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Extramedullary acute leukemia developing in a pre-existing osteoma cutis.
J Cutan Pathol. 2014 Jul; 41(7):606-11.JC

Abstract

Primary osteoma cutis (cutaneous ossification) is an uncommon disease in which there is bone formation within the skin in the absence of a demonstrable pre-existing condition. Osteoma cutis is a chronic and benign condition. We report a case of a 45-year-old man who developed extramedullary acute leukemia with a myeloid immunophenotype (myeloid sarcoma) with its initial presentation within an isolated pre-existing osteoma cutis in the post-auricular scalp without evidence of systemic acute leukemia or chronic myeloid stem cell disorders. The tumor was surgically excised without complications. Four months later, acute leukemia recurred in the contralateral posterior mandible and showed an immunophenotype consistent with acute lymphoblastic leukemia/lymphoma. The patient now has been treated by standard protocols for acute leukemia. The diagnosis of an extramedullary acute leukemia is challenging because of its inconsistent clinical and histopathologic presentations. Extramedullary acute leukemia developing in a pre-existing osteoma cutis is very unusual and has not been previously reported in the literature.

Authors+Show Affiliations

Clarient Pathology Services, Aliso Viejo, CA, USA.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24698478

Citation

Wang, Jian-Feng, and Dennis P. O'Malley. "Extramedullary Acute Leukemia Developing in a Pre-existing Osteoma Cutis." Journal of Cutaneous Pathology, vol. 41, no. 7, 2014, pp. 606-11.
Wang JF, O'Malley DP. Extramedullary acute leukemia developing in a pre-existing osteoma cutis. J Cutan Pathol. 2014;41(7):606-11.
Wang, J. F., & O'Malley, D. P. (2014). Extramedullary acute leukemia developing in a pre-existing osteoma cutis. Journal of Cutaneous Pathology, 41(7), 606-11. https://doi.org/10.1111/cup.12335
Wang JF, O'Malley DP. Extramedullary Acute Leukemia Developing in a Pre-existing Osteoma Cutis. J Cutan Pathol. 2014;41(7):606-11. PubMed PMID: 24698478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extramedullary acute leukemia developing in a pre-existing osteoma cutis. AU - Wang,Jian-Feng, AU - O'Malley,Dennis P, Y1 - 2014/04/02/ PY - 2012/10/11/received PY - 2014/02/26/revised PY - 2013/04/27/accepted PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2015/2/13/medline KW - extramedullary acute leukemia KW - hematopoietic niche KW - myeloid sarcoma KW - osteoma cutis SP - 606 EP - 11 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 41 IS - 7 N2 - Primary osteoma cutis (cutaneous ossification) is an uncommon disease in which there is bone formation within the skin in the absence of a demonstrable pre-existing condition. Osteoma cutis is a chronic and benign condition. We report a case of a 45-year-old man who developed extramedullary acute leukemia with a myeloid immunophenotype (myeloid sarcoma) with its initial presentation within an isolated pre-existing osteoma cutis in the post-auricular scalp without evidence of systemic acute leukemia or chronic myeloid stem cell disorders. The tumor was surgically excised without complications. Four months later, acute leukemia recurred in the contralateral posterior mandible and showed an immunophenotype consistent with acute lymphoblastic leukemia/lymphoma. The patient now has been treated by standard protocols for acute leukemia. The diagnosis of an extramedullary acute leukemia is challenging because of its inconsistent clinical and histopathologic presentations. Extramedullary acute leukemia developing in a pre-existing osteoma cutis is very unusual and has not been previously reported in the literature. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/24698478/Extramedullary_acute_leukemia_developing_in_a_pre_existing_osteoma_cutis_ L2 - https://doi.org/10.1111/cup.12335 DB - PRIME DP - Unbound Medicine ER -