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Pathophysiology of portal hypertension.
Clin Liver Dis. 2014 May; 18(2):281-91.CL

Abstract

Portal hypertension is a major complication of liver disease that results from a variety of pathologic conditions that increase the resistance to the portal blood flow into the liver. As portal hypertension develops, the formation of collateral vessels and arterial vasodilation progresses, which results in increased blood flow to the portal circulation. Hyperdynamic circulatory syndrome develops, leading to esophageal varices or ascites. This article summarizes the factors that increase (1) intrahepatic vascular resistance and (2) the blood flow in the splanchnic and systemic circulations in liver cirrhosis. In addition, the future directions of basic/clinical research in portal hypertension are discussed.

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Authors+Show Affiliations

Iwakiri Y
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 1080 LMP, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: yasuko.iwakiri@yale.edu.

MeSH

Collateral CirculationEndothelial CellsHepatic Stellate CellsHumansHypertension, PortalLiver CirculationLiver CirrhosisNeovascularization, PathologicSplanchnic CirculationVascular ResistanceVasoconstrictionVasodilation

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

24679494

Citation

Iwakiri, Yasuko. "Pathophysiology of Portal Hypertension." Clinics in Liver Disease, vol. 18, no. 2, 2014, pp. 281-91.
Iwakiri Y. Pathophysiology of portal hypertension. Clin Liver Dis. 2014;18(2):281-91.
Iwakiri, Y. (2014). Pathophysiology of portal hypertension. Clinics in Liver Disease, 18(2), 281-91. https://doi.org/10.1016/j.cld.2013.12.001
Iwakiri Y. Pathophysiology of Portal Hypertension. Clin Liver Dis. 2014;18(2):281-91. PubMed PMID: 24679494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathophysiology of portal hypertension. A1 - Iwakiri,Yasuko, Y1 - 2014/02/25/ PY - 2014/4/1/entrez PY - 2014/4/1/pubmed PY - 2015/2/20/medline KW - Cirrhosis KW - Fibrosis KW - Hyperdynamic circulation KW - Lymphatic system KW - Nitric oxide KW - Splenomegaly SP - 281 EP - 91 JF - Clinics in liver disease JO - Clin Liver Dis VL - 18 IS - 2 N2 - Portal hypertension is a major complication of liver disease that results from a variety of pathologic conditions that increase the resistance to the portal blood flow into the liver. As portal hypertension develops, the formation of collateral vessels and arterial vasodilation progresses, which results in increased blood flow to the portal circulation. Hyperdynamic circulatory syndrome develops, leading to esophageal varices or ascites. This article summarizes the factors that increase (1) intrahepatic vascular resistance and (2) the blood flow in the splanchnic and systemic circulations in liver cirrhosis. In addition, the future directions of basic/clinical research in portal hypertension are discussed. SN - 1557-8224 UR - https://www.unboundmedicine.com/medline/citation/24679494/Pathophysiology_of_portal_hypertension_ DB - PRIME DP - Unbound Medicine ER -