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Higher incidence of Epstein-Barr virus-induced lymphocyte transformation in multiple sclerosis.
Acta Neurol Scand 2014; 130(2):90-6AN

Abstract

OBJECTIVES

Epstein-Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability to reactivate EBV.

MATERIAL AND METHODS

MS patients and controls were examined for their B-cell subsets and during 16 weeks for spontaneous lymphocyte transforming events.

RESULTS

MS patients had normal distribution of B-cell subsets, but a significantly higher incidence of B-cell transforming events, which occurred with kinetics similar to controls.

CONCLUSIONS

The higher incidence suggests an increased frequency of latent EBV-infected B cells in MS.

Authors+Show Affiliations

Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24684660

Citation

Tørring, C, et al. "Higher Incidence of Epstein-Barr Virus-induced Lymphocyte Transformation in Multiple Sclerosis." Acta Neurologica Scandinavica, vol. 130, no. 2, 2014, pp. 90-6.
Tørring C, Andreasen C, Gehr N, et al. Higher incidence of Epstein-Barr virus-induced lymphocyte transformation in multiple sclerosis. Acta Neurol Scand. 2014;130(2):90-6.
Tørring, C., Andreasen, C., Gehr, N., Bjerg, L., Petersen, T., & Höllsberg, P. (2014). Higher incidence of Epstein-Barr virus-induced lymphocyte transformation in multiple sclerosis. Acta Neurologica Scandinavica, 130(2), pp. 90-6. doi:10.1111/ane.12249.
Tørring C, et al. Higher Incidence of Epstein-Barr Virus-induced Lymphocyte Transformation in Multiple Sclerosis. Acta Neurol Scand. 2014;130(2):90-6. PubMed PMID: 24684660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher incidence of Epstein-Barr virus-induced lymphocyte transformation in multiple sclerosis. AU - Tørring,C, AU - Andreasen,C, AU - Gehr,N, AU - Bjerg,L, AU - Petersen,T, AU - Höllsberg,P, Y1 - 2014/03/31/ PY - 2014/03/10/accepted PY - 2014/4/2/entrez PY - 2014/4/2/pubmed PY - 2015/1/20/medline KW - Epstein-Barr virus KW - lymphoblastoid cell lines KW - relapsing-remitting multiple sclerosis KW - switched memory B cells SP - 90 EP - 6 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 130 IS - 2 N2 - OBJECTIVES: Epstein-Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability to reactivate EBV. MATERIAL AND METHODS: MS patients and controls were examined for their B-cell subsets and during 16 weeks for spontaneous lymphocyte transforming events. RESULTS: MS patients had normal distribution of B-cell subsets, but a significantly higher incidence of B-cell transforming events, which occurred with kinetics similar to controls. CONCLUSIONS: The higher incidence suggests an increased frequency of latent EBV-infected B cells in MS. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/24684660/Higher_incidence_of_Epstein_Barr_virus_induced_lymphocyte_transformation_in_multiple_sclerosis_ L2 - https://doi.org/10.1111/ane.12249 DB - PRIME DP - Unbound Medicine ER -