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Composition and biological activities of hogweed [Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt] essential oil and its main components octyl acetate and octyl butyrate.
Nat Prod Res. 2014; 28(17):1354-63.NP

Abstract

The essential oil obtained from the fruits of hogweed (Heracleum sphondylium subsp. ternatum) growing in central Apennines (Italy) was analysed for chemical composition by gas chromatographic-flame ionisation detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The oil was composed mainly of aliphatic esters (86.9-89.5%), among them octyl acetate (54.9-60.2%) and octyl butyrate (10.1-13.4%) were the most abundant. The oil and its two major esters, octyl acetate and octyl butyrate, were tested for in vitro biological activity, namely antibacterial, antioxidant and cytotoxic, by microdilution, DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assays. Worthy of mention was only the cytotoxic activity of the oil against two tumour cell lines, i.e. A375 (human malignant melanoma) and HCT116 (human colon carcinoma) cells, with IC50 values of 48.69 and 95.83 μg/mL, respectively; the major compound responsible for this effect was octyl butyrate which displayed IC50 values of 20.19 μg/mL (100.8 μM) and 55.35 μg/mL (276.3 μM) on the same cells, respectively.

Authors+Show Affiliations

a School of Pharmacy, University of Camerino , I-62032 Camerino , Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24697288

Citation

Maggi, Filippo, et al. "Composition and Biological Activities of Hogweed [Heracleum Sphondylium L. Subsp. Ternatum (Velen.) Brummitt] Essential Oil and Its Main Components Octyl Acetate and Octyl Butyrate." Natural Product Research, vol. 28, no. 17, 2014, pp. 1354-63.
Maggi F, Quassinti L, Bramucci M, et al. Composition and biological activities of hogweed [Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt] essential oil and its main components octyl acetate and octyl butyrate. Nat Prod Res. 2014;28(17):1354-63.
Maggi, F., Quassinti, L., Bramucci, M., Lupidi, G., Petrelli, D., Vitali, L. A., Papa, F., & Vittori, S. (2014). Composition and biological activities of hogweed [Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt] essential oil and its main components octyl acetate and octyl butyrate. Natural Product Research, 28(17), 1354-63. https://doi.org/10.1080/14786419.2014.904311
Maggi F, et al. Composition and Biological Activities of Hogweed [Heracleum Sphondylium L. Subsp. Ternatum (Velen.) Brummitt] Essential Oil and Its Main Components Octyl Acetate and Octyl Butyrate. Nat Prod Res. 2014;28(17):1354-63. PubMed PMID: 24697288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition and biological activities of hogweed [Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt] essential oil and its main components octyl acetate and octyl butyrate. AU - Maggi,Filippo, AU - Quassinti,Luana, AU - Bramucci,Massimo, AU - Lupidi,Giulio, AU - Petrelli,Dezemona, AU - Vitali,Luca A, AU - Papa,Fabrizio, AU - Vittori,Sauro, Y1 - 2014/04/04/ PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2014/12/17/medline KW - Apiaceae KW - Heracleum sphondylium subsp. ternatum KW - aliphatic esters KW - biological activity KW - essential oil SP - 1354 EP - 63 JF - Natural product research JO - Nat Prod Res VL - 28 IS - 17 N2 - The essential oil obtained from the fruits of hogweed (Heracleum sphondylium subsp. ternatum) growing in central Apennines (Italy) was analysed for chemical composition by gas chromatographic-flame ionisation detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The oil was composed mainly of aliphatic esters (86.9-89.5%), among them octyl acetate (54.9-60.2%) and octyl butyrate (10.1-13.4%) were the most abundant. The oil and its two major esters, octyl acetate and octyl butyrate, were tested for in vitro biological activity, namely antibacterial, antioxidant and cytotoxic, by microdilution, DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assays. Worthy of mention was only the cytotoxic activity of the oil against two tumour cell lines, i.e. A375 (human malignant melanoma) and HCT116 (human colon carcinoma) cells, with IC50 values of 48.69 and 95.83 μg/mL, respectively; the major compound responsible for this effect was octyl butyrate which displayed IC50 values of 20.19 μg/mL (100.8 μM) and 55.35 μg/mL (276.3 μM) on the same cells, respectively. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/24697288/Composition_and_biological_activities_of_hogweed_[Heracleum_sphondylium_L__subsp__ternatum__Velen___Brummitt]_essential_oil_and_its_main_components_octyl_acetate_and_octyl_butyrate_ DB - PRIME DP - Unbound Medicine ER -