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Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional study.
Hum Brain Mapp 2014; 35(9):4706-17HB

Abstract

Severe cognitive impairment involving multiple cognitive domains can occur early during the course of multiple sclerosis (MS). We investigated resting state functional connectivity changes in large-scale brain networks and related structural damage underlying cognitive dysfunction in patients with early MS. Patients with relapsing MS (3-5 years disease duration) were prospectively assigned to two groups based on a standardized neuropsychological evaluation: (1) cognitively impaired group (CI group, n = 15), with abnormal performances in at least 3 tests; (2) cognitively preserved group (CP group, n = 20) with normal performances in all tests. Patients and age-matched healthy controls underwent a multimodal 3T magnetic resonance imaging (MRI) including anatomical T1 and T2 images, diffusion imaging and resting state functional MRI. Structural MRI analysis revealed that CI patients had a higher white matter lesion load compared to CP and a more severe atrophy in gray matter regions highly connected to networks involved in cognition. Functional connectivity measured by integration was increased in CP patients versus controls in attentional networks (ATT), while integration was decreased in CI patients compared to CP both in the default mode network (DMN) and ATT. An anatomofunctional study within the DMN revealed that functional connectivity was mostly altered between the medial prefrontal cortex (MPFC) and the posterior cingulate cortex (PCC) in CI patients compared to CP and controls. In a multilinear regression model, functional correlation between MPFC and PCC was best predicted by PCC atrophy. Disconnection in the DMN and ATT networks may deprive the brain of compensatory mechanisms required to face widespread structural damage.

Authors+Show Affiliations

Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, F-75013, France; Inserm, U975, Paris, F-75013, France; CNRS, UMR 7225, Paris, France; AP-HP, Hôpital de la Salpêtrière, Hôpital Tenon, F-75020, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24687771

Citation

Louapre, Céline, et al. "Brain Networks Disconnection in Early Multiple Sclerosis Cognitive Deficits: an Anatomofunctional Study." Human Brain Mapping, vol. 35, no. 9, 2014, pp. 4706-17.
Louapre C, Perlbarg V, García-Lorenzo D, et al. Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional study. Hum Brain Mapp. 2014;35(9):4706-17.
Louapre, C., Perlbarg, V., García-Lorenzo, D., Urbanski, M., Benali, H., Assouad, R., ... Stankoff, B. (2014). Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional study. Human Brain Mapping, 35(9), pp. 4706-17. doi:10.1002/hbm.22505.
Louapre C, et al. Brain Networks Disconnection in Early Multiple Sclerosis Cognitive Deficits: an Anatomofunctional Study. Hum Brain Mapp. 2014;35(9):4706-17. PubMed PMID: 24687771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional study. AU - Louapre,Céline, AU - Perlbarg,Vincent, AU - García-Lorenzo,Daniel, AU - Urbanski,Marika, AU - Benali,Habib, AU - Assouad,Rana, AU - Galanaud,Damien, AU - Freeman,Léorah, AU - Bodini,Benedetta, AU - Papeix,Caroline, AU - Tourbah,Ayman, AU - Lubetzki,Catherine, AU - Lehéricy,Stéphane, AU - Stankoff,Bruno, Y1 - 2014/03/31/ PY - 2013/05/01/received PY - 2014/02/22/revised PY - 2014/02/25/accepted PY - 2014/4/2/entrez PY - 2014/4/2/pubmed PY - 2015/3/7/medline KW - MRI KW - cognition KW - default mode network KW - multiple sclerosis KW - resting state SP - 4706 EP - 17 JF - Human brain mapping JO - Hum Brain Mapp VL - 35 IS - 9 N2 - Severe cognitive impairment involving multiple cognitive domains can occur early during the course of multiple sclerosis (MS). We investigated resting state functional connectivity changes in large-scale brain networks and related structural damage underlying cognitive dysfunction in patients with early MS. Patients with relapsing MS (3-5 years disease duration) were prospectively assigned to two groups based on a standardized neuropsychological evaluation: (1) cognitively impaired group (CI group, n = 15), with abnormal performances in at least 3 tests; (2) cognitively preserved group (CP group, n = 20) with normal performances in all tests. Patients and age-matched healthy controls underwent a multimodal 3T magnetic resonance imaging (MRI) including anatomical T1 and T2 images, diffusion imaging and resting state functional MRI. Structural MRI analysis revealed that CI patients had a higher white matter lesion load compared to CP and a more severe atrophy in gray matter regions highly connected to networks involved in cognition. Functional connectivity measured by integration was increased in CP patients versus controls in attentional networks (ATT), while integration was decreased in CI patients compared to CP both in the default mode network (DMN) and ATT. An anatomofunctional study within the DMN revealed that functional connectivity was mostly altered between the medial prefrontal cortex (MPFC) and the posterior cingulate cortex (PCC) in CI patients compared to CP and controls. In a multilinear regression model, functional correlation between MPFC and PCC was best predicted by PCC atrophy. Disconnection in the DMN and ATT networks may deprive the brain of compensatory mechanisms required to face widespread structural damage. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/24687771/Brain_networks_disconnection_in_early_multiple_sclerosis_cognitive_deficits:_an_anatomofunctional_study_ L2 - https://doi.org/10.1002/hbm.22505 DB - PRIME DP - Unbound Medicine ER -