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Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium.
Int J Cancer. 2014 Nov 01; 135(9):2157-72.IJ

Abstract

Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms.

Authors+Show Affiliations

International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24700406

Citation

Bailey, Helen D., et al. "Parental Occupational Pesticide Exposure and the Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International Consortium." International Journal of Cancer, vol. 135, no. 9, 2014, pp. 2157-72.
Bailey HD, Fritschi L, Infante-Rivard C, et al. Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. Int J Cancer. 2014;135(9):2157-72.
Bailey, H. D., Fritschi, L., Infante-Rivard, C., Glass, D. C., Miligi, L., Dockerty, J. D., Lightfoot, T., Clavel, J., Roman, E., Spector, L. G., Kaatsch, P., Metayer, C., Magnani, C., Milne, E., Polychronopoulou, S., Simpson, J., Rudant, J., Sidi, V., Rondelli, R., ... Schüz, J. (2014). Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. International Journal of Cancer, 135(9), 2157-72. https://doi.org/10.1002/ijc.28854
Bailey HD, et al. Parental Occupational Pesticide Exposure and the Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International Consortium. Int J Cancer. 2014 Nov 1;135(9):2157-72. PubMed PMID: 24700406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. AU - Bailey,Helen D, AU - Fritschi,Lin, AU - Infante-Rivard,Claire, AU - Glass,Deborah C, AU - Miligi,Lucia, AU - Dockerty,John D, AU - Lightfoot,Tracy, AU - Clavel,Jacqueline, AU - Roman,Eve, AU - Spector,Logan G, AU - Kaatsch,Peter, AU - Metayer,Catherine, AU - Magnani,Corrado, AU - Milne,Elizabeth, AU - Polychronopoulou,Sophia, AU - Simpson,Jill, AU - Rudant,Jérémie, AU - Sidi,Vasiliki, AU - Rondelli,Roberto, AU - Orsi,Laurent, AU - Kang,Alice Y, AU - Petridou,Eleni, AU - Schüz,Joachim, Y1 - 2014/04/04/ PY - 2013/12/24/received PY - 2014/02/26/accepted PY - 2014/4/5/entrez PY - 2014/4/5/pubmed PY - 2014/10/22/medline KW - childhood KW - leukemia KW - meta-analysis KW - occupation KW - pesticide KW - pooled analysis SP - 2157 EP - 72 JF - International journal of cancer JO - Int J Cancer VL - 135 IS - 9 N2 - Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/24700406/Parental_occupational_pesticide_exposure_and_the_risk_of_childhood_leukemia_in_the_offspring:_findings_from_the_childhood_leukemia_international_consortium_ L2 - https://doi.org/10.1002/ijc.28854 DB - PRIME DP - Unbound Medicine ER -