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The genetic basis of gout.
Rheum Dis Clin North Am. 2014 May; 40(2):279-90.RD

Abstract

Gout results from deposition of monosodium urate (MSU) crystals. Elevated serum urate concentrations (hyperuricemia) are not sufficient for the development of disease. Genome-wide association studies (GWAS) have identified 28 loci controlling serum urate levels. The largest genetic effects are seen in genes involved in the renal excretion of uric acid, with others being involved in glycolysis. Whereas much is understood about the genetic control of serum urate levels, little is known about the genetic control of inflammatory responses to MSU crystals. Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Merriman TR
Department of Biochemistry, University of Otago, Dunedin 9012, New Zealand. Electronic address: tony.merriman@otago.ac.nz.
Choi HK
Section of Rheumatology and Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA 02118, USA.
Dalbeth N
Department of Medicine, University of Auckland, Auckland 1023, New Zealand.

MeSH

Gene-Environment InteractionGenome-Wide Association StudyGlycolysisGoutHumansHyperuricemiaKidneyUric Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24703347

Citation

Merriman, Tony R., et al. "The Genetic Basis of Gout." Rheumatic Diseases Clinics of North America, vol. 40, no. 2, 2014, pp. 279-90.
Merriman TR, Choi HK, Dalbeth N. The genetic basis of gout. Rheum Dis Clin North Am. 2014;40(2):279-90.
Merriman, T. R., Choi, H. K., & Dalbeth, N. (2014). The genetic basis of gout. Rheumatic Diseases Clinics of North America, 40(2), 279-90. https://doi.org/10.1016/j.rdc.2014.01.009
Merriman TR, Choi HK, Dalbeth N. The Genetic Basis of Gout. Rheum Dis Clin North Am. 2014;40(2):279-90. PubMed PMID: 24703347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetic basis of gout. AU - Merriman,Tony R, AU - Choi,Hyon K, AU - Dalbeth,Nicola, Y1 - 2014/02/19/ PY - 2014/4/8/entrez PY - 2014/4/8/pubmed PY - 2014/12/17/medline KW - ABCG2 KW - Association KW - Gene KW - Genome-wide association studies KW - Gout KW - SLC2A9 KW - Urate SP - 279 EP - 90 JF - Rheumatic diseases clinics of North America JO - Rheum Dis Clin North Am VL - 40 IS - 2 N2 - Gout results from deposition of monosodium urate (MSU) crystals. Elevated serum urate concentrations (hyperuricemia) are not sufficient for the development of disease. Genome-wide association studies (GWAS) have identified 28 loci controlling serum urate levels. The largest genetic effects are seen in genes involved in the renal excretion of uric acid, with others being involved in glycolysis. Whereas much is understood about the genetic control of serum urate levels, little is known about the genetic control of inflammatory responses to MSU crystals. Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS. SN - 1558-3163 UR - https://www.unboundmedicine.com/medline/citation/24703347/The_genetic_basis_of_gout_ DB - PRIME DP - Unbound Medicine ER -