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Primary cutaneous B-cell lymphoma with abundant reactive gamma/delta T-cells within the skin lesion and peripheral blood.
Int J Clin Exp Pathol 2014; 7(3):1193-9IJ

Abstract

T-cell/histiocyte-rich diffuse large B-cell lymphoma is characterized by abundant reactive T-cell and histiocyte infiltration within nodal diffuse large B-cell lymphoma, and only limited cases of primary cutaneous T-cell-rich B-cell lymphoma have been documented. These reactive T-cells usually show a T-helper phenotype. Gamma/delta T-cell is a functionally distinct T-cell lineage, which constitutes on average 5% of all T-cells in the peripheral blood. Herein, we report the first documented case of primary cutaneous malignant B-cell lymphoma with abundant reactive gamma/delta(+) T-cells within the skin lesion and peripheral blood. An 80-year-old Japanese male presented with a gradually enlarged knee nodule. Histopathological study revealed diffuse infiltration of lymphoid cells in the dermis and subcutis. Proliferation of large-sized atypical lymphoid cells was observed among medium-sized lymphocytes with convoluted nuclei. Immunohistochemically, these large-sized atypical lymphocytes were CD20(+), and relatively many gamma/delta(+) cell infiltration was also noted. Flowcytometric analysis revealed deviation of lambda+ cells (lambda/kappa 58) and increase of CD3(+) gamma/delta(+) cells (6%). Peripheral blood had CD3(+) gamma/delta(+) cells (28.8%). Rearrangement of immunoglobulin heavy chain, but not of T-cell receptor beta and gamma chains, was observed. Accordingly, an ultimate diagnosis of cutaneous B-cell lymphoma with abundant reactive gamma/delta(+) cells was made. Recent studies have shown reactive gamma/delta(+) T-cell infiltration and/or elevation in the peripheral blood in patients with various types of carcinoma, and that they play a role in the pathogenesis of some carcinomas. Therefore, additional analysis is needed to clarify the role of reactive gamma/delta(+) T-cells in malignant lymphoma.

Authors+Show Affiliations

Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science Shiga, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24696737

Citation

Ishida, Mitsuaki, et al. "Primary Cutaneous B-cell Lymphoma With Abundant Reactive Gamma/delta T-cells Within the Skin Lesion and Peripheral Blood." International Journal of Clinical and Experimental Pathology, vol. 7, no. 3, 2014, pp. 1193-9.
Ishida M, Iwai M, Yoshida K, et al. Primary cutaneous B-cell lymphoma with abundant reactive gamma/delta T-cells within the skin lesion and peripheral blood. Int J Clin Exp Pathol. 2014;7(3):1193-9.
Ishida, M., Iwai, M., Yoshida, K., Kagotani, A., & Okabe, H. (2014). Primary cutaneous B-cell lymphoma with abundant reactive gamma/delta T-cells within the skin lesion and peripheral blood. International Journal of Clinical and Experimental Pathology, 7(3), pp. 1193-9.
Ishida M, et al. Primary Cutaneous B-cell Lymphoma With Abundant Reactive Gamma/delta T-cells Within the Skin Lesion and Peripheral Blood. Int J Clin Exp Pathol. 2014;7(3):1193-9. PubMed PMID: 24696737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary cutaneous B-cell lymphoma with abundant reactive gamma/delta T-cells within the skin lesion and peripheral blood. AU - Ishida,Mitsuaki, AU - Iwai,Muneo, AU - Yoshida,Keiko, AU - Kagotani,Akiko, AU - Okabe,Hidetoshi, Y1 - 2014/02/15/ PY - 2013/12/10/received PY - 2014/01/08/accepted PY - 2014/4/4/entrez PY - 2014/4/4/pubmed PY - 2014/12/20/medline KW - Cutaneous B-cell lymphoma KW - T-cell-rich B-cell lymphoma KW - gamma/delta T-cell SP - 1193 EP - 9 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 7 IS - 3 N2 - T-cell/histiocyte-rich diffuse large B-cell lymphoma is characterized by abundant reactive T-cell and histiocyte infiltration within nodal diffuse large B-cell lymphoma, and only limited cases of primary cutaneous T-cell-rich B-cell lymphoma have been documented. These reactive T-cells usually show a T-helper phenotype. Gamma/delta T-cell is a functionally distinct T-cell lineage, which constitutes on average 5% of all T-cells in the peripheral blood. Herein, we report the first documented case of primary cutaneous malignant B-cell lymphoma with abundant reactive gamma/delta(+) T-cells within the skin lesion and peripheral blood. An 80-year-old Japanese male presented with a gradually enlarged knee nodule. Histopathological study revealed diffuse infiltration of lymphoid cells in the dermis and subcutis. Proliferation of large-sized atypical lymphoid cells was observed among medium-sized lymphocytes with convoluted nuclei. Immunohistochemically, these large-sized atypical lymphocytes were CD20(+), and relatively many gamma/delta(+) cell infiltration was also noted. Flowcytometric analysis revealed deviation of lambda+ cells (lambda/kappa 58) and increase of CD3(+) gamma/delta(+) cells (6%). Peripheral blood had CD3(+) gamma/delta(+) cells (28.8%). Rearrangement of immunoglobulin heavy chain, but not of T-cell receptor beta and gamma chains, was observed. Accordingly, an ultimate diagnosis of cutaneous B-cell lymphoma with abundant reactive gamma/delta(+) cells was made. Recent studies have shown reactive gamma/delta(+) T-cell infiltration and/or elevation in the peripheral blood in patients with various types of carcinoma, and that they play a role in the pathogenesis of some carcinomas. Therefore, additional analysis is needed to clarify the role of reactive gamma/delta(+) T-cells in malignant lymphoma. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/24696737/Primary_cutaneous_B_cell_lymphoma_with_abundant_reactive_gamma/delta_T_cells_within_the_skin_lesion_and_peripheral_blood_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24696737/ DB - PRIME DP - Unbound Medicine ER -