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Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women.
Int J Cancer 2014; 135(10):2413-23IJ

Abstract

The association between fish, ω-3 and ω-6 polyunsaturated fatty acid (PUFA) intake and risk of colorectal cancer (CRC) remains inconclusive. Recent prospective studies suggest that the relationship may vary by gender, subsite and duration of follow-up. We followed 123,529 US adults (76,386 women and 47,143 men) without a history of cancer at baseline for 24 to 26 years. Fish and PUFA intake was assessed at baseline and updated every 4 years by using a validated food-frequency questionnaire. We found no overall association between fish, ω-3 and ω-6 PUFA intake and CRC risk with hazard ratio (HR) of 1.03 [95% confidence interval (CI): 0.89-1.20] comparing marine ω-3 intake of ≥ 0.30 g/d versus <0.15 g/d among women and 1.05 (95% CI: 0.85-1.30) comparing intake of ≥ 0.41 g/d versus <0.16 g/d among men. However, fish and marine ω-3 PUFA intake appeared to be positively associated with risk of distal colon cancer in both men and women and inversely with risk of rectal cancer in men. In an analysis based on a limited number of cases, marine ω-3 PUFA intake assessed 12-16 years before diagnosis tended to be inversely associated with CRC risk in men (HR: 0.76; 95% CI: 0.52-1.10). In conclusion, although no overall association between fish, ω-3 or ω-6 PUFA intake was observed with CRC risk, marine ω-3 PUFA may be differentially associated with risk of distal colon and rectal cancers and a long latency may be needed for its protection against CRC in men.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24706410

Citation

Song, Mingyang, et al. "Dietary Intake of Fish, Ω-3 and Ω-6 Fatty Acids and Risk of Colorectal Cancer: a Prospective Study in U.S. Men and Women." International Journal of Cancer, vol. 135, no. 10, 2014, pp. 2413-23.
Song M, Chan AT, Fuchs CS, et al. Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women. Int J Cancer. 2014;135(10):2413-23.
Song, M., Chan, A. T., Fuchs, C. S., Ogino, S., Hu, F. B., Mozaffarian, D., ... Wu, K. (2014). Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women. International Journal of Cancer, 135(10), pp. 2413-23. doi:10.1002/ijc.28878.
Song M, et al. Dietary Intake of Fish, Ω-3 and Ω-6 Fatty Acids and Risk of Colorectal Cancer: a Prospective Study in U.S. Men and Women. Int J Cancer. 2014 Nov 15;135(10):2413-23. PubMed PMID: 24706410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women. AU - Song,Mingyang, AU - Chan,Andrew T, AU - Fuchs,Charles S, AU - Ogino,Shuji, AU - Hu,Frank B, AU - Mozaffarian,Dariush, AU - Ma,Jing, AU - Willett,Walter C, AU - Giovannucci,Edward L, AU - Wu,Kana, Y1 - 2014/04/15/ PY - 2014/01/19/received PY - 2014/03/12/accepted PY - 2014/4/8/entrez PY - 2014/4/8/pubmed PY - 2014/11/19/medline KW - colorectal cancer KW - fish KW - ω-3 polyunsaturated fatty acid KW - ω-6 polyunsaturated fatty acid SP - 2413 EP - 23 JF - International journal of cancer JO - Int. J. Cancer VL - 135 IS - 10 N2 - The association between fish, ω-3 and ω-6 polyunsaturated fatty acid (PUFA) intake and risk of colorectal cancer (CRC) remains inconclusive. Recent prospective studies suggest that the relationship may vary by gender, subsite and duration of follow-up. We followed 123,529 US adults (76,386 women and 47,143 men) without a history of cancer at baseline for 24 to 26 years. Fish and PUFA intake was assessed at baseline and updated every 4 years by using a validated food-frequency questionnaire. We found no overall association between fish, ω-3 and ω-6 PUFA intake and CRC risk with hazard ratio (HR) of 1.03 [95% confidence interval (CI): 0.89-1.20] comparing marine ω-3 intake of ≥ 0.30 g/d versus <0.15 g/d among women and 1.05 (95% CI: 0.85-1.30) comparing intake of ≥ 0.41 g/d versus <0.16 g/d among men. However, fish and marine ω-3 PUFA intake appeared to be positively associated with risk of distal colon cancer in both men and women and inversely with risk of rectal cancer in men. In an analysis based on a limited number of cases, marine ω-3 PUFA intake assessed 12-16 years before diagnosis tended to be inversely associated with CRC risk in men (HR: 0.76; 95% CI: 0.52-1.10). In conclusion, although no overall association between fish, ω-3 or ω-6 PUFA intake was observed with CRC risk, marine ω-3 PUFA may be differentially associated with risk of distal colon and rectal cancers and a long latency may be needed for its protection against CRC in men. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/24706410/Dietary_intake_of_fish_ω_3_and_ω_6_fatty_acids_and_risk_of_colorectal_cancer:_A_prospective_study_in_U_S__men_and_women_ L2 - https://doi.org/10.1002/ijc.28878 DB - PRIME DP - Unbound Medicine ER -