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Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying.
Int J Pharm. 2014 Jun 05; 467(1-2):27-33.IJ

Abstract

Piroxicam (PRX) is a non-steroidal anti-inflammatory drug characterized by a poor water solubility and consequently by a low oral bioavailability. In this work, different nanocrystal orally disintegrating tablets (ODT) were prepared to enhance piroxicam dissolution rate and saturation solubility. PRX nanocrystals were prepared by means of high pressure homogenization technique using poloxamer 188 as stabilizer. Three different ODTs were prepared with the same nanosuspension using different excipients in order to study their effect on the PRX dissolution properties. PRX nanocrystal size and zeta potential were determined by photon correlation spectroscopy. Additional characterization of PRX nanocrystal ODT was carried out by infrared spectroscopy, X-ray powder diffractometry, differential scanning calorimetry. Dissolution study was performed in distilled water (pH 5.5) and compared with PRX coarse suspension ODT, PRX/poloxamer 188 physical mixture, bulk PRX samples and a PRX commercial ODT. All PRX nanocrystal ODT formulations showed a higher drug dissolution rate than coarse PRX ODT. PRX nanocrystal ODT prepared using gelatin or croscarmellose as excipient showed a higher PRX dissolution rate compared with the commercial formulation and ODT prepared using xanthan gum. Overall results confirmed that improved PRX dissolution rate is due to the increased surface-to-volume ratio due to the nanosized drug particle but also revealed the important role of different excipients used.

Authors+Show Affiliations

Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, CNBS, University of Cagliari, Cagliari 09124, Italy.Dipartimento di Scienze Farmaceutiche-Sezione di Chimica Generale e Organica "A.Marchesini", University of Milan, Milan 20133, Italy.Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, CNBS, University of Cagliari, Cagliari 09124, Italy.Dipartimento di Scienze Farmaceutiche-Sezione di Chimica Generale e Organica "A.Marchesini", University of Milan, Milan 20133, Italy.Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, CNBS, University of Cagliari, Cagliari 09124, Italy.Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, CNBS, University of Cagliari, Cagliari 09124, Italy. Electronic address: mfadda@unica.it.Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze del Farmaco, CNBS, University of Cagliari, Cagliari 09124, Italy.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24680963

Citation

Lai, Francesco, et al. "Formulation Strategy and Evaluation of Nanocrystal Piroxicam Orally Disintegrating Tablets Manufacturing By Freeze-drying." International Journal of Pharmaceutics, vol. 467, no. 1-2, 2014, pp. 27-33.
Lai F, Pini E, Corrias F, et al. Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying. Int J Pharm. 2014;467(1-2):27-33.
Lai, F., Pini, E., Corrias, F., Perricci, J., Manconi, M., Fadda, A. M., & Sinico, C. (2014). Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying. International Journal of Pharmaceutics, 467(1-2), 27-33. https://doi.org/10.1016/j.ijpharm.2014.03.047
Lai F, et al. Formulation Strategy and Evaluation of Nanocrystal Piroxicam Orally Disintegrating Tablets Manufacturing By Freeze-drying. Int J Pharm. 2014 Jun 5;467(1-2):27-33. PubMed PMID: 24680963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying. AU - Lai,Francesco, AU - Pini,Elena, AU - Corrias,Francesco, AU - Perricci,Jacopo, AU - Manconi,Maria, AU - Fadda,Anna Maria, AU - Sinico,Chiara, Y1 - 2014/03/26/ PY - 2014/02/03/received PY - 2014/03/20/revised PY - 2014/03/25/accepted PY - 2014/4/1/entrez PY - 2014/4/1/pubmed PY - 2014/12/17/medline KW - Aspartame (PubChem CID 134601) KW - Croscarmellose (PubChem CID 24748) KW - Excipients KW - Maltodextrin (PubChem CID 5793) KW - Mannitol (PubChemCID 6251) KW - Nanocrystal KW - Nanosuspensions KW - Orally disintegrating tablet KW - Piroxicam KW - Piroxicam (PubChem CID 54676228) KW - Poloxamer 188 (PubChem CID 24751) KW - Xanthan gum (PubChemCID 7107) SP - 27 EP - 33 JF - International journal of pharmaceutics JO - Int J Pharm VL - 467 IS - 1-2 N2 - Piroxicam (PRX) is a non-steroidal anti-inflammatory drug characterized by a poor water solubility and consequently by a low oral bioavailability. In this work, different nanocrystal orally disintegrating tablets (ODT) were prepared to enhance piroxicam dissolution rate and saturation solubility. PRX nanocrystals were prepared by means of high pressure homogenization technique using poloxamer 188 as stabilizer. Three different ODTs were prepared with the same nanosuspension using different excipients in order to study their effect on the PRX dissolution properties. PRX nanocrystal size and zeta potential were determined by photon correlation spectroscopy. Additional characterization of PRX nanocrystal ODT was carried out by infrared spectroscopy, X-ray powder diffractometry, differential scanning calorimetry. Dissolution study was performed in distilled water (pH 5.5) and compared with PRX coarse suspension ODT, PRX/poloxamer 188 physical mixture, bulk PRX samples and a PRX commercial ODT. All PRX nanocrystal ODT formulations showed a higher drug dissolution rate than coarse PRX ODT. PRX nanocrystal ODT prepared using gelatin or croscarmellose as excipient showed a higher PRX dissolution rate compared with the commercial formulation and ODT prepared using xanthan gum. Overall results confirmed that improved PRX dissolution rate is due to the increased surface-to-volume ratio due to the nanosized drug particle but also revealed the important role of different excipients used. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/24680963/Formulation_strategy_and_evaluation_of_nanocrystal_piroxicam_orally_disintegrating_tablets_manufacturing_by_freeze_drying_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(14)00202-6 DB - PRIME DP - Unbound Medicine ER -