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Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis.
Inflamm Bowel Dis 2014; 20(6):1110-9IB

Abstract

Inadequate dietary intake of the essential trace element selenium (Se) is thought to be a risk factor for several chronic diseases associated with oxidative stress and inflammation. Biological actions of Se occur through low-molecular weight metabolites and through selenoproteins. Several key selenoproteins including glutathione peroxidases; selenoproteins M, P, and S; and selenium-binding protein 1 have been detected in the intestine. Interestingly, Se and antioxidant selenoproteins are known to modulate differentiation and function of immune cells and contribute to avoid excessive immune responses. This review discusses the role of Se and intestinal selenoproteins in inflammatory bowel diseases, based on data from human, animal, and in vitro studies. In humans, Se deficiency is commonly observed in patients with Crohn's disease. In animal models of experimental colitis, the Se status was negatively correlated with the severity of the disease. While the cause-effect relationship of these observations remains to be clarified, the beneficial outcome of dietary Se supplementation and an optimization of selenoprotein biosynthesis in murine inflammatory bowel disease models have led to investigations of targets and actions of Se in the gastrointestinal tract. The Se status affects gene expression, signaling pathways, and cellular functions in the small and large intestine as well as the gut microbiome composition. This data, particularly from animal experiments, hold promise that adequate dietary Se supply may counteract chronic intestinal inflammation in humans.

Authors+Show Affiliations

Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University, Düsseldorf, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24694793

Citation

Speckmann, Bodo, and Holger Steinbrenner. "Selenium and Selenoproteins in Inflammatory Bowel Diseases and Experimental Colitis." Inflammatory Bowel Diseases, vol. 20, no. 6, 2014, pp. 1110-9.
Speckmann B, Steinbrenner H. Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis. Inflamm Bowel Dis. 2014;20(6):1110-9.
Speckmann, B., & Steinbrenner, H. (2014). Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis. Inflammatory Bowel Diseases, 20(6), pp. 1110-9. doi:10.1097/MIB.0000000000000020.
Speckmann B, Steinbrenner H. Selenium and Selenoproteins in Inflammatory Bowel Diseases and Experimental Colitis. Inflamm Bowel Dis. 2014;20(6):1110-9. PubMed PMID: 24694793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis. AU - Speckmann,Bodo, AU - Steinbrenner,Holger, PY - 2014/4/4/entrez PY - 2014/4/4/pubmed PY - 2014/12/30/medline SP - 1110 EP - 9 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 20 IS - 6 N2 - Inadequate dietary intake of the essential trace element selenium (Se) is thought to be a risk factor for several chronic diseases associated with oxidative stress and inflammation. Biological actions of Se occur through low-molecular weight metabolites and through selenoproteins. Several key selenoproteins including glutathione peroxidases; selenoproteins M, P, and S; and selenium-binding protein 1 have been detected in the intestine. Interestingly, Se and antioxidant selenoproteins are known to modulate differentiation and function of immune cells and contribute to avoid excessive immune responses. This review discusses the role of Se and intestinal selenoproteins in inflammatory bowel diseases, based on data from human, animal, and in vitro studies. In humans, Se deficiency is commonly observed in patients with Crohn's disease. In animal models of experimental colitis, the Se status was negatively correlated with the severity of the disease. While the cause-effect relationship of these observations remains to be clarified, the beneficial outcome of dietary Se supplementation and an optimization of selenoprotein biosynthesis in murine inflammatory bowel disease models have led to investigations of targets and actions of Se in the gastrointestinal tract. The Se status affects gene expression, signaling pathways, and cellular functions in the small and large intestine as well as the gut microbiome composition. This data, particularly from animal experiments, hold promise that adequate dietary Se supply may counteract chronic intestinal inflammation in humans. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/24694793/Selenium_and_selenoproteins_in_inflammatory_bowel_diseases_and_experimental_colitis_ L2 - https://academic.oup.com/ibdjournal/article-lookup/doi/10.1097/MIB.0000000000000020 DB - PRIME DP - Unbound Medicine ER -