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Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration.
J Refract Surg. 2014 Apr; 30(4):272-6.JR

Abstract

PURPOSE

To present the results after simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking for pellucid marginal corneal degeneration.

METHODS

In this prospective, interventional case series, 6 patients (8 eyes) with pellucid marginal corneal degeneration were enrolled. All patients underwent simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking; corneal epithelium was removed by transepithelial phototherapeutic keratectomy during treatment (Cretan protocol plus conventional photorefractive keratectomy). Visual and refractive outcomes were evaluated along with endothelial cell density preoperatively and at 1, 3, 6, and 12 months postoperatively.

RESULTS

No intraoperative or postoperative complications were observed in any of the patients. LogMAR mean uncorrected distance visual acuity improved significantly from 1.05 ± 0.33 preoperatively to 0.41 ± 0.27 (P = .018) at 12 months postoperatively. Mean corrected distance visual acuity did not change significantly (P > .05) postoperatively. Mean spherical equivalent improved significantly from -3.52 ± 2.29 diopters preoperatively to -1.57 ± 1.76 diopters (P = .028) at last follow-up. Mean corneal astigmatism was significantly reduced from -6.83 ± 2.33 diopters preoperatively to -4.71 ± 1.89 diopters (P = .018) at the last follow-up. No endothelial cell density alterations were observed throughout the follow-up period (P > .05).

CONCLUSIONS

Simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking seems to be an effective, safe, and promising treatment for the management of pellucid marginal corneal degeneration.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24702579

Citation

Kymionis, George D., et al. "Simultaneous Conventional Photorefractive Keratectomy and Corneal Collagen Cross-linking for Pellucid Marginal Corneal Degeneration." Journal of Refractive Surgery (Thorofare, N.J. : 1995), vol. 30, no. 4, 2014, pp. 272-6.
Kymionis GD, Grentzelos MA, Plaka AD, et al. Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration. J Refract Surg. 2014;30(4):272-6.
Kymionis, G. D., Grentzelos, M. A., Plaka, A. D., Tsoulnaras, K. I., Kankariya, V. P., Shehadeh, M. M., & Pallikaris, I. G. (2014). Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration. Journal of Refractive Surgery (Thorofare, N.J. : 1995), 30(4), 272-6. https://doi.org/10.3928/1081597X-20140320-06
Kymionis GD, et al. Simultaneous Conventional Photorefractive Keratectomy and Corneal Collagen Cross-linking for Pellucid Marginal Corneal Degeneration. J Refract Surg. 2014;30(4):272-6. PubMed PMID: 24702579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration. AU - Kymionis,George D, AU - Grentzelos,Michael A, AU - Plaka,Argyro D, AU - Tsoulnaras,Konstantinos I, AU - Kankariya,Vardhaman P, AU - Shehadeh,Mohammad M, AU - Pallikaris,Ioannis G, PY - 2013/11/18/received PY - 2014/01/02/accepted PY - 2014/4/8/entrez PY - 2014/4/8/pubmed PY - 2014/5/16/medline SP - 272 EP - 6 JF - Journal of refractive surgery (Thorofare, N.J. : 1995) JO - J Refract Surg VL - 30 IS - 4 N2 - PURPOSE: To present the results after simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking for pellucid marginal corneal degeneration. METHODS: In this prospective, interventional case series, 6 patients (8 eyes) with pellucid marginal corneal degeneration were enrolled. All patients underwent simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking; corneal epithelium was removed by transepithelial phototherapeutic keratectomy during treatment (Cretan protocol plus conventional photorefractive keratectomy). Visual and refractive outcomes were evaluated along with endothelial cell density preoperatively and at 1, 3, 6, and 12 months postoperatively. RESULTS: No intraoperative or postoperative complications were observed in any of the patients. LogMAR mean uncorrected distance visual acuity improved significantly from 1.05 ± 0.33 preoperatively to 0.41 ± 0.27 (P = .018) at 12 months postoperatively. Mean corrected distance visual acuity did not change significantly (P > .05) postoperatively. Mean spherical equivalent improved significantly from -3.52 ± 2.29 diopters preoperatively to -1.57 ± 1.76 diopters (P = .028) at last follow-up. Mean corneal astigmatism was significantly reduced from -6.83 ± 2.33 diopters preoperatively to -4.71 ± 1.89 diopters (P = .018) at the last follow-up. No endothelial cell density alterations were observed throughout the follow-up period (P > .05). CONCLUSIONS: Simultaneous conventional photorefractive keratectomy combined with corneal collagen cross-linking seems to be an effective, safe, and promising treatment for the management of pellucid marginal corneal degeneration. SN - 1081-597X UR - https://www.unboundmedicine.com/medline/citation/24702579/Simultaneous_conventional_photorefractive_keratectomy_and_corneal_collagen_cross_linking_for_pellucid_marginal_corneal_degeneration_ L2 - https://www.healio.com/doiresolver?doi=10.3928/1081597X-20140320-06 DB - PRIME DP - Unbound Medicine ER -