of rheumatoid arthritis (RA); however, their association with disease activity has not been elucidated. In this study, we measured reactive oxygen metabolites (ROM) in patients with RA using a new Free Radical Analytical System and determined clinical parameters associated with ROM. METHODS: One hundred and fifty-two patients with RA and 80 patients with diabetes mellitus (DM) were included in this observational study. To measure ROM, the d-ROM test was performed on blood samples drawn from all subjects. The correlation between ROM and biomarkers, disease activity, doses of methotrexate (MTX), and prednisolone (PSL) were investigated. RESULTS: There were significant, positive correlations between ROM and CRP, matrix metalloproteinase 3 (MMP3), Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease Activity Index (CDAI), and the Simplified Disease Activity Index (SDAI). Multiple regression analysis revealed that CRP and DAS28-ESR were correlated with ROM. CONCLUSIONS: The serum level of ROM was associated with CRP and DAS28-ESR, suggesting that ROM, in conjunction with CRP and MMP3, may be able to be used as a new biological disease marker to evaluate the disease activity of RA. SN - 1439-7609 UR - https://www.unboundmedicine.com/medline/citation/24670128/Identification_of_clinical_parameters_associated_with_serum_oxidative_stress_in_patients_with_rheumatoid_arthritis_ DB - PRIME DP - Unbound Medicine ER -