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Thromboembolic complications of endovenous thermal ablation and foam sclerotherapy in the treatment of great saphenous vein insufficiency.
Phlebology. 2015 Jun; 30(5):357-64.P

Abstract

OBJECTIVE

We assessed the incidence of venous thromboembolism following treatment of great saphenous insufficiency by endovenous thermal ablation or foam sclerotherapy using meta-analysis of published randomized controlled trials and case series.

METHODS

Medline, Embase, Cochrane, and Clinical Trials Registry databases were searched from January 2000 through January 2013 for randomized controlled trials and large case series employing endovenous thermal ablation or foam sclerotherapy as a single modality for the treatment of great saphenous insufficiency, with concomitant postoperative duplex scanning. Pooled (stratified) incidence of venous thromboembolism with 95% confidence intervals was estimated using the DerSimonian–Laird procedure for random effects meta-analysis. A bootstrap analysis was performed to examine between-modality differences.

RESULTS

Twelve randomized controlled trials and 19 case series investigating endovenous thermal ablation (radio frequency ablation with VNUS/Covidien ClosureFAST™ catheter only, endovenous laser ablation, or both) were included. Data from 12 randomized controlled trials and 6 case series investigating nonproprietary foam preparations were analyzed. Estimated incidence of venous thromboembolism was low (mostly <1%) and similar across treatment modalities and study types.

CONCLUSIONS

Treatment of great saphenous insufficiency by endovenous thermal ablation or foam sclerotherapy is a common vascular intervention. The stratified incidence of venous thromboembolism appears to be low as reported in both randomized controlled trials and case series investigating these modalities. Although duplex scans were obtained postoperatively, a minority of studies specified protocols for venous thromboembolism detection.

Authors+Show Affiliations

Cardiovascular Center, Tufts Medical Center, USA meghandermody@gmail.com.Lafayette Regional Vein and Laser Center, IN, USA.Cardiovascular Center, Tufts Medical Center, USA.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24699720

Citation

Dermody, Meghan, et al. "Thromboembolic Complications of Endovenous Thermal Ablation and Foam Sclerotherapy in the Treatment of Great Saphenous Vein Insufficiency." Phlebology, vol. 30, no. 5, 2015, pp. 357-64.
Dermody M, Schul MW, O'Donnell TF. Thromboembolic complications of endovenous thermal ablation and foam sclerotherapy in the treatment of great saphenous vein insufficiency. Phlebology. 2015;30(5):357-64.
Dermody, M., Schul, M. W., & O'Donnell, T. F. (2015). Thromboembolic complications of endovenous thermal ablation and foam sclerotherapy in the treatment of great saphenous vein insufficiency. Phlebology, 30(5), 357-64. https://doi.org/10.1177/0268355514529948
Dermody M, Schul MW, O'Donnell TF. Thromboembolic Complications of Endovenous Thermal Ablation and Foam Sclerotherapy in the Treatment of Great Saphenous Vein Insufficiency. Phlebology. 2015;30(5):357-64. PubMed PMID: 24699720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thromboembolic complications of endovenous thermal ablation and foam sclerotherapy in the treatment of great saphenous vein insufficiency. AU - Dermody,Meghan, AU - Schul,Marlin W, AU - O'Donnell,Thomas F, Y1 - 2014/04/03/ PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2016/2/18/medline KW - Venous thromboembolism KW - endovenous laser KW - endovenous thermal ablation KW - foam sclerotherapy KW - radiofrequency ablation KW - treatment SP - 357 EP - 64 JF - Phlebology JO - Phlebology VL - 30 IS - 5 N2 - OBJECTIVE: We assessed the incidence of venous thromboembolism following treatment of great saphenous insufficiency by endovenous thermal ablation or foam sclerotherapy using meta-analysis of published randomized controlled trials and case series. METHODS: Medline, Embase, Cochrane, and Clinical Trials Registry databases were searched from January 2000 through January 2013 for randomized controlled trials and large case series employing endovenous thermal ablation or foam sclerotherapy as a single modality for the treatment of great saphenous insufficiency, with concomitant postoperative duplex scanning. Pooled (stratified) incidence of venous thromboembolism with 95% confidence intervals was estimated using the DerSimonian–Laird procedure for random effects meta-analysis. A bootstrap analysis was performed to examine between-modality differences. RESULTS: Twelve randomized controlled trials and 19 case series investigating endovenous thermal ablation (radio frequency ablation with VNUS/Covidien ClosureFAST™ catheter only, endovenous laser ablation, or both) were included. Data from 12 randomized controlled trials and 6 case series investigating nonproprietary foam preparations were analyzed. Estimated incidence of venous thromboembolism was low (mostly <1%) and similar across treatment modalities and study types. CONCLUSIONS: Treatment of great saphenous insufficiency by endovenous thermal ablation or foam sclerotherapy is a common vascular intervention. The stratified incidence of venous thromboembolism appears to be low as reported in both randomized controlled trials and case series investigating these modalities. Although duplex scans were obtained postoperatively, a minority of studies specified protocols for venous thromboembolism detection. SN - 1758-1125 UR - https://www.unboundmedicine.com/medline/citation/24699720/Thromboembolic_complications_of_endovenous_thermal_ablation_and_foam_sclerotherapy_in_the_treatment_of_great_saphenous_vein_insufficiency_ L2 - https://journals.sagepub.com/doi/10.1177/0268355514529948?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -