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Xanthone glycosides from Swertia bimaculata with α-glucosidase inhibitory activity.
Planta Med. 2014 Apr; 80(6):502-8.PM

Abstract

Seven new xanthone glycosides (1-7) were isolated from the n-butanol extract of Swertia bimaculata, together with six known compounds (8-13). Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. All the compounds were evaluated for their α-glucosidase inhibitory activities in vitro, and compounds 3, 4, and 7 exhibited significant activities to inhibit α-glucosidase. Meanwhile the effects of different substitutions on the α-glucosidase inhibitory activity of xanthone glycosides from S. bimaculata are also discussed.

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Authors+Show Affiliations

Yue YD
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Zhang YT
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Liu ZX
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Min QX
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Wan LS
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Wang YL
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Xiao ZQ
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Chen JC
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

MeSH

Enzyme InhibitorsGlycosidesMolecular StructurePlant ExtractsSwertiaXanthonesalpha-Glucosidases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24687743

Citation

Yue, Yao-Dong, et al. "Xanthone Glycosides From Swertia Bimaculata With Α-glucosidase Inhibitory Activity." Planta Medica, vol. 80, no. 6, 2014, pp. 502-8.
Yue YD, Zhang YT, Liu ZX, et al. Xanthone glycosides from Swertia bimaculata with α-glucosidase inhibitory activity. Planta Med. 2014;80(6):502-8.
Yue, Y. D., Zhang, Y. T., Liu, Z. X., Min, Q. X., Wan, L. S., Wang, Y. L., Xiao, Z. Q., & Chen, J. C. (2014). Xanthone glycosides from Swertia bimaculata with α-glucosidase inhibitory activity. Planta Medica, 80(6), 502-8. https://doi.org/10.1055/s-0034-1368299
Yue YD, et al. Xanthone Glycosides From Swertia Bimaculata With Α-glucosidase Inhibitory Activity. Planta Med. 2014;80(6):502-8. PubMed PMID: 24687743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthone glycosides from Swertia bimaculata with α-glucosidase inhibitory activity. AU - Yue,Yao-Dong, AU - Zhang,Yu-Tang, AU - Liu,Zhao-Xia, AU - Min,Qiu-Xia, AU - Wan,Luo-Sheng, AU - Wang,Yong-Long, AU - Xiao,Zuo-Qi, AU - Chen,Jia-Chun, Y1 - 2014/03/31/ PY - 2014/4/2/entrez PY - 2014/4/2/pubmed PY - 2014/12/17/medline SP - 502 EP - 8 JF - Planta medica JO - Planta Med VL - 80 IS - 6 N2 - Seven new xanthone glycosides (1-7) were isolated from the n-butanol extract of Swertia bimaculata, together with six known compounds (8-13). Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. All the compounds were evaluated for their α-glucosidase inhibitory activities in vitro, and compounds 3, 4, and 7 exhibited significant activities to inhibit α-glucosidase. Meanwhile the effects of different substitutions on the α-glucosidase inhibitory activity of xanthone glycosides from S. bimaculata are also discussed. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/24687743/Xanthone_glycosides_from_Swertia_bimaculata_with_α_glucosidase_inhibitory_activity_ DB - PRIME DP - Unbound Medicine ER -