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Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial.
Phytomedicine. 2014 May 15; 21(6):901-5.P

Abstract

In recent years, wide utilization of herbal drugs has encouraged scientists to determine their impressive effects on health. Since Nigella sativa L. seed (N. sativa) has many uses including infertility in traditional medicine, the effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men with abnormal semen quality are of interest. This study was conducted on Iranian infertile men with inclusion criteria of abnormal sperm morphology less than 30% or sperm counts below 20×10(6)/ml or type A and B motility less than 25% and 50% respectively. The patients in N. sativa oil group (n=34) received 2.5mlN. sativa oil and placebo group (n=34) received 2.5ml liquid paraffin two times a day orally for 2 months. At baseline and after 2 months, the sperm count, motility and morphology and semen volume, pH and round cells as primary outcomes were determined in both groups. Results showed that sperm count, motility and morphology and semen volume, pH and round cells were improved significantly in N. sativa oil treated group compared with placebo group after 2 months. It is concluded that daily intake of 5ml N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects.

Authors+Show Affiliations

Department of Biology, Payamenoor University, Tehran, Iran.Department of Biology, Payamenoor University, Tehran, Iran.Department of Obstetrics and Gynecology, Mahdieh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Alborz, Karaj, Iran.Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Alborz, Karaj, Iran. Electronic address: huseini_fallah@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24680621

Citation

Kolahdooz, M, et al. "Effects of Nigella Sativa L. Seed Oil On Abnormal Semen Quality in Infertile Men: a Randomized, Double-blind, Placebo-controlled Clinical Trial." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 21, no. 6, 2014, pp. 901-5.
Kolahdooz M, Nasri S, Modarres SZ, et al. Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2014;21(6):901-5.
Kolahdooz, M., Nasri, S., Modarres, S. Z., Kianbakht, S., & Huseini, H. F. (2014). Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 21(6), 901-5. https://doi.org/10.1016/j.phymed.2014.02.006
Kolahdooz M, et al. Effects of Nigella Sativa L. Seed Oil On Abnormal Semen Quality in Infertile Men: a Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytomedicine. 2014 May 15;21(6):901-5. PubMed PMID: 24680621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. AU - Kolahdooz,M, AU - Nasri,S, AU - Modarres,S Zadeh, AU - Kianbakht,S, AU - Huseini,H Fallah, Y1 - 2014/03/25/ PY - 2013/08/27/received PY - 2013/12/01/revised PY - 2014/02/22/accepted PY - 2014/4/1/entrez PY - 2014/4/1/pubmed PY - 2015/1/3/medline KW - Abnormal semen quality KW - Male infertility KW - Nigella sativa seed oil KW - Traditional medicine SP - 901 EP - 5 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 21 IS - 6 N2 - In recent years, wide utilization of herbal drugs has encouraged scientists to determine their impressive effects on health. Since Nigella sativa L. seed (N. sativa) has many uses including infertility in traditional medicine, the effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men with abnormal semen quality are of interest. This study was conducted on Iranian infertile men with inclusion criteria of abnormal sperm morphology less than 30% or sperm counts below 20×10(6)/ml or type A and B motility less than 25% and 50% respectively. The patients in N. sativa oil group (n=34) received 2.5mlN. sativa oil and placebo group (n=34) received 2.5ml liquid paraffin two times a day orally for 2 months. At baseline and after 2 months, the sperm count, motility and morphology and semen volume, pH and round cells as primary outcomes were determined in both groups. Results showed that sperm count, motility and morphology and semen volume, pH and round cells were improved significantly in N. sativa oil treated group compared with placebo group after 2 months. It is concluded that daily intake of 5ml N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/24680621/Effects_of_Nigella_sativa_L__seed_oil_on_abnormal_semen_quality_in_infertile_men:_a_randomized_double_blind_placebo_controlled_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(14)00108-1 DB - PRIME DP - Unbound Medicine ER -