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Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population.
BMC Res Notes 2014; 7:194BR

Abstract

BACKGROUND

Polymorphisms within the apolipoprotein-E (APOE), Methylenetetrahydrofolate reductase (MTHFR) and Angiotensin I-converting enzyme (ACE) genes has been associated with cardiovascular and cerebrovascular disorders, Alzheimer's disease and other complex diseases in various populations. The aim of the study was to analyze the allelic and genotypic frequencies of APOE, MTHFR C677T and ACE I/D gene polymorphisms in the Zambian population.

RESULTS

The allele frequencies of APOE polymorphism in the Zambian populations were 13.8%, 59.5% and 26.7% for the ε2, ε3 and ε4 alleles respectively. MTHFR C677T and ACE I/D allele frequencies were 8.6% and 13.8% for the T and D minor alleles respectively. The ε2ε2 genotype and TT genotype were absent in the Zambian population. The genetic distances between Zambian and other African and non-African major populations revealed an independent variability of these polymorphisms.

CONCLUSION

We found that the APOE ε3 allele and the I allele of the ACE were significantly high in our study population while there were low frequencies observed for the MTHFR 677 T and ACE D alleles. Our analysis of the APOE, MTHFR and ACE polymorphisms may provide valuable insight into the understanding of the disease risk in the Zambian population.

Authors+Show Affiliations

Department of Internal Medicine, University of Zambia, P,O,Box 51237, Lusaka, Zambia. masharip.atadzhanov@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24679048

Citation

Atadzhanov, Masharip, et al. "Frequency of APOE, MTHFR and ACE Polymorphisms in the Zambian Population." BMC Research Notes, vol. 7, 2014, p. 194.
Atadzhanov M, Mwaba MH, Mukomena PN, et al. Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population. BMC Res Notes. 2014;7:194.
Atadzhanov, M., Mwaba, M. H., Mukomena, P. N., Lakhi, S., Mwaba, P., Rayaprolu, S., ... Ross, O. A. (2014). Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population. BMC Research Notes, 7, p. 194. doi:10.1186/1756-0500-7-194.
Atadzhanov M, et al. Frequency of APOE, MTHFR and ACE Polymorphisms in the Zambian Population. BMC Res Notes. 2014 Mar 28;7:194. PubMed PMID: 24679048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population. AU - Atadzhanov,Masharip, AU - Mwaba,Mwila H, AU - Mukomena,Patrice N, AU - Lakhi,Shabir, AU - Mwaba,Peter, AU - Rayaprolu,Sruti, AU - Meschia,James F, AU - Ross,Owen A, Y1 - 2014/03/28/ PY - 2013/01/22/received PY - 2014/03/21/accepted PY - 2014/4/1/entrez PY - 2014/4/1/pubmed PY - 2014/12/15/medline SP - 194 EP - 194 JF - BMC research notes JO - BMC Res Notes VL - 7 N2 - BACKGROUND: Polymorphisms within the apolipoprotein-E (APOE), Methylenetetrahydrofolate reductase (MTHFR) and Angiotensin I-converting enzyme (ACE) genes has been associated with cardiovascular and cerebrovascular disorders, Alzheimer's disease and other complex diseases in various populations. The aim of the study was to analyze the allelic and genotypic frequencies of APOE, MTHFR C677T and ACE I/D gene polymorphisms in the Zambian population. RESULTS: The allele frequencies of APOE polymorphism in the Zambian populations were 13.8%, 59.5% and 26.7% for the ε2, ε3 and ε4 alleles respectively. MTHFR C677T and ACE I/D allele frequencies were 8.6% and 13.8% for the T and D minor alleles respectively. The ε2ε2 genotype and TT genotype were absent in the Zambian population. The genetic distances between Zambian and other African and non-African major populations revealed an independent variability of these polymorphisms. CONCLUSION: We found that the APOE ε3 allele and the I allele of the ACE were significantly high in our study population while there were low frequencies observed for the MTHFR 677 T and ACE D alleles. Our analysis of the APOE, MTHFR and ACE polymorphisms may provide valuable insight into the understanding of the disease risk in the Zambian population. SN - 1756-0500 UR - https://www.unboundmedicine.com/medline/citation/24679048/Frequency_of_APOE_MTHFR_and_ACE_polymorphisms_in_the_Zambian_population_ L2 - https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-7-194 DB - PRIME DP - Unbound Medicine ER -