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Effect of Bridelia ferruginea Benth (Euphorbiaceae) ethyl acetate and acetone fractions on insulin resistance in fructose drinking mice.
J Ethnopharmacol. 2014 May 14; 153(3):896-9.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The root of Bridelia ferruginea is traditionally used as a treatment for type 2 diabetes. The present study was investigated to evaluate the effect of Bridelia ferruginea root bark fractions on some markers of type 2 diabetes on fructose drinking mice.

MATERIALS AND METHODS

Mice received a solution of fructose 15% during 42 days ad libitum; at the 15th day to the 42nd day, they received distilled water for fructose drinking control group, metformin 50 mg/kg per day or fractions 50 mg/kg per day for treatment groups. The normal control group received only distilled water during the experiment. After 6 weeks of experiment, OGTT, fasting blood glucose, plasma insulin, triglycerides (TG), total cholesterol, AST and ALT levels were measured.

RESULTS

Fructose drinking control group (F) showed significant (p<0.001) increase of glucose tolerance, plasma levels of total cholesterol, triglycerides and insulin index for insulin resistance (Homeostasis Model Assessment ratio HOMA-IR) as compared to normal control mice. In treated groups, there was a significant reduction of glucose intolerance respectively 74% (p<0.001), 25% (p<0.5) and 92% (p<0.001) for ethyl acetate fraction, acetone fraction and metformin at the same dose of 50 mg/kg per day during 4 weeks administration. In ethyl acetate fraction and metformin treated groups, biochemical parameters and insulin index were significantly (p<0.001) lower than that of fructose drinking control group.

CONCLUSIONS

This indicates that Bridelia ferruginea root bark ethyl acetate fraction improved insulin resistance as metformin significantly in type 2 diabetes.

Authors+Show Affiliations

Department of Animal Physiology, Faculty of Sciences, University of Lome, Togo; Department of Pharmacology, University of Bordeaux Segalen, 33076 Bordeaux, France. Electronic address: bbakoma@yahoo.fr.Department of Pharmacology, University of Bordeaux Segalen, 33076 Bordeaux, France.Department of Animal Physiology, Faculty of Sciences, University of Lome, Togo.Department of Animal Physiology, Faculty of Sciences, University of Lome, Togo.Department of Animal Physiology, Faculty of Sciences, University of Lome, Togo.Department of Animal Physiology, Faculty of Sciences, University of Lome, Togo.Department of Pharmacology, University of Bordeaux Segalen, 33076 Bordeaux, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24704594

Citation

Bakoma, Batomayena, et al. "Effect of Bridelia Ferruginea Benth (Euphorbiaceae) Ethyl Acetate and Acetone Fractions On Insulin Resistance in Fructose Drinking Mice." Journal of Ethnopharmacology, vol. 153, no. 3, 2014, pp. 896-9.
Bakoma B, Berké B, Eklu-Gadegbeku K, et al. Effect of Bridelia ferruginea Benth (Euphorbiaceae) ethyl acetate and acetone fractions on insulin resistance in fructose drinking mice. J Ethnopharmacol. 2014;153(3):896-9.
Bakoma, B., Berké, B., Eklu-Gadegbeku, K., Agbonon, A., Aklikokou, K., Gbeassor, M., & Moore, N. (2014). Effect of Bridelia ferruginea Benth (Euphorbiaceae) ethyl acetate and acetone fractions on insulin resistance in fructose drinking mice. Journal of Ethnopharmacology, 153(3), 896-9. https://doi.org/10.1016/j.jep.2014.03.065
Bakoma B, et al. Effect of Bridelia Ferruginea Benth (Euphorbiaceae) Ethyl Acetate and Acetone Fractions On Insulin Resistance in Fructose Drinking Mice. J Ethnopharmacol. 2014 May 14;153(3):896-9. PubMed PMID: 24704594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Bridelia ferruginea Benth (Euphorbiaceae) ethyl acetate and acetone fractions on insulin resistance in fructose drinking mice. AU - Bakoma,Batomayena, AU - Berké,Bénédicte, AU - Eklu-Gadegbeku,Kwashie, AU - Agbonon,Amegnona, AU - Aklikokou,Kodjo, AU - Gbeassor,Messanvi, AU - Moore,Nicholas, Y1 - 2014/04/02/ PY - 2014/01/29/received PY - 2014/02/18/revised PY - 2014/03/26/accepted PY - 2014/4/8/entrez PY - 2014/4/8/pubmed PY - 2015/1/13/medline KW - Acetone (PubChem CID: 180) KW - Bridelia ferruginea KW - Chloroform (PubChem CID: 6212) KW - Diabetes KW - Dichloromethane (PubChem CID: 6344) KW - Ethanol (PubChem CID: 702) KW - Ethyl acetate (PubChem CID: 8095) KW - Fructose KW - Fructose (PubChem CID: 5984) KW - Glucose (PubChem CID: 79025) KW - Hexane (PubChem CID: 8058) KW - Insulin resistance KW - Metformin (PubChem CID: 4091) SP - 896 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 153 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The root of Bridelia ferruginea is traditionally used as a treatment for type 2 diabetes. The present study was investigated to evaluate the effect of Bridelia ferruginea root bark fractions on some markers of type 2 diabetes on fructose drinking mice. MATERIALS AND METHODS: Mice received a solution of fructose 15% during 42 days ad libitum; at the 15th day to the 42nd day, they received distilled water for fructose drinking control group, metformin 50 mg/kg per day or fractions 50 mg/kg per day for treatment groups. The normal control group received only distilled water during the experiment. After 6 weeks of experiment, OGTT, fasting blood glucose, plasma insulin, triglycerides (TG), total cholesterol, AST and ALT levels were measured. RESULTS: Fructose drinking control group (F) showed significant (p<0.001) increase of glucose tolerance, plasma levels of total cholesterol, triglycerides and insulin index for insulin resistance (Homeostasis Model Assessment ratio HOMA-IR) as compared to normal control mice. In treated groups, there was a significant reduction of glucose intolerance respectively 74% (p<0.001), 25% (p<0.5) and 92% (p<0.001) for ethyl acetate fraction, acetone fraction and metformin at the same dose of 50 mg/kg per day during 4 weeks administration. In ethyl acetate fraction and metformin treated groups, biochemical parameters and insulin index were significantly (p<0.001) lower than that of fructose drinking control group. CONCLUSIONS: This indicates that Bridelia ferruginea root bark ethyl acetate fraction improved insulin resistance as metformin significantly in type 2 diabetes. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24704594/Effect_of_Bridelia_ferruginea_Benth__Euphorbiaceae__ethyl_acetate_and_acetone_fractions_on_insulin_resistance_in_fructose_drinking_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(14)00269-4 DB - PRIME DP - Unbound Medicine ER -