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Chemical investigation of the roots of Polygala sibirica L.
Chin J Nat Med. 2014 Mar; 12(3):225-8.CJ

Abstract

AIM

To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae)

METHOD

The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.

RESULTS

A total of sixteen compounds, including five xanthones (5, 7-10), five saccharide esters (1, 3, 4, 12, 13), two flavonoids (14, 16), two triterpenoids (11, 15), one phenylpropanoid (6), and one benzophenone glycoside (2) were isolated. Their structures were determined as sibiricose A7 (1), sibiriphenone A (2), polygalatenoside A (3), polygalatenoside C (4), lancerin (5), 3, 4, 5-trimethoxycinnamic acid (6), 6-hydroxy-1, 2, 3, 7-tetramethoxyxanthone (7), 1, 3, 7-trihydroxy-2-methoxyxanthone (8), onjixanthone II (9), 1, 2, 3, 6, 7-pentamethoxyxanthone (10), presenegenin (11), 3'-O-3, 4, 5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose (12), tenuifoliside C (13), 5, 3'-dihydroxy-7, 4'-dimethoxyflavonol-3-O-β-D-glucopyranoside (14), tenuifolin (15), and rhamnetin 3-O-β-D-glucopyranoside (16).

CONCLUSION

Compounds 1 and 2 are two new compounds from P. sibirica.

Authors+Show Affiliations

State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China. Electronic address: yongjiang@bjmu.edu.cn.State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: pengfeitu@vip.163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24702811

Citation

Zhou, Yu-Hong, et al. "Chemical Investigation of the Roots of Polygala Sibirica L." Chinese Journal of Natural Medicines, vol. 12, no. 3, 2014, pp. 225-8.
Zhou YH, Zhang SY, Guo Q, et al. Chemical investigation of the roots of Polygala sibirica L. Chin J Nat Med. 2014;12(3):225-8.
Zhou, Y. H., Zhang, S. Y., Guo, Q., Chai, X. Y., Jiang, Y., & Tu, P. F. (2014). Chemical investigation of the roots of Polygala sibirica L. Chinese Journal of Natural Medicines, 12(3), 225-8. https://doi.org/10.1016/S1875-5364(14)60038-8
Zhou YH, et al. Chemical Investigation of the Roots of Polygala Sibirica L. Chin J Nat Med. 2014;12(3):225-8. PubMed PMID: 24702811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical investigation of the roots of Polygala sibirica L. AU - Zhou,Yu-Hong, AU - Zhang,Shui-Ying, AU - Guo,Qiang, AU - Chai,Xing-Yun, AU - Jiang,Yong, AU - Tu,Peng-Fei, PY - 2013/04/14/received PY - 2014/4/8/entrez PY - 2014/4/8/pubmed PY - 2014/12/15/medline KW - Polygala sibirica KW - Polygalaceae KW - Sibiricose A7 KW - Sibiriphenone A SP - 225 EP - 8 JF - Chinese journal of natural medicines JO - Chin J Nat Med VL - 12 IS - 3 N2 - AIM: To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae) METHOD: The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data. RESULTS: A total of sixteen compounds, including five xanthones (5, 7-10), five saccharide esters (1, 3, 4, 12, 13), two flavonoids (14, 16), two triterpenoids (11, 15), one phenylpropanoid (6), and one benzophenone glycoside (2) were isolated. Their structures were determined as sibiricose A7 (1), sibiriphenone A (2), polygalatenoside A (3), polygalatenoside C (4), lancerin (5), 3, 4, 5-trimethoxycinnamic acid (6), 6-hydroxy-1, 2, 3, 7-tetramethoxyxanthone (7), 1, 3, 7-trihydroxy-2-methoxyxanthone (8), onjixanthone II (9), 1, 2, 3, 6, 7-pentamethoxyxanthone (10), presenegenin (11), 3'-O-3, 4, 5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose (12), tenuifoliside C (13), 5, 3'-dihydroxy-7, 4'-dimethoxyflavonol-3-O-β-D-glucopyranoside (14), tenuifolin (15), and rhamnetin 3-O-β-D-glucopyranoside (16). CONCLUSION: Compounds 1 and 2 are two new compounds from P. sibirica. SN - 1875-5364 UR - https://www.unboundmedicine.com/medline/citation/24702811/Chemical_investigation_of_the_roots_of_Polygala_sibirica_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-5364(14)60038-8 DB - PRIME DP - Unbound Medicine ER -