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Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies.

Abstract

BACKGROUND

Atopic Dermatitis (AD) has an increasing incidence and the real cause of the disease is not known yet. Probiotics may be involved in AD prevention, but their role is controversial.

OBJECTIVE

The purpose of our study was to evaluate the role of probiotics in AD occurrence.

METHODS

We carried out an extensive search on this topic in the international databases (Pubmed, Scopus,Web of knowledge, EBSCO, ARTO, Google Scholar, ClinicalTrials.gov.) selecting only those studies where the role of probiotics in AD occurrence was analysed. For the selected studies we calculated odds ratio (OR) and 95% confidence interval (CIs).

RESULTS

Initially, we found 1513 articles, of which only 26 studies fulfilled our criteria. After exclusion of studies on the same populations, 16 studies were included in the final analysis. The meta-analysis of these studies revealed that probiotics administration confers protection against AD occurrence (OR = 0.64, P < 0.001). The subgroup meta-analysis, in general population and population at high risk for allergies, suggested that probiotics administration is protective for AD development in both subgroups (OR = 0.53, P = 0.005; OR = 0.66, P < 0.001). Additional subgroup analysis showed that probiotics prenatal administration followed by postnatal administration was protective (OR = 0.61, P < 0.001) unlike only administration in postnatal period (OR = 0.95, P < 0.82). Finally, the subgroup analysis based on the type of treatment suggested that both Lactobacillus alone and Lactobacillus with Bifidobacterium are protective against AD (OR = 0.70, P = 0.004; OR = 0.62, P < 0.001).

CONCLUSION

Probiotics seem to have a protective role in AD prevention if there are administration in pre and postnatal period in both general and allergic risk population.

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  • Authors+Show Affiliations

    ,

    2nd Dermatology Chair, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy of Bucharest, Bucharest, Romania.

    , ,

    Source

    MeSH

    Bifidobacterium
    Dermatitis, Atopic
    Humans
    Infant
    Infant, Newborn
    Lactobacillus
    Primary Prevention
    Probiotics

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24698503

    Citation

    Panduru, M, et al. "Probiotics and Primary Prevention of Atopic Dermatitis: a Meta-analysis of Randomized Controlled Studies." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 29, no. 2, 2015, pp. 232-42.
    Panduru M, Panduru NM, Sălăvăstru CM, et al. Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies. J Eur Acad Dermatol Venereol. 2015;29(2):232-42.
    Panduru, M., Panduru, N. M., Sălăvăstru, C. M., & Tiplica, G. S. (2015). Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies. Journal of the European Academy of Dermatology and Venereology : JEADV, 29(2), pp. 232-42. doi:10.1111/jdv.12496.
    Panduru M, et al. Probiotics and Primary Prevention of Atopic Dermatitis: a Meta-analysis of Randomized Controlled Studies. J Eur Acad Dermatol Venereol. 2015;29(2):232-42. PubMed PMID: 24698503.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies. AU - Panduru,M, AU - Panduru,N M, AU - Sălăvăstru,C M, AU - Tiplica,G-S, Y1 - 2014/04/04/ PY - 2013/10/19/received PY - 2014/03/03/accepted PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2015/10/16/medline SP - 232 EP - 42 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 29 IS - 2 N2 - BACKGROUND: Atopic Dermatitis (AD) has an increasing incidence and the real cause of the disease is not known yet. Probiotics may be involved in AD prevention, but their role is controversial. OBJECTIVE: The purpose of our study was to evaluate the role of probiotics in AD occurrence. METHODS: We carried out an extensive search on this topic in the international databases (Pubmed, Scopus,Web of knowledge, EBSCO, ARTO, Google Scholar, ClinicalTrials.gov.) selecting only those studies where the role of probiotics in AD occurrence was analysed. For the selected studies we calculated odds ratio (OR) and 95% confidence interval (CIs). RESULTS: Initially, we found 1513 articles, of which only 26 studies fulfilled our criteria. After exclusion of studies on the same populations, 16 studies were included in the final analysis. The meta-analysis of these studies revealed that probiotics administration confers protection against AD occurrence (OR = 0.64, P < 0.001). The subgroup meta-analysis, in general population and population at high risk for allergies, suggested that probiotics administration is protective for AD development in both subgroups (OR = 0.53, P = 0.005; OR = 0.66, P < 0.001). Additional subgroup analysis showed that probiotics prenatal administration followed by postnatal administration was protective (OR = 0.61, P < 0.001) unlike only administration in postnatal period (OR = 0.95, P < 0.82). Finally, the subgroup analysis based on the type of treatment suggested that both Lactobacillus alone and Lactobacillus with Bifidobacterium are protective against AD (OR = 0.70, P = 0.004; OR = 0.62, P < 0.001). CONCLUSION: Probiotics seem to have a protective role in AD prevention if there are administration in pre and postnatal period in both general and allergic risk population. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/24698503/full_citation L2 - https://doi.org/10.1111/jdv.12496 DB - PRIME DP - Unbound Medicine ER -