Tags

Type your tag names separated by a space and hit enter

Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice.
Molecules. 2014 Mar 31; 19(4):3926-39.M

Abstract

Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n=10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training.

Authors+Show Affiliations

School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan.Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan.National Laboratory Animal Center, National Applied Research Laboratories, Taipei 11529, Taiwan.Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. meichich@kmu.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24691065

Citation

Yeh, Tzu-Shao, et al. "Angelica Sinensis Improves Exercise Performance and Protects Against Physical Fatigue in Trained Mice." Molecules (Basel, Switzerland), vol. 19, no. 4, 2014, pp. 3926-39.
Yeh TS, Huang CC, Chuang HL, et al. Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice. Molecules. 2014;19(4):3926-39.
Yeh, T. S., Huang, C. C., Chuang, H. L., & Hsu, M. C. (2014). Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice. Molecules (Basel, Switzerland), 19(4), 3926-39. https://doi.org/10.3390/molecules19043926
Yeh TS, et al. Angelica Sinensis Improves Exercise Performance and Protects Against Physical Fatigue in Trained Mice. Molecules. 2014 Mar 31;19(4):3926-39. PubMed PMID: 24691065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice. AU - Yeh,Tzu-Shao, AU - Huang,Chi-Chang, AU - Chuang,Hsiao-Li, AU - Hsu,Mei-Chich, Y1 - 2014/03/31/ PY - 2014/02/09/received PY - 2014/03/03/revised PY - 2014/03/17/accepted PY - 2014/4/3/entrez PY - 2014/4/3/pubmed PY - 2014/12/15/medline SP - 3926 EP - 39 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 19 IS - 4 N2 - Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n=10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/24691065/Angelica_sinensis_improves_exercise_performance_and_protects_against_physical_fatigue_in_trained_mice_ L2 - http://www.mdpi.com/resolver?pii=molecules19043926 DB - PRIME DP - Unbound Medicine ER -