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Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats.
J Ethnopharmacol 2014; 153(3):917-21JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Ginseng has various bioactive effects on human health including its potential activity of improving the glucose homeostasis and insulin sensitivity.

MATERIALS AND METHODS

Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract enriched with ginsenosides was used as experimental material. Streptozotocin-induced diabetic 'Sprague Dawley' male rats were used as experimental systems and were fed with Tissue culture raised mountain ginseng adventitious root extract. Field cultivated Korean ginseng root extract fed rats were used as positive control and several indices such as body weight, blood glucose level and other serological indicators were tested.

RESULTS

Chemical profile showed TCMGARs were rich in varied ginsenosides especially Rb1, Rb2, Rc, Rd, Rg3, and Rh2 when compared to field cultivated Korean ginseng. TCMGARs extract at dosage levels of 250 and 500 mg/kg body weight significantly lowered the blood glucose, total cholesterol and triglyceride content in streptozotocin-induced diabetic rats.

CONCLUSION

The data of in vivo experiments on anti-glycemic effects of TCMGARs proves their efficacy and also their use as dietary supplement.

Authors+Show Affiliations

Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea; Department of Botany, Karnatak University, Dharwad 580003, India. Electronic address: nmurthy60@yahoo.co.in.Department of Botany, Karnatak University, Dharwad 580003, India.Cheongsol Biotech Co. Ltd., Industry Academic Cooperation Foundation Agribusiness Incubator Center, 205, Chungbuk National University, Cheongju 361-763, Republic of Korea.Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea; Cheongsol Biotech Co. Ltd., Industry Academic Cooperation Foundation Agribusiness Incubator Center, 205, Chungbuk National University, Cheongju 361-763, Republic of Korea. Electronic address: paekky@chungbuk.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24709314

Citation

Murthy, Hosakatte Niranjana, et al. "Efficacy of Ginseng Adventitious Root Extract On Hyperglycemia in Streptozotocin-induced Diabetic Rats." Journal of Ethnopharmacology, vol. 153, no. 3, 2014, pp. 917-21.
Murthy HN, Dandin VS, Lee EJ, et al. Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2014;153(3):917-21.
Murthy, H. N., Dandin, V. S., Lee, E. J., & Paek, K. Y. (2014). Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 153(3), pp. 917-21. doi:10.1016/j.jep.2014.03.062.
Murthy HN, et al. Efficacy of Ginseng Adventitious Root Extract On Hyperglycemia in Streptozotocin-induced Diabetic Rats. J Ethnopharmacol. 2014 May 14;153(3):917-21. PubMed PMID: 24709314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats. AU - Murthy,Hosakatte Niranjana, AU - Dandin,Vijayalaxmi S, AU - Lee,Eun Jung, AU - Paek,Kee Yoeup, Y1 - 2014/04/05/ PY - 2013/12/21/received PY - 2014/03/23/revised PY - 2014/03/28/accepted PY - 2014/4/9/entrez PY - 2014/4/9/pubmed PY - 2015/1/13/medline KW - Antidiabetic KW - Blood glucose KW - Dietary supplement KW - Ginsenosides SP - 917 EP - 21 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 153 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng has various bioactive effects on human health including its potential activity of improving the glucose homeostasis and insulin sensitivity. MATERIALS AND METHODS: Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract enriched with ginsenosides was used as experimental material. Streptozotocin-induced diabetic 'Sprague Dawley' male rats were used as experimental systems and were fed with Tissue culture raised mountain ginseng adventitious root extract. Field cultivated Korean ginseng root extract fed rats were used as positive control and several indices such as body weight, blood glucose level and other serological indicators were tested. RESULTS: Chemical profile showed TCMGARs were rich in varied ginsenosides especially Rb1, Rb2, Rc, Rd, Rg3, and Rh2 when compared to field cultivated Korean ginseng. TCMGARs extract at dosage levels of 250 and 500 mg/kg body weight significantly lowered the blood glucose, total cholesterol and triglyceride content in streptozotocin-induced diabetic rats. CONCLUSION: The data of in vivo experiments on anti-glycemic effects of TCMGARs proves their efficacy and also their use as dietary supplement. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24709314/Efficacy_of_ginseng_adventitious_root_extract_on_hyperglycemia_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(14)00266-9 DB - PRIME DP - Unbound Medicine ER -