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Generalized basaloid follicular hamartoma syndrome: a case report and review of the literature.
Am J Dermatopathol. 2015 Mar; 37(3):e37-40.AJ

Abstract

Basaloid follicular hamartoma (BFH) is a rare, generally benign lesion of importance because of its clinical and histopathological similarity to infundibulocystic basal cell carcinoma. Autosomal dominant generalized BFH syndrome is 1 of the 5 clinical forms of BFH that has been described in the literature. We report a case of BFH syndrome in a 47-year-old Hispanic female who presented with an increasing number of small 1- to 2-mm tan to brown smooth facial papules, few palmar pits, and cobblestoning of the tongue. Her mother had similar lesions on her face. A biopsy of one of the patient's facial lesions confirmed the diagnosis of BFH. Of note, this patient later presented with rapid growth of one of her facial lesions, and a subsequent biopsy confirmed the development of a basal cell carcinoma arising within one of her BFH lesions. Although BFH is classically stable for years and does not require immediate surgical removal, our case highlights the importance of continual monitoring of these patients, given the potential for malignant transformation of these lesions.

Authors+Show Affiliations

*Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ; †Department of Dermatology, Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ‡Department of Medicine-Division of Dermatology, UC San Diego, San Diego, CA; §Department of Dermatology, UC Irvine, Irvine, CA; ¶RBGB Dermatology, Santa Ana, CA; and ‖Laguna Pathology Medical Group, Laguna Beach, CA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

24698936

Citation

Gumaste, Priyanka, et al. "Generalized Basaloid Follicular Hamartoma Syndrome: a Case Report and Review of the Literature." The American Journal of Dermatopathology, vol. 37, no. 3, 2015, pp. e37-40.
Gumaste P, Ortiz AE, Patel A, et al. Generalized basaloid follicular hamartoma syndrome: a case report and review of the literature. Am J Dermatopathol. 2015;37(3):e37-40.
Gumaste, P., Ortiz, A. E., Patel, A., Baron, J., Harris, R., & Barr, R. (2015). Generalized basaloid follicular hamartoma syndrome: a case report and review of the literature. The American Journal of Dermatopathology, 37(3), e37-40. https://doi.org/10.1097/DAD.0000000000000085
Gumaste P, et al. Generalized Basaloid Follicular Hamartoma Syndrome: a Case Report and Review of the Literature. Am J Dermatopathol. 2015;37(3):e37-40. PubMed PMID: 24698936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Generalized basaloid follicular hamartoma syndrome: a case report and review of the literature. AU - Gumaste,Priyanka, AU - Ortiz,Arisa E, AU - Patel,Amit, AU - Baron,Jonathan, AU - Harris,Ronald, AU - Barr,Ronald, PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2015/9/1/medline SP - e37 EP - 40 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 37 IS - 3 N2 - Basaloid follicular hamartoma (BFH) is a rare, generally benign lesion of importance because of its clinical and histopathological similarity to infundibulocystic basal cell carcinoma. Autosomal dominant generalized BFH syndrome is 1 of the 5 clinical forms of BFH that has been described in the literature. We report a case of BFH syndrome in a 47-year-old Hispanic female who presented with an increasing number of small 1- to 2-mm tan to brown smooth facial papules, few palmar pits, and cobblestoning of the tongue. Her mother had similar lesions on her face. A biopsy of one of the patient's facial lesions confirmed the diagnosis of BFH. Of note, this patient later presented with rapid growth of one of her facial lesions, and a subsequent biopsy confirmed the development of a basal cell carcinoma arising within one of her BFH lesions. Although BFH is classically stable for years and does not require immediate surgical removal, our case highlights the importance of continual monitoring of these patients, given the potential for malignant transformation of these lesions. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/24698936/Generalized_basaloid_follicular_hamartoma_syndrome:_a_case_report_and_review_of_the_literature_ L2 - http://dx.doi.org/10.1097/DAD.0000000000000085 DB - PRIME DP - Unbound Medicine ER -