Tags

Type your tag names separated by a space and hit enter

Human schistosomiasis.
Lancet. 2014 Jun 28; 383(9936):2253-64.Lct

Abstract

Human schistosomiasis--or bilharzia--is a parasitic disease caused by trematode flukes of the genus Schistosoma. By conservative estimates, at least 230 million people worldwide are infected with Schistosoma spp. Adult schistosome worms colonise human blood vessels for years, successfully evading the immune system while excreting hundreds to thousands of eggs daily, which must either leave the body in excreta or become trapped in nearby tissues. Trapped eggs induce a distinct immune-mediated granulomatous response that causes local and systemic pathological effects ranging from anaemia, growth stunting, impaired cognition, and decreased physical fitness, to organ-specific effects such as severe hepatosplenism, periportal fibrosis with portal hypertension, and urogenital inflammation and scarring. At present, preventive public health measures in endemic regions consist of treatment once every 1 or 2 years with the isoquinolinone drug, praziquantel, to suppress morbidity. In some locations, elimination of transmission is now the goal; however, more sensitive diagnostics are needed in both the field and clinics, and integrated environmental and health-care management will be needed to ensure elimination.

Authors+Show Affiliations

Center for Tropical and Emerging Global Disease & Department of Microbiology, University of Georgia, Athens, GA, USA. Electronic address: dcolley@uga.edu.Liverpool School of Tropical Medicine, Department of Parasitology, Liverpool, UK.Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24698483

Citation

Colley, Daniel G., et al. "Human Schistosomiasis." Lancet (London, England), vol. 383, no. 9936, 2014, pp. 2253-64.
Colley DG, Bustinduy AL, Secor WE, et al. Human schistosomiasis. Lancet. 2014;383(9936):2253-64.
Colley, D. G., Bustinduy, A. L., Secor, W. E., & King, C. H. (2014). Human schistosomiasis. Lancet (London, England), 383(9936), 2253-64. https://doi.org/10.1016/S0140-6736(13)61949-2
Colley DG, et al. Human Schistosomiasis. Lancet. 2014 Jun 28;383(9936):2253-64. PubMed PMID: 24698483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human schistosomiasis. AU - Colley,Daniel G, AU - Bustinduy,Amaya L, AU - Secor,W Evan, AU - King,Charles H, Y1 - 2014/04/01/ PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2014/7/10/medline SP - 2253 EP - 64 JF - Lancet (London, England) JO - Lancet VL - 383 IS - 9936 N2 - Human schistosomiasis--or bilharzia--is a parasitic disease caused by trematode flukes of the genus Schistosoma. By conservative estimates, at least 230 million people worldwide are infected with Schistosoma spp. Adult schistosome worms colonise human blood vessels for years, successfully evading the immune system while excreting hundreds to thousands of eggs daily, which must either leave the body in excreta or become trapped in nearby tissues. Trapped eggs induce a distinct immune-mediated granulomatous response that causes local and systemic pathological effects ranging from anaemia, growth stunting, impaired cognition, and decreased physical fitness, to organ-specific effects such as severe hepatosplenism, periportal fibrosis with portal hypertension, and urogenital inflammation and scarring. At present, preventive public health measures in endemic regions consist of treatment once every 1 or 2 years with the isoquinolinone drug, praziquantel, to suppress morbidity. In some locations, elimination of transmission is now the goal; however, more sensitive diagnostics are needed in both the field and clinics, and integrated environmental and health-care management will be needed to ensure elimination. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/24698483/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(13)61949-2 DB - PRIME DP - Unbound Medicine ER -