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Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction.
Mol Med Rep. 2014 Jun; 9(6):2459-66.MM

Abstract

Silent brain infarction (SBI) is an asymptomatic cerebrovascular disorder. The aim of the present study was to investigate the association between adrenoceptor-α2 (ADRA2) gene polymorphisms and SBI. A total of 361 patients with SBI and 467 healthy control subjects were examined. The polymerase chain reaction was performed to genotype the ADRA2A 1780G>A, ADRA2B 301-303 insertion/deletion (I/D) and ADRA2C 322-325I/D polymorphisms. The frequency of the ADRA2C 322-325I/D polymorphism was significantly different between patients with SBI and control subjects. When interaction analyses were performed for vascular risk factors, the ADRA2C 322-325ID genotype increased the risk for SBI in the presence of hypertension and elevated plasma homocysteine levels. The ADRA2C 322-325ID genotype and plasma homocysteine levels showed a significant synergistic effect for SBI. In addition, the ADRA2A 1780AA genotype was associated with elevated plasma homocysteine levels. Although further analysis of the association between ADRA2 polymorphisms and clinical risk factors of SBI is required, the present study of a limited set of SBI risk factors with ADRA2 polymorphisms provides the first evidence of the involvement of ADRA2 gene family members in the development of SBI. Further studies using larger and more heterogeneous populations are required to validate the association of ADRA2 polymorphisms with SBI.

Authors+Show Affiliations

Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea.Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea.Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do 463-712, Republic of Korea.Department of Neurology, Chonbuk National University Hospital and Medical School, Jeonju 561-712, Republic of Korea.Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.Department of Medicine, College of Medicine, Chung-Ang University Seoul 156-756, Republic of Korea.Department of Internal Medicine, CHA Gangnam Medical Center, CHA University, Seoul 135-913, Republic of Korea.Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do 463-712, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24676565

Citation

Kim, Jung O., et al. "Association Between Common Genetic Variants of α2A-, α2B- and α2C-adrenoceptors and the Risk of Silent Brain Infarction." Molecular Medicine Reports, vol. 9, no. 6, 2014, pp. 2459-66.
Kim JO, Jeon YJ, Kim OJ, et al. Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction. Mol Med Rep. 2014;9(6):2459-66.
Kim, J. O., Jeon, Y. J., Kim, O. J., Oh, S. H., Kim, H. S., Shin, B. S., Oh, D., Kim, E. J., Cho, Y. K., & Kim, N. K. (2014). Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction. Molecular Medicine Reports, 9(6), 2459-66. https://doi.org/10.3892/mmr.2014.2072
Kim JO, et al. Association Between Common Genetic Variants of α2A-, α2B- and α2C-adrenoceptors and the Risk of Silent Brain Infarction. Mol Med Rep. 2014;9(6):2459-66. PubMed PMID: 24676565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction. AU - Kim,Jung O, AU - Jeon,Young Joo, AU - Kim,Ok Joon, AU - Oh,Seung Hun, AU - Kim,Hyun Sook, AU - Shin,Byoung Soo, AU - Oh,Doyeun, AU - Kim,Eo Jin, AU - Cho,Yun Kyung, AU - Kim,Nam Keun, Y1 - 2014/03/27/ PY - 2013/06/27/received PY - 2014/03/04/accepted PY - 2014/3/29/entrez PY - 2014/3/29/pubmed PY - 2015/1/6/medline SP - 2459 EP - 66 JF - Molecular medicine reports JO - Mol Med Rep VL - 9 IS - 6 N2 - Silent brain infarction (SBI) is an asymptomatic cerebrovascular disorder. The aim of the present study was to investigate the association between adrenoceptor-α2 (ADRA2) gene polymorphisms and SBI. A total of 361 patients with SBI and 467 healthy control subjects were examined. The polymerase chain reaction was performed to genotype the ADRA2A 1780G>A, ADRA2B 301-303 insertion/deletion (I/D) and ADRA2C 322-325I/D polymorphisms. The frequency of the ADRA2C 322-325I/D polymorphism was significantly different between patients with SBI and control subjects. When interaction analyses were performed for vascular risk factors, the ADRA2C 322-325ID genotype increased the risk for SBI in the presence of hypertension and elevated plasma homocysteine levels. The ADRA2C 322-325ID genotype and plasma homocysteine levels showed a significant synergistic effect for SBI. In addition, the ADRA2A 1780AA genotype was associated with elevated plasma homocysteine levels. Although further analysis of the association between ADRA2 polymorphisms and clinical risk factors of SBI is required, the present study of a limited set of SBI risk factors with ADRA2 polymorphisms provides the first evidence of the involvement of ADRA2 gene family members in the development of SBI. Further studies using larger and more heterogeneous populations are required to validate the association of ADRA2 polymorphisms with SBI. SN - 1791-3004 UR - https://www.unboundmedicine.com/medline/citation/24676565/Association_between_common_genetic_variants_of_α2A__α2B__and_α2C_adrenoceptors_and_the_risk_of_silent_brain_infarction_ L2 - http://www.spandidos-publications.com/mmr/9/6/2459 DB - PRIME DP - Unbound Medicine ER -