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Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species.
J Clin Biochem Nutr. 2014 Mar; 54(2):67-74.JC

Abstract

Scavenging rate constants of eight hydrophilic antioxidants, including caffeic acid, chlorogenic acid, genistein, glutathione, N-acetylcysteine, rutin, trolox, and uric acid against multiple ROS, namely superoxide anion, hydroxyl radical, singlet oxygen, and alkoxyl radical were determined with the electron spin resonance method. Direct flash photolysis measurement of the second-order rate constant in the reaction of alkoxyl radical plus the spin trap 5,5-dimethyl-pyrroline N-oxide made it possible to evaluate scavenging rate constants in antioxidants. The magnitudes of scavenging rate constants were notably dependent on the character of each ROS and the overall rate constants were highest in hydroxyl radical scavenging and the lowest in superoxide anion. The highest scavenging rate constant against superoxide anion was obtained by chlorogenic acid (2.9 × 10(5) M(-1) s(-1)) and the lowest was by N-acetylcysteine (5.0 × 10(2) M(-1) s(-1)). For singlet oxygen, the highest was by glutathione (9.4 × 10(8) M(-1) s(-1)) and the lowest was by uric acid (2.3 × 10(6) M(-1) s(-1)). All other numbers are listed and illustrated. Redox potential measurements of the antioxidants indicated that the antioxidants are likely to react with superoxide anion and singlet oxygen through electron transfer processes.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Graduate School of Education, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.Graduate School of Science and Engineering, Ehime University, Matsuyama 790-8577, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24688213

Citation

Sueishi, Yoshimi, et al. "Scavenging Rate Constants of Hydrophilic Antioxidants Against Multiple Reactive Oxygen Species." Journal of Clinical Biochemistry and Nutrition, vol. 54, no. 2, 2014, pp. 67-74.
Sueishi Y, Hori M, Ishikawa M, et al. Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species. J Clin Biochem Nutr. 2014;54(2):67-74.
Sueishi, Y., Hori, M., Ishikawa, M., Matsu-Ura, K., Kamogawa, E., Honda, Y., Kita, M., & Ohara, K. (2014). Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species. Journal of Clinical Biochemistry and Nutrition, 54(2), 67-74. https://doi.org/10.3164/jcbn.13-53
Sueishi Y, et al. Scavenging Rate Constants of Hydrophilic Antioxidants Against Multiple Reactive Oxygen Species. J Clin Biochem Nutr. 2014;54(2):67-74. PubMed PMID: 24688213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species. AU - Sueishi,Yoshimi, AU - Hori,Masashi, AU - Ishikawa,Misa, AU - Matsu-Ura,Keiko, AU - Kamogawa,Erisa, AU - Honda,Yusaku, AU - Kita,Masakazu, AU - Ohara,Keishi, Y1 - 2014/02/21/ PY - 2013/07/02/received PY - 2013/09/23/accepted PY - 2014/4/2/entrez PY - 2014/4/2/pubmed PY - 2014/4/2/medline KW - hydrophilic antioxidant KW - radical scavenging KW - reactive oxygen species (ROS) KW - redox potential KW - spin trapping SP - 67 EP - 74 JF - Journal of clinical biochemistry and nutrition JO - J Clin Biochem Nutr VL - 54 IS - 2 N2 - Scavenging rate constants of eight hydrophilic antioxidants, including caffeic acid, chlorogenic acid, genistein, glutathione, N-acetylcysteine, rutin, trolox, and uric acid against multiple ROS, namely superoxide anion, hydroxyl radical, singlet oxygen, and alkoxyl radical were determined with the electron spin resonance method. Direct flash photolysis measurement of the second-order rate constant in the reaction of alkoxyl radical plus the spin trap 5,5-dimethyl-pyrroline N-oxide made it possible to evaluate scavenging rate constants in antioxidants. The magnitudes of scavenging rate constants were notably dependent on the character of each ROS and the overall rate constants were highest in hydroxyl radical scavenging and the lowest in superoxide anion. The highest scavenging rate constant against superoxide anion was obtained by chlorogenic acid (2.9 × 10(5) M(-1) s(-1)) and the lowest was by N-acetylcysteine (5.0 × 10(2) M(-1) s(-1)). For singlet oxygen, the highest was by glutathione (9.4 × 10(8) M(-1) s(-1)) and the lowest was by uric acid (2.3 × 10(6) M(-1) s(-1)). All other numbers are listed and illustrated. Redox potential measurements of the antioxidants indicated that the antioxidants are likely to react with superoxide anion and singlet oxygen through electron transfer processes. SN - 0912-0009 UR - https://www.unboundmedicine.com/medline/citation/24688213/Scavenging_rate_constants_of_hydrophilic_antioxidants_against_multiple_reactive_oxygen_species_ L2 - https://dx.doi.org/10.3164/jcbn.13-53 DB - PRIME DP - Unbound Medicine ER -
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