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Dietary calcium does not interact with vitamin D₃ in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults.
Am J Clin Nutr. 2014 Jun; 99(6):1414-23.AJ

Abstract

BACKGROUND

Interactions between calcium and vitamin D may have implications for the regulation of serum 25-hydroxyvitamin D [25(OH)D] and its catabolism and, consequently, the vitamin D dietary requirement.

OBJECTIVE

We investigated whether different calcium intakes influenced serum 25(OH)D and indexes of vitamin D activation and catabolism during winter and in the context of both adequate and inadequate vitamin D intakes.

DESIGN

A 15-wk winter-based, randomized, placebo-controlled, double-blind vitamin D₃ intervention (20 μg/d) study was carried out in free-living men and women aged ≥50 y (n = 125) who were stratified according to calcium intakes [moderate-low (<700 mg/d) or high (>1000 mg/d) intake]. The serum 25(OH)D concentration was the primary outcome, and serum calcium, parathyroid hormone (PTH), 1,25-dihydroxyvitamin D [1,25(OH)₂D], 24,25-dihydroxyvitamin D [24,25(OH)₂D], the ratio of 24,25(OH)₂D to 25(OH)D, vitamin D-binding protein, and free 25(OH)D were exploratory outcomes.

RESULTS

A repeated-measures ANOVA showed there was no significant (P = 0.2) time × vitamin D treatment × calcium intake grouping interaction effect on the mean serum 25(OH)D concentration over the 15-wk intervention period. Serum 25(OH)D concentrations increased (P ≤ 0.005) and decreased (P ≤ 0.002) in vitamin D₃ and placebo groups, respectively, and were of similar magnitudes in subjects with calcium intakes <700 mg/d (and even <550 mg/d) compared with >1000 mg/d. The response of serum PTH, 1,25(OH)₂D, 24,25(OH)₂D, the ratio of 24,25(OH)₂D to 25(OH)D, and free 25(OH)D significantly differed in vitamin D₃ and placebo groups but not by calcium intake grouping.

CONCLUSIONS

We found no evidence of a vitamin D sparing effect of high calcium intake, which has been referred to by some authors as "vitamin D economy." Thus, recent dietary vitamin D requirement estimates will cover the vitamin D needs of even those individuals who have inadequate calcium intakes.

Authors+Show Affiliations

From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.From the School of Food and Nutritional Sciences (KMS, AH, SMO, JYZ, M Kinsella, KG, M Kiely, and KDC) and the Department of Medicine (KDC), University College Cork, Cork, Ireland.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24695896

Citation

Cashman, Kevin D., et al. "Dietary Calcium Does Not Interact With Vitamin D₃ in Terms of Determining the Response and Catabolism of Serum 25-hydroxyvitamin D During Winter in Older Adults." The American Journal of Clinical Nutrition, vol. 99, no. 6, 2014, pp. 1414-23.
Cashman KD, Hayes A, O'Donovan SM, et al. Dietary calcium does not interact with vitamin D₃ in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults. Am J Clin Nutr. 2014;99(6):1414-23.
Cashman, K. D., Hayes, A., O'Donovan, S. M., Zhang, J. Y., Kinsella, M., Galvin, K., Kiely, M., & Seamans, K. M. (2014). Dietary calcium does not interact with vitamin D₃ in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults. The American Journal of Clinical Nutrition, 99(6), 1414-23. https://doi.org/10.3945/ajcn.113.080358
Cashman KD, et al. Dietary Calcium Does Not Interact With Vitamin D₃ in Terms of Determining the Response and Catabolism of Serum 25-hydroxyvitamin D During Winter in Older Adults. Am J Clin Nutr. 2014;99(6):1414-23. PubMed PMID: 24695896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary calcium does not interact with vitamin D₃ in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults. AU - Cashman,Kevin D, AU - Hayes,Aoife, AU - O'Donovan,Sinead M, AU - Zhang,Joy Y, AU - Kinsella,Michael, AU - Galvin,Karen, AU - Kiely,Mairead, AU - Seamans,Kelly M, Y1 - 2014/04/02/ PY - 2014/4/4/entrez PY - 2014/4/4/pubmed PY - 2015/4/22/medline SP - 1414 EP - 23 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 99 IS - 6 N2 - BACKGROUND: Interactions between calcium and vitamin D may have implications for the regulation of serum 25-hydroxyvitamin D [25(OH)D] and its catabolism and, consequently, the vitamin D dietary requirement. OBJECTIVE: We investigated whether different calcium intakes influenced serum 25(OH)D and indexes of vitamin D activation and catabolism during winter and in the context of both adequate and inadequate vitamin D intakes. DESIGN: A 15-wk winter-based, randomized, placebo-controlled, double-blind vitamin D₃ intervention (20 μg/d) study was carried out in free-living men and women aged ≥50 y (n = 125) who were stratified according to calcium intakes [moderate-low (<700 mg/d) or high (>1000 mg/d) intake]. The serum 25(OH)D concentration was the primary outcome, and serum calcium, parathyroid hormone (PTH), 1,25-dihydroxyvitamin D [1,25(OH)₂D], 24,25-dihydroxyvitamin D [24,25(OH)₂D], the ratio of 24,25(OH)₂D to 25(OH)D, vitamin D-binding protein, and free 25(OH)D were exploratory outcomes. RESULTS: A repeated-measures ANOVA showed there was no significant (P = 0.2) time × vitamin D treatment × calcium intake grouping interaction effect on the mean serum 25(OH)D concentration over the 15-wk intervention period. Serum 25(OH)D concentrations increased (P ≤ 0.005) and decreased (P ≤ 0.002) in vitamin D₃ and placebo groups, respectively, and were of similar magnitudes in subjects with calcium intakes <700 mg/d (and even <550 mg/d) compared with >1000 mg/d. The response of serum PTH, 1,25(OH)₂D, 24,25(OH)₂D, the ratio of 24,25(OH)₂D to 25(OH)D, and free 25(OH)D significantly differed in vitamin D₃ and placebo groups but not by calcium intake grouping. CONCLUSIONS: We found no evidence of a vitamin D sparing effect of high calcium intake, which has been referred to by some authors as "vitamin D economy." Thus, recent dietary vitamin D requirement estimates will cover the vitamin D needs of even those individuals who have inadequate calcium intakes. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24695896/Dietary_calcium_does_not_interact_with_vitamin_D₃_in_terms_of_determining_the_response_and_catabolism_of_serum_25_hydroxyvitamin_D_during_winter_in_older_adults_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.080358 DB - PRIME DP - Unbound Medicine ER -