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Susceptible genes regulate the adverse effects of TiO2-NPs at predicted environmental relevant concentrations on nematode Caenorhabditis elegans.
Nanomedicine. 2014 Aug; 10(6):1263-71.N

Abstract

Contributions from mutations of susceptible genes to TiO2-NPs toxicity at environmental relevant concentrations (ERCs) and the underlying mechanism are largely unclear. After prolonged exposure, among the examined 19 mutants associated with oxidative stress or stress response, we show that sod-2, sod-3, mtl-2, and hsp-16.48 were susceptible genes for TiO2-NPs toxicity on reproduction and locomotion behavior, sod-2, sod-3, and mtl-2 were susceptible genes for TiO2-NPs toxicity on survival and intestinal development, and mtl-2 was susceptible gene for TiO2-NPs toxicity on development. Mutations of these susceptible genes, together with sensitive endpoints, could be used to evaluate TiO2-NPs toxicity at the concentration of 0.0001μg/L. Our results imply the usefulness of identified susceptible genes in assessing the potential nanotoxicity of engineered nanomaterial (ENM) at ERCs. One important mechanism to explain property of identified susceptible genes for TiO2-NPs toxicity was that mutations of these susceptible genes enhanced the uptake of TiO2-NPs into body of nematodes.

FROM THE CLINICAL EDITOR

This team of authors identified susceptibility genes influencing the uptake and consequential toxicity of TiO2 nanoparticles in a nematode, highlighting the general importance of investigating genetic influence on nanoparticle delivery.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wu Q
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School of Southeast University, Nanjing, China.
Zhao Y
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School of Southeast University, Nanjing, China.
Li Y
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School of Southeast University, Nanjing, China.
Wang D
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School of Southeast University, Nanjing, China. Electronic address: dayongw@seu.edu.cn.

MeSH

AnimalsCaenorhabditis elegansGenes, HelminthLocomotionMutagensNanoparticlesOxidative StressReactive Oxygen SpeciesReproductionTitanium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24674972

Citation

Wu, Qiuli, et al. "Susceptible Genes Regulate the Adverse Effects of TiO2-NPs at Predicted Environmental Relevant Concentrations On Nematode Caenorhabditis Elegans." Nanomedicine : Nanotechnology, Biology, and Medicine, vol. 10, no. 6, 2014, pp. 1263-71.
Wu Q, Zhao Y, Li Y, et al. Susceptible genes regulate the adverse effects of TiO2-NPs at predicted environmental relevant concentrations on nematode Caenorhabditis elegans. Nanomedicine. 2014;10(6):1263-71.
Wu, Q., Zhao, Y., Li, Y., & Wang, D. (2014). Susceptible genes regulate the adverse effects of TiO2-NPs at predicted environmental relevant concentrations on nematode Caenorhabditis elegans. Nanomedicine : Nanotechnology, Biology, and Medicine, 10(6), 1263-71. https://doi.org/10.1016/j.nano.2014.03.010
Wu Q, et al. Susceptible Genes Regulate the Adverse Effects of TiO2-NPs at Predicted Environmental Relevant Concentrations On Nematode Caenorhabditis Elegans. Nanomedicine. 2014;10(6):1263-71. PubMed PMID: 24674972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptible genes regulate the adverse effects of TiO2-NPs at predicted environmental relevant concentrations on nematode Caenorhabditis elegans. AU - Wu,Qiuli, AU - Zhao,Yunli, AU - Li,Yiping, AU - Wang,Dayong, Y1 - 2014/03/25/ PY - 2013/12/23/received PY - 2014/03/07/revised PY - 2014/03/12/accepted PY - 2014/3/29/entrez PY - 2014/3/29/pubmed PY - 2015/3/31/medline KW - Caenorhabditis elegans KW - Predicted environmental relevant concentration KW - Susceptible gene KW - TiO(2)-NPs KW - Uptake SP - 1263 EP - 71 JF - Nanomedicine : nanotechnology, biology, and medicine JO - Nanomedicine VL - 10 IS - 6 N2 - : Contributions from mutations of susceptible genes to TiO2-NPs toxicity at environmental relevant concentrations (ERCs) and the underlying mechanism are largely unclear. After prolonged exposure, among the examined 19 mutants associated with oxidative stress or stress response, we show that sod-2, sod-3, mtl-2, and hsp-16.48 were susceptible genes for TiO2-NPs toxicity on reproduction and locomotion behavior, sod-2, sod-3, and mtl-2 were susceptible genes for TiO2-NPs toxicity on survival and intestinal development, and mtl-2 was susceptible gene for TiO2-NPs toxicity on development. Mutations of these susceptible genes, together with sensitive endpoints, could be used to evaluate TiO2-NPs toxicity at the concentration of 0.0001μg/L. Our results imply the usefulness of identified susceptible genes in assessing the potential nanotoxicity of engineered nanomaterial (ENM) at ERCs. One important mechanism to explain property of identified susceptible genes for TiO2-NPs toxicity was that mutations of these susceptible genes enhanced the uptake of TiO2-NPs into body of nematodes. FROM THE CLINICAL EDITOR: This team of authors identified susceptibility genes influencing the uptake and consequential toxicity of TiO2 nanoparticles in a nematode, highlighting the general importance of investigating genetic influence on nanoparticle delivery. SN - 1549-9642 UR - https://www.unboundmedicine.com/medline/citation/24674972/Susceptible_genes_regulate_the_adverse_effects_of_TiO2_NPs_at_predicted_environmental_relevant_concentrations_on_nematode_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -
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