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Association of influenza vaccination and reduced risk of stroke hospitalization among the elderly: a population-based case-control study.
Int J Environ Res Public Health. 2014 Apr 02; 11(4):3639-49.IJ

Abstract

The aim of this study was to investigate the effect of influenza vaccination (and annual revaccination) on the risk of stroke admissions. We conducted a population-based case-control study in Taiwan. Cases consisted of patients >65 years of age who had a first-time diagnosis of stroke during the influenza seasons from 2006 to 2009. Controls were selected by matching age, sex, and index date to cases. Multiple logistic regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Ever vaccinated individuals in the current vaccination season were associated with a reduced risk of ischemic stroke admissions (OR = 0.76, 95% CI = 0.60-0.97). Compared with individuals never vaccinated against influenza during the past 5 years, the adjusted ORs were 0.92 (95% CI = 0.68-1.23) for the group with 1 or 2 vaccinations, 0.73 (95% CI = 0.54-1.00) for the group with 3 or 4 vaccinations, and 0.56 (95% CI = 0.38-0.83) for the group with 5 vaccinations. There was a significant trend of decreasing risk of ischemic stroke admissions with an increasing number of vaccinations. This study provides evidence that vaccination against influenza may reduce the risk of hospitalization for ischemic stroke and that annual revaccination provides greater protection.

Authors+Show Affiliations

Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan. lhuichen@cdc.gov.tw.Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chiu358@yahoo.com.tw.Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan. u9391006@kmu.edu.tw.Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chunyuh@kmu.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24699027

Citation

Lin, Hui-Chen, et al. "Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization Among the Elderly: a Population-based Case-control Study." International Journal of Environmental Research and Public Health, vol. 11, no. 4, 2014, pp. 3639-49.
Lin HC, Chiu HF, Ho SC, et al. Association of influenza vaccination and reduced risk of stroke hospitalization among the elderly: a population-based case-control study. Int J Environ Res Public Health. 2014;11(4):3639-49.
Lin, H. C., Chiu, H. F., Ho, S. C., & Yang, C. Y. (2014). Association of influenza vaccination and reduced risk of stroke hospitalization among the elderly: a population-based case-control study. International Journal of Environmental Research and Public Health, 11(4), 3639-49. https://doi.org/10.3390/ijerph110403639
Lin HC, et al. Association of Influenza Vaccination and Reduced Risk of Stroke Hospitalization Among the Elderly: a Population-based Case-control Study. Int J Environ Res Public Health. 2014 Apr 2;11(4):3639-49. PubMed PMID: 24699027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of influenza vaccination and reduced risk of stroke hospitalization among the elderly: a population-based case-control study. AU - Lin,Hui-Chen, AU - Chiu,Hui-Fen, AU - Ho,Shu-Chen, AU - Yang,Chun-Yuh, Y1 - 2014/04/02/ PY - 2014/01/24/received PY - 2014/03/13/revised PY - 2014/03/19/accepted PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2014/11/19/medline SP - 3639 EP - 49 JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 11 IS - 4 N2 - The aim of this study was to investigate the effect of influenza vaccination (and annual revaccination) on the risk of stroke admissions. We conducted a population-based case-control study in Taiwan. Cases consisted of patients >65 years of age who had a first-time diagnosis of stroke during the influenza seasons from 2006 to 2009. Controls were selected by matching age, sex, and index date to cases. Multiple logistic regression analysis was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Ever vaccinated individuals in the current vaccination season were associated with a reduced risk of ischemic stroke admissions (OR = 0.76, 95% CI = 0.60-0.97). Compared with individuals never vaccinated against influenza during the past 5 years, the adjusted ORs were 0.92 (95% CI = 0.68-1.23) for the group with 1 or 2 vaccinations, 0.73 (95% CI = 0.54-1.00) for the group with 3 or 4 vaccinations, and 0.56 (95% CI = 0.38-0.83) for the group with 5 vaccinations. There was a significant trend of decreasing risk of ischemic stroke admissions with an increasing number of vaccinations. This study provides evidence that vaccination against influenza may reduce the risk of hospitalization for ischemic stroke and that annual revaccination provides greater protection. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/24699027/Association_of_influenza_vaccination_and_reduced_risk_of_stroke_hospitalization_among_the_elderly:_a_population_based_case_control_study_ L2 - http://www.mdpi.com/resolver?pii=ijerph110403639 DB - PRIME DP - Unbound Medicine ER -