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Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury.
Exp Eye Res. 2014 May; 122:110-8.EE

Abstract

The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg. At 7 days after ischemia, retinal damage was evaluated by measuring the retinal thickness and the number of retinal ganglion cells. Western blot was used to measure changes in the (pro)renin receptor expression. Retinal mRNA expressions of prorenin, angiotensinogen and angiotensin II type 1 receptor (AT1-R) were measured by real-time polymerase chain reaction. Rats were treated with the renin inhibitor, aliskiren. Although the number of retinal ganglion cells and the inner retinal thickness were significantly decreased at 7 days after ischemia, treatment with aliskiren significantly inhibited retinal ischemic injury. Administration of aliskiren increased mRNA expression of prorenin in the retina at 3 h after the reperfusion. The expression of the (pro)renin receptor was not changed after ischemia-reperfusion injury with or without aliskiren. Although there was an increase in the retinal expression of AT1-R at 3 h after the reperfusion, aliskiren administration suppressed this expression. A renin inhibitor attenuated subsequent ischemic damage in the rat retina via the inhibition of the prorenin-induced angiotensin generation.

Authors+Show Affiliations

Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan. Electronic address: kazuyk@med.kagawa-u.ac.jp.Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Neurobiology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Neurobiology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Pharmacology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan.Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan; Department of Ophthalmology, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24709336

Citation

Tenkumo, Kaori, et al. "Effect of the Renin Inhibitor Aliskiren Against Retinal Ischemia-reperfusion Injury." Experimental Eye Research, vol. 122, 2014, pp. 110-8.
Tenkumo K, Hirooka K, Sherajee SJ, et al. Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury. Exp Eye Res. 2014;122:110-8.
Tenkumo, K., Hirooka, K., Sherajee, S. J., Nakamura, T., Itano, T., Nitta, E., Fujita, T., Nishiyama, A., & Shiraga, F. (2014). Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury. Experimental Eye Research, 122, 110-8. https://doi.org/10.1016/j.exer.2014.03.011
Tenkumo K, et al. Effect of the Renin Inhibitor Aliskiren Against Retinal Ischemia-reperfusion Injury. Exp Eye Res. 2014;122:110-8. PubMed PMID: 24709336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury. AU - Tenkumo,Kaori, AU - Hirooka,Kazuyuki, AU - Sherajee,Shamshad J, AU - Nakamura,Takehiro, AU - Itano,Toshifumi, AU - Nitta,Eri, AU - Fujita,Tomoyoshi, AU - Nishiyama,Akira, AU - Shiraga,Fumio, Y1 - 2014/04/05/ PY - 2013/09/12/received PY - 2014/03/09/revised PY - 2014/03/25/accepted PY - 2014/4/9/entrez PY - 2014/4/9/pubmed PY - 2014/7/19/medline KW - (pro)renin KW - aliskiren KW - angiotensin II type 1 receptor (AT1-R) KW - angiotensinogen KW - renin KW - renin-angiotensin-aldosterone-system KW - retinal ischemia SP - 110 EP - 8 JF - Experimental eye research JO - Exp Eye Res VL - 122 N2 - The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg. At 7 days after ischemia, retinal damage was evaluated by measuring the retinal thickness and the number of retinal ganglion cells. Western blot was used to measure changes in the (pro)renin receptor expression. Retinal mRNA expressions of prorenin, angiotensinogen and angiotensin II type 1 receptor (AT1-R) were measured by real-time polymerase chain reaction. Rats were treated with the renin inhibitor, aliskiren. Although the number of retinal ganglion cells and the inner retinal thickness were significantly decreased at 7 days after ischemia, treatment with aliskiren significantly inhibited retinal ischemic injury. Administration of aliskiren increased mRNA expression of prorenin in the retina at 3 h after the reperfusion. The expression of the (pro)renin receptor was not changed after ischemia-reperfusion injury with or without aliskiren. Although there was an increase in the retinal expression of AT1-R at 3 h after the reperfusion, aliskiren administration suppressed this expression. A renin inhibitor attenuated subsequent ischemic damage in the rat retina via the inhibition of the prorenin-induced angiotensin generation. SN - 1096-0007 UR - https://www.unboundmedicine.com/medline/citation/24709336/Effect_of_the_renin_inhibitor_aliskiren_against_retinal_ischemia_reperfusion_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4835(14)00088-8 DB - PRIME DP - Unbound Medicine ER -