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Five new prenylated chalcones from Desmodium renifolium.
Fitoterapia. 2014 Jun; 95:214-9.F

Abstract

Five unusual new prenylated chalcones, renifolins D-H (1-5), were isolated from whole Desmodium renifolium plants. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. All of the isolates were evaluated for cytotoxicity using five tumor cell lines. Compounds 2 and 3 exhibited cytotoxicity against A549 cells, with IC50 values of 2.8 and 2.2 μM, respectively.

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Authors+Show Affiliations

Li YP
School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, Yunnan, People's Republic of China.
Yang YC
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Li YK
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China.
Jiang ZY
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China.
Huang XZ
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China.
Wang WG
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Gao XM
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China. Electronic address: gao_xuemei@hotmail.com.
Hu QF
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, Yunnan, People's Republic of China. Electronic address: huqiufena@aliyun.com.

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalChalconesFabaceaeHumansInhibitory Concentration 50Magnetic Resonance SpectroscopyMolecular StructurePlant ExtractsPlants, MedicinalPrenylation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24704553

Citation

Li, Yan-Ping, et al. "Five New Prenylated Chalcones From Desmodium Renifolium." Fitoterapia, vol. 95, 2014, pp. 214-9.
Li YP, Yang YC, Li YK, et al. Five new prenylated chalcones from Desmodium renifolium. Fitoterapia. 2014;95:214-9.
Li, Y. P., Yang, Y. C., Li, Y. K., Jiang, Z. Y., Huang, X. Z., Wang, W. G., Gao, X. M., & Hu, Q. F. (2014). Five new prenylated chalcones from Desmodium renifolium. Fitoterapia, 95, 214-9. https://doi.org/10.1016/j.fitote.2014.03.026
Li YP, et al. Five New Prenylated Chalcones From Desmodium Renifolium. Fitoterapia. 2014;95:214-9. PubMed PMID: 24704553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five new prenylated chalcones from Desmodium renifolium. AU - Li,Yan-Ping, AU - Yang,Yu-Chun, AU - Li,Yin-Ke, AU - Jiang,Zhi-Yong, AU - Huang,Xiang-Zhong, AU - Wang,Wei-Guang, AU - Gao,Xue-Mei, AU - Hu,Qiu-Fen, Y1 - 2014/04/04/ PY - 2013/12/24/received PY - 2014/03/24/revised PY - 2014/03/26/accepted PY - 2014/4/8/entrez PY - 2014/4/8/pubmed PY - 2015/1/8/medline KW - 5′-Prenylbutein (PubChem CID: 11267805) KW - Antiarone J (PubChem CID: 42607617) KW - Antiarone K (PubChem CID: 42607618) KW - Cytotoxicity KW - Desmodium renifolium KW - Prenylated chalcone SP - 214 EP - 9 JF - Fitoterapia JO - Fitoterapia VL - 95 N2 - Five unusual new prenylated chalcones, renifolins D-H (1-5), were isolated from whole Desmodium renifolium plants. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. All of the isolates were evaluated for cytotoxicity using five tumor cell lines. Compounds 2 and 3 exhibited cytotoxicity against A549 cells, with IC50 values of 2.8 and 2.2 μM, respectively. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24704553/Five_new_prenylated_chalcones_from_Desmodium_renifolium_ DB - PRIME DP - Unbound Medicine ER -