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COX-2-derived endocannabinoid metabolites as novel inflammatory mediators.
Trends Pharmacol Sci. 2014 Jun; 35(6):284-92.TP

Abstract

Cyclooxygenase-2 (COX-2) is an enzyme that plays a key role in inflammatory processes. Classically, this enzyme is upregulated in inflammatory situations and is responsible for the generation of prostaglandins (PGs) from arachidonic acid (AA). One lesser-known property of COX-2 is its ability to metabolize the endocannabinoids, N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Endocannabinoid metabolism by COX-2 is not merely a means to terminate their actions. On the contrary, it generates PG analogs, namely PG-glycerol esters (PG-G) for 2-AG and PG-ethanolamides (PG-EA or prostamides) for AEA. Although the formation of these COX-2-derived metabolites of the endocannabinoids has been known for a while, their biological effects remain to be fully elucidated. Recently, several studies have focused on the role of these PG-G or PG-EA in vivo. In this review we take a closer look at the literature concerning these novel bioactive lipids and their role in inflammation.

Authors+Show Affiliations

Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Avenue Emmanuel Mounier 72 (B1.72.01), 1200 Bruxelles, Belgium.Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Avenue Emmanuel Mounier 72 (B1.72.01), 1200 Bruxelles, Belgium. Electronic address: giulio.muccioli@uclouvain.be.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24684963

Citation

Alhouayek, Mireille, and Giulio G. Muccioli. "COX-2-derived Endocannabinoid Metabolites as Novel Inflammatory Mediators." Trends in Pharmacological Sciences, vol. 35, no. 6, 2014, pp. 284-92.
Alhouayek M, Muccioli GG. COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci. 2014;35(6):284-92.
Alhouayek, M., & Muccioli, G. G. (2014). COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends in Pharmacological Sciences, 35(6), 284-92. https://doi.org/10.1016/j.tips.2014.03.001
Alhouayek M, Muccioli GG. COX-2-derived Endocannabinoid Metabolites as Novel Inflammatory Mediators. Trends Pharmacol Sci. 2014;35(6):284-92. PubMed PMID: 24684963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. AU - Alhouayek,Mireille, AU - Muccioli,Giulio G, Y1 - 2014/03/29/ PY - 2014/01/24/received PY - 2014/02/27/revised PY - 2014/03/03/accepted PY - 2014/4/2/entrez PY - 2014/4/2/pubmed PY - 2014/7/12/medline KW - FAAH KW - MAGL KW - anandamide KW - cannabinoid KW - prostaglandin synthase KW - prostanoid SP - 284 EP - 92 JF - Trends in pharmacological sciences JO - Trends Pharmacol Sci VL - 35 IS - 6 N2 - Cyclooxygenase-2 (COX-2) is an enzyme that plays a key role in inflammatory processes. Classically, this enzyme is upregulated in inflammatory situations and is responsible for the generation of prostaglandins (PGs) from arachidonic acid (AA). One lesser-known property of COX-2 is its ability to metabolize the endocannabinoids, N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Endocannabinoid metabolism by COX-2 is not merely a means to terminate their actions. On the contrary, it generates PG analogs, namely PG-glycerol esters (PG-G) for 2-AG and PG-ethanolamides (PG-EA or prostamides) for AEA. Although the formation of these COX-2-derived metabolites of the endocannabinoids has been known for a while, their biological effects remain to be fully elucidated. Recently, several studies have focused on the role of these PG-G or PG-EA in vivo. In this review we take a closer look at the literature concerning these novel bioactive lipids and their role in inflammation. SN - 1873-3735 UR - https://www.unboundmedicine.com/medline/citation/24684963/COX_2_derived_endocannabinoid_metabolites_as_novel_inflammatory_mediators_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-6147(14)00035-2 DB - PRIME DP - Unbound Medicine ER -