Tags

Type your tag names separated by a space and hit enter

Determinants of the quality of life in Parkinson's disease: results of a cohort study from Southwest China.
J Neurol Sci. 2014 May 15; 340(1-2):144-9.JN

Abstract

BACKGROUND

The determinants of the quality of life (QoL) of patients with Parkinson's disease (PD) in Chinese population remain largely unknown.

METHODS

A total of 649 PD patients from Southwest China participated in this cross-sectional study. Non-motor Symptoms Scale (NMSS) was used to evaluate the non-motor symptoms (NMS), whereas PD Quality of Life Questionnaire (PDQ-39) was used to assess the QoL of the PD patients. Multiple stepwise regression analysis was conducted to identify the determinants of the QoL.

RESULTS

NMS, H-Y stage, female, disease duration, UPDRS III score, single/divorced/widowed, and motor complications accounted for 66.3% of the variables in the multiple regression analysis and were the negative determinants of the QoL. Among these variables, NMS and H-Y stage accounted for 46.7% and 14.5%, respectively. NMS were closely associated with each domain of PDQ-39. Female sex especially predicted poor emotional well-being and bodily discomfort, whereas single/divorced/widowed especially predicted poor stigma and social support of PD patients. Comorbidity, motor complications and rural living predicted poor mobility, activities of daily living and emotional well-being, respectively.

CONCLUSION

Both demographic and disease-specific factors influence the QoL in PD patients. NMS are the strongest independent negative determinant of the overall QoL and closely associated with each domain of PDQ-39. The treatment of NMS may help to improve the QoL of PD patients.

Authors+Show Affiliations

Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address: hfshang2002@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24679837

Citation

Wu, Ying, et al. "Determinants of the Quality of Life in Parkinson's Disease: Results of a Cohort Study From Southwest China." Journal of the Neurological Sciences, vol. 340, no. 1-2, 2014, pp. 144-9.
Wu Y, Guo XY, Wei QQ, et al. Determinants of the quality of life in Parkinson's disease: results of a cohort study from Southwest China. J Neurol Sci. 2014;340(1-2):144-9.
Wu, Y., Guo, X. Y., Wei, Q. Q., Song, W., Chen, K., Cao, B., Ou, R. W., Zhao, B., & Shang, H. F. (2014). Determinants of the quality of life in Parkinson's disease: results of a cohort study from Southwest China. Journal of the Neurological Sciences, 340(1-2), 144-9. https://doi.org/10.1016/j.jns.2014.03.014
Wu Y, et al. Determinants of the Quality of Life in Parkinson's Disease: Results of a Cohort Study From Southwest China. J Neurol Sci. 2014 May 15;340(1-2):144-9. PubMed PMID: 24679837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determinants of the quality of life in Parkinson's disease: results of a cohort study from Southwest China. AU - Wu,Ying, AU - Guo,Xiao Yan, AU - Wei,Qian Qian, AU - Song,Wei, AU - Chen,Ke, AU - Cao,Bei, AU - Ou,Ru Wei, AU - Zhao,Bi, AU - Shang,Hui Fang, Y1 - 2014/03/14/ PY - 2013/12/03/received PY - 2014/02/08/revised PY - 2014/03/06/accepted PY - 2014/4/1/entrez PY - 2014/4/1/pubmed PY - 2014/12/23/medline KW - Determinants KW - Motor severity KW - Non-motor symptoms (NMS) KW - PDQ-39 KW - Parkinson disease KW - Quality of life (QoL) SP - 144 EP - 9 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 340 IS - 1-2 N2 - BACKGROUND: The determinants of the quality of life (QoL) of patients with Parkinson's disease (PD) in Chinese population remain largely unknown. METHODS: A total of 649 PD patients from Southwest China participated in this cross-sectional study. Non-motor Symptoms Scale (NMSS) was used to evaluate the non-motor symptoms (NMS), whereas PD Quality of Life Questionnaire (PDQ-39) was used to assess the QoL of the PD patients. Multiple stepwise regression analysis was conducted to identify the determinants of the QoL. RESULTS: NMS, H-Y stage, female, disease duration, UPDRS III score, single/divorced/widowed, and motor complications accounted for 66.3% of the variables in the multiple regression analysis and were the negative determinants of the QoL. Among these variables, NMS and H-Y stage accounted for 46.7% and 14.5%, respectively. NMS were closely associated with each domain of PDQ-39. Female sex especially predicted poor emotional well-being and bodily discomfort, whereas single/divorced/widowed especially predicted poor stigma and social support of PD patients. Comorbidity, motor complications and rural living predicted poor mobility, activities of daily living and emotional well-being, respectively. CONCLUSION: Both demographic and disease-specific factors influence the QoL in PD patients. NMS are the strongest independent negative determinant of the overall QoL and closely associated with each domain of PDQ-39. The treatment of NMS may help to improve the QoL of PD patients. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/24679837/Determinants_of_the_quality_of_life_in_Parkinson's_disease:_results_of_a_cohort_study_from_Southwest_China_ DB - PRIME DP - Unbound Medicine ER -