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Vitamin D levels and obstructive sleep apnoea in children.
Sleep Med. 2014 Apr; 15(4):459-63.SM

Abstract

AIMS/HYPOTHESIS

Obstructive sleep apnoea (OSA) is a common health problem in children. African American (AA) and obese children have higher prevalence of OSA, and are also at a higher risk of reduced vitamin D levels. We hypothesised that OSA would be associated with lower levels of plasma 25-hydroxyvitamin D (25(OH)D) and increase in the risk of metabolic dysfunction and systemic inflammation.

METHODS

In this observational cross-sectional study, 176 prospectively recruited children (mean age: 6.8±0.8 years) underwent overnight polysomnographic evaluation and a fasting blood draw the morning after the sleep study. In addition to lipid profile, homeostatic model of insulin resistance (HOMA-IR) and high-sensitivity C-reactive protein (hsCRP) assays and plasma 25(OH)D levels were assessed using ELISA kits.

RESULTS

AA children, obese children and children with OSA had significantly lower 25(OH)D levels. Linear associations emerged between 25(OH)D plasma levels and body mass index (BMI) z-score, hsCRP and HOMA-IR, as well as with apnoea-hypopnoea index (AHI) and oxygen saturation (SpO2) nadir, the latter two associations remaining statistically significant even when controlling for all other potential confounders, and independently accounting for 17.7% of the variance in 25(OH)D (p<0.01).

CONCLUSIONS

25(OH)D levels are reduced in paediatric OSA, in AA children and in obese children, particularly when all are present, and may play a role in modulating the degree of insulin resistance and systemic inflammation. The short-term and long-term significance of reduced 25(OH)D in paediatric OSA remains undefined.

Authors+Show Affiliations

Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA. Electronic address: lgozal@peds.bsd.uchicago.edu.Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA. Electronic address: dgozal@uchicago.edu.

Pub Type(s)

Journal Article
Observational Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24684979

Citation

Kheirandish-Gozal, Leila, et al. "Vitamin D Levels and Obstructive Sleep Apnoea in Children." Sleep Medicine, vol. 15, no. 4, 2014, pp. 459-63.
Kheirandish-Gozal L, Peris E, Gozal D. Vitamin D levels and obstructive sleep apnoea in children. Sleep Med. 2014;15(4):459-63.
Kheirandish-Gozal, L., Peris, E., & Gozal, D. (2014). Vitamin D levels and obstructive sleep apnoea in children. Sleep Medicine, 15(4), 459-63. https://doi.org/10.1016/j.sleep.2013.12.009
Kheirandish-Gozal L, Peris E, Gozal D. Vitamin D Levels and Obstructive Sleep Apnoea in Children. Sleep Med. 2014;15(4):459-63. PubMed PMID: 24684979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D levels and obstructive sleep apnoea in children. AU - Kheirandish-Gozal,Leila, AU - Peris,Eduard, AU - Gozal,David, Y1 - 2014/02/07/ PY - 2013/09/12/received PY - 2013/12/14/revised PY - 2013/12/17/accepted PY - 2014/4/2/entrez PY - 2014/4/2/pubmed PY - 2014/12/15/medline KW - Children KW - Insulin resistance KW - Metabolism KW - Sleep apnoea KW - Systemic inflammation KW - Vitamin D SP - 459 EP - 63 JF - Sleep medicine JO - Sleep Med. VL - 15 IS - 4 N2 - AIMS/HYPOTHESIS: Obstructive sleep apnoea (OSA) is a common health problem in children. African American (AA) and obese children have higher prevalence of OSA, and are also at a higher risk of reduced vitamin D levels. We hypothesised that OSA would be associated with lower levels of plasma 25-hydroxyvitamin D (25(OH)D) and increase in the risk of metabolic dysfunction and systemic inflammation. METHODS: In this observational cross-sectional study, 176 prospectively recruited children (mean age: 6.8±0.8 years) underwent overnight polysomnographic evaluation and a fasting blood draw the morning after the sleep study. In addition to lipid profile, homeostatic model of insulin resistance (HOMA-IR) and high-sensitivity C-reactive protein (hsCRP) assays and plasma 25(OH)D levels were assessed using ELISA kits. RESULTS: AA children, obese children and children with OSA had significantly lower 25(OH)D levels. Linear associations emerged between 25(OH)D plasma levels and body mass index (BMI) z-score, hsCRP and HOMA-IR, as well as with apnoea-hypopnoea index (AHI) and oxygen saturation (SpO2) nadir, the latter two associations remaining statistically significant even when controlling for all other potential confounders, and independently accounting for 17.7% of the variance in 25(OH)D (p<0.01). CONCLUSIONS: 25(OH)D levels are reduced in paediatric OSA, in AA children and in obese children, particularly when all are present, and may play a role in modulating the degree of insulin resistance and systemic inflammation. The short-term and long-term significance of reduced 25(OH)D in paediatric OSA remains undefined. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/24684979/Vitamin_D_levels_and_obstructive_sleep_apnoea_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(14)00038-0 DB - PRIME DP - Unbound Medicine ER -