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Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels.

Abstract

OBJECTIVES

To investigate expression of pentraxin 3, long (PTX3) in patients with acute coronary syndrome (ACS) and its correlation with matrix metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) levels.

METHODS

Patients with ACS were randomly assigned to the ACS group (subdivided into unstable angina pectoris [UAP] and acute myocardial infarction [AMI]). Healthy participants and patients with stable angina pectoris (SAP) were enrolled as controls. Mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were measured by enzyme-linked immunosorbent assay.

RESULTS

The ACS group comprised 200 patients (80 in the UAP subgroup; 120 in the AMI subgroup). The control group comprised 130 participants (80 healthy volunteers and 50 patients with SAP). PTX3 expression was significantly higher in the ACS group compared with controls (3.64 ± 0.49 versus 1.85 ± 0.65 ng/ml), and significantly higher in the AMI compared with the UAP subgroup (5.44 ± 0.47 versus 3.39 ± 0.59 ng/ml). Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 ± 14.22 versus 23.14 ± 0.62 ng/ml; 4.88 ± 1.76 versus 1.26 ± 0.19 ng/ml, respectively), and significantly higher in the AMI compared with the UAP subgroup (58.13 ± 7.24 versus 31.77 ± 3.61 ng/ml; 5.80 ± 1.46 versus 3.27 ± 0.83 ng/ml, respectively). PTX3 expression, and MMP-9 and CRP levels in the SAP subgroup, were not significantly different from the healthy participants. PTX3 expression positively correlated with MMP-9 and CRP levels.

CONCLUSIONS

In patients with ACS, peripheral blood mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were significantly enhanced compared with controls; in addition, PTX3 expression positively correlated with MMP-9 and CRP levels. PTX3 may be involved in ACS pathogenesis.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.

    ,

    Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.

    ,

    Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.

    ,

    Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.

    ,

    The Hospital of the Chinese People's Armed Police Force Academy, Langfang, Hebei, China.

    ,

    Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China.

    Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan, China yao.zhen@126.com.

    Source

    MeSH

    Acute Coronary Syndrome
    Aged
    Angina, Stable
    Angina, Unstable
    C-Reactive Protein
    Case-Control Studies
    Enzyme-Linked Immunosorbent Assay
    Female
    Gene Expression Regulation
    Humans
    Leukocytes, Mononuclear
    Male
    Matrix Metalloproteinase 9
    Middle Aged
    Prognosis
    Serum Amyloid P-Component

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24709882

    Citation

    Ma, Ruilian, et al. "Pentraxin 3, Long Expression in Mononuclear Cells of Patients With Acute Coronary Syndrome: Correlation With C-reactive Protein and Matrix Metalloproteinase-9 Levels." The Journal of International Medical Research, vol. 42, no. 3, 2014, pp. 677-83.
    Ma R, Zhang W, Wang T, et al. Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels. J Int Med Res. 2014;42(3):677-83.
    Ma, R., Zhang, W., Wang, T., He, X., Huang, Z., Zhu, J., & Yao, Z. (2014). Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels. The Journal of International Medical Research, 42(3), pp. 677-83. doi:10.1177/0300060513507387.
    Ma R, et al. Pentraxin 3, Long Expression in Mononuclear Cells of Patients With Acute Coronary Syndrome: Correlation With C-reactive Protein and Matrix Metalloproteinase-9 Levels. J Int Med Res. 2014;42(3):677-83. PubMed PMID: 24709882.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels. AU - Ma,Ruilian, AU - Zhang,Wei, AU - Wang,Tiansong, AU - He,Ximin, AU - Huang,Zichong, AU - Zhu,Jinguo, AU - Yao,Zhen, Y1 - 2014/04/07/ PY - 2013/07/17/received PY - 2013/08/10/accepted PY - 2014/4/9/entrez PY - 2014/4/9/pubmed PY - 2016/2/16/medline KW - C-reactive protein KW - Pentraxin-related protein PTX3 KW - acute coronary syndrome KW - matrix metalloproteinase-9 KW - mononuclear cell SP - 677 EP - 83 JF - The Journal of international medical research JO - J. Int. Med. Res. VL - 42 IS - 3 N2 - OBJECTIVES: To investigate expression of pentraxin 3, long (PTX3) in patients with acute coronary syndrome (ACS) and its correlation with matrix metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) levels. METHODS: Patients with ACS were randomly assigned to the ACS group (subdivided into unstable angina pectoris [UAP] and acute myocardial infarction [AMI]). Healthy participants and patients with stable angina pectoris (SAP) were enrolled as controls. Mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were measured by enzyme-linked immunosorbent assay. RESULTS: The ACS group comprised 200 patients (80 in the UAP subgroup; 120 in the AMI subgroup). The control group comprised 130 participants (80 healthy volunteers and 50 patients with SAP). PTX3 expression was significantly higher in the ACS group compared with controls (3.64 ± 0.49 versus 1.85 ± 0.65 ng/ml), and significantly higher in the AMI compared with the UAP subgroup (5.44 ± 0.47 versus 3.39 ± 0.59 ng/ml). Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 ± 14.22 versus 23.14 ± 0.62 ng/ml; 4.88 ± 1.76 versus 1.26 ± 0.19 ng/ml, respectively), and significantly higher in the AMI compared with the UAP subgroup (58.13 ± 7.24 versus 31.77 ± 3.61 ng/ml; 5.80 ± 1.46 versus 3.27 ± 0.83 ng/ml, respectively). PTX3 expression, and MMP-9 and CRP levels in the SAP subgroup, were not significantly different from the healthy participants. PTX3 expression positively correlated with MMP-9 and CRP levels. CONCLUSIONS: In patients with ACS, peripheral blood mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were significantly enhanced compared with controls; in addition, PTX3 expression positively correlated with MMP-9 and CRP levels. PTX3 may be involved in ACS pathogenesis. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/24709882/Pentraxin_3_long_expression_in_mononuclear_cells_of_patients_with_acute_coronary_syndrome:_Correlation_with_C_reactive_protein_and_matrix_metalloproteinase_9_levels_ L2 - http://journals.sagepub.com/doi/full/10.1177/0300060513507387?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -