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Neuropsychological correlates of hippocampal atrophy in memory testing in nondemented older adults.
J Alzheimers Dis 2014; 42 Suppl 3:S81-90JA

Abstract

BACKGROUND AND OBJECTIVE

Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. Among tests used to evaluate memory, verbal memory tests with controlled encoding and cued recall are believed to be specific for hippocampal impairment. The objective of this study was to assess the relation between left and right hippocampal volumes and several frequently used memory tests.

METHODS

Fifty six nondemented older adults (30 with amnestic mild cognitive impairment and 26 cognitively healthy older adults) underwent neuropsychological testing including: (1) The Enhanced Cued Recall test (ECR), a memory test with controlled encoding and recall; (2) the Auditory Verbal Learning Test (AVLT), a verbal memory test without controlled encoding and with delayed recall; and (3) The Rey-Osterrieth Complex Figure test (ROCF), a visuospatial memory test-recall condition. 1.5T brain MRI scans were used to measure estimated total intracranial volume (eTIV) along with hippocampal right and left volumes, which were measured with quantitative volumetry using FreeSurfer package (version 4.4.0). Spearman partial correlation controlled for age was used to correct for non-normal score distribution and effect of age.

RESULTS

We found moderate correlations of hippocampal volumes with AVLT 1-5 scores, AVLT delayed recall, ECR free and total recall, and ROCF reproduction. Total recall in ECR using cued recall was not superior to any of the free recall tests. No correlation in any memory test was achieved with eTIV.

CONCLUSION

Verbal memory tests, either with controlled encoding and cued delayed recall (ECR), or without it (AVLT), as well as nonverbal memory test with delayed recall (ROCF), equally reflect hippocampal atrophy in nondemented older adults.

Authors+Show Affiliations

International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic School of Aging Studies, University of South Florida, Tampa, USA.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine and General University Hospital in Prague, Charles University in Prague, Prague, Czech Republic.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic Memory Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24670399

Citation

Vyhnalek, Martin, et al. "Neuropsychological Correlates of Hippocampal Atrophy in Memory Testing in Nondemented Older Adults." Journal of Alzheimer's Disease : JAD, vol. 42 Suppl 3, 2014, pp. S81-90.
Vyhnalek M, Nikolai T, Andel R, et al. Neuropsychological correlates of hippocampal atrophy in memory testing in nondemented older adults. J Alzheimers Dis. 2014;42 Suppl 3:S81-90.
Vyhnalek, M., Nikolai, T., Andel, R., Nedelska, Z., Rubínová, E., Marková, H., ... Hort, J. (2014). Neuropsychological correlates of hippocampal atrophy in memory testing in nondemented older adults. Journal of Alzheimer's Disease : JAD, 42 Suppl 3, pp. S81-90. doi:10.3233/JAD-132642.
Vyhnalek M, et al. Neuropsychological Correlates of Hippocampal Atrophy in Memory Testing in Nondemented Older Adults. J Alzheimers Dis. 2014;42 Suppl 3:S81-90. PubMed PMID: 24670399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychological correlates of hippocampal atrophy in memory testing in nondemented older adults. AU - Vyhnalek,Martin, AU - Nikolai,Tomas, AU - Andel,Ross, AU - Nedelska,Zuzana, AU - Rubínová,Eva, AU - Marková,Hana, AU - Laczó,Jan, AU - Bezdicek,Ondrej, AU - Sheardova,Katerina, AU - Hort,Jakub, PY - 2014/3/28/entrez PY - 2014/3/29/pubmed PY - 2015/6/30/medline KW - Amnestic mild cognitive impairment KW - MRI KW - episodic memory KW - hippocampus SP - S81 EP - 90 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 42 Suppl 3 N2 - BACKGROUND AND OBJECTIVE: Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. Among tests used to evaluate memory, verbal memory tests with controlled encoding and cued recall are believed to be specific for hippocampal impairment. The objective of this study was to assess the relation between left and right hippocampal volumes and several frequently used memory tests. METHODS: Fifty six nondemented older adults (30 with amnestic mild cognitive impairment and 26 cognitively healthy older adults) underwent neuropsychological testing including: (1) The Enhanced Cued Recall test (ECR), a memory test with controlled encoding and recall; (2) the Auditory Verbal Learning Test (AVLT), a verbal memory test without controlled encoding and with delayed recall; and (3) The Rey-Osterrieth Complex Figure test (ROCF), a visuospatial memory test-recall condition. 1.5T brain MRI scans were used to measure estimated total intracranial volume (eTIV) along with hippocampal right and left volumes, which were measured with quantitative volumetry using FreeSurfer package (version 4.4.0). Spearman partial correlation controlled for age was used to correct for non-normal score distribution and effect of age. RESULTS: We found moderate correlations of hippocampal volumes with AVLT 1-5 scores, AVLT delayed recall, ECR free and total recall, and ROCF reproduction. Total recall in ECR using cued recall was not superior to any of the free recall tests. No correlation in any memory test was achieved with eTIV. CONCLUSION: Verbal memory tests, either with controlled encoding and cued delayed recall (ECR), or without it (AVLT), as well as nonverbal memory test with delayed recall (ROCF), equally reflect hippocampal atrophy in nondemented older adults. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/24670399/Neuropsychological_correlates_of_hippocampal_atrophy_in_memory_testing_in_nondemented_older_adults_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-132642 DB - PRIME DP - Unbound Medicine ER -