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Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial.

Abstract

BACKGROUND

Mild cognitive impairment (MCI) is a well-recognised risk factor for dementia and represents a vital opportunity for intervening. Exercise is a promising strategy for combating cognitive decline by improving brain structure and function. Specifically, aerobic training (AT) improved spatial memory and hippocampal volume in healthy community-dwelling older adults. In older women with probable MCI, we previously demonstrated that resistance training (RT) and AT improved memory. In this secondary analysis, we investigated: (1) the effect of RT and AT on hippocampal volume and (2) the association between change in hippocampal volume and change in memory.

METHODS

86 women aged 70-80 years with probable MCI were randomly assigned to a 6-month, twice-weekly programme of: (1) AT, (2) RT or (3) balance and tone training (BAT; ie, control). At baseline and trial completion, participants performed a 3T MRI scan to determine hippocampal volume. Verbal memory and learning were assessed by Rey's Auditory Verbal Learning Test.

RESULTS

Compared with the BAT group, AT significantly improved left, right and total hippocampal volumes (p≤0.03). After accounting for baseline cognitive function and experimental group, increased left hippocampal volume was independently associated with reduced verbal memory and learning performance as indexed by loss after interference (r=0.42, p=0.03).

CONCLUSIONS

Aerobic training significantly increased hippocampal volume in older women with probable MCI. More research is needed to ascertain the relevance of exercise-induced changes in hippocampal volume on memory performance in older adults with MCI.

TRAIL REGISTRATION NUMBER

NCT00958867.

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  • Authors+Show Affiliations

    ,

    Maastricht University, Maastricht, The Netherlands.

    ,

    Department of Physical Therapy, UBC, Vancouver, British Columbia, Canada Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.

    ,

    Department of Psychology, UBC, Vancouver, British Columbia, Canada.

    ,

    Department of Physical Therapy, UBC, Vancouver, British Columbia, Canada Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.

    ,

    Centre for Clinical Epidemiology and Evaluation, UBC, Vancouver, British Columbia, Canada.

    ,

    Department of Family Practice, Faculty of Medicine, UBC, Vancouver, British Columbia, Canada.

    Department of Physical Therapy, UBC, Vancouver, British Columbia, Canada Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada Department of Family Practice, Faculty of Medicine, UBC, Vancouver, British Columbia, Canada Centre for Hip Health and Mobility, Vancouver, British Columbia, Canada.

    Source

    British journal of sports medicine 49:4 2015 Feb pg 248-54

    MeSH

    Aged
    Aged, 80 and over
    Cognitive Dysfunction
    Exercise
    Female
    Hippocampus
    Humans
    Magnetic Resonance Imaging
    Memory Disorders
    Organ Size
    Resistance Training
    Single-Blind Method
    Treatment Outcome

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24711660

    Citation

    ten Brinke, Lisanne F., et al. "Aerobic Exercise Increases Hippocampal Volume in Older Women With Probable Mild Cognitive Impairment: a 6-month Randomised Controlled Trial." British Journal of Sports Medicine, vol. 49, no. 4, 2015, pp. 248-54.
    ten Brinke LF, Bolandzadeh N, Nagamatsu LS, et al. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. Br J Sports Med. 2015;49(4):248-54.
    ten Brinke, L. F., Bolandzadeh, N., Nagamatsu, L. S., Hsu, C. L., Davis, J. C., Miran-Khan, K., & Liu-Ambrose, T. (2015). Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. British Journal of Sports Medicine, 49(4), pp. 248-54. doi:10.1136/bjsports-2013-093184.
    ten Brinke LF, et al. Aerobic Exercise Increases Hippocampal Volume in Older Women With Probable Mild Cognitive Impairment: a 6-month Randomised Controlled Trial. Br J Sports Med. 2015;49(4):248-54. PubMed PMID: 24711660.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. AU - ten Brinke,Lisanne F, AU - Bolandzadeh,Niousha, AU - Nagamatsu,Lindsay S, AU - Hsu,Chun Liang, AU - Davis,Jennifer C, AU - Miran-Khan,Karim, AU - Liu-Ambrose,Teresa, Y1 - 2014/04/07/ PY - 2014/4/9/entrez PY - 2014/4/9/pubmed PY - 2015/10/17/medline KW - Aerobic fitness/Vo2 Max KW - Aging KW - Cardiovascular KW - Exercise KW - Gender issues SP - 248 EP - 54 JF - British journal of sports medicine JO - Br J Sports Med VL - 49 IS - 4 N2 - BACKGROUND: Mild cognitive impairment (MCI) is a well-recognised risk factor for dementia and represents a vital opportunity for intervening. Exercise is a promising strategy for combating cognitive decline by improving brain structure and function. Specifically, aerobic training (AT) improved spatial memory and hippocampal volume in healthy community-dwelling older adults. In older women with probable MCI, we previously demonstrated that resistance training (RT) and AT improved memory. In this secondary analysis, we investigated: (1) the effect of RT and AT on hippocampal volume and (2) the association between change in hippocampal volume and change in memory. METHODS: 86 women aged 70-80 years with probable MCI were randomly assigned to a 6-month, twice-weekly programme of: (1) AT, (2) RT or (3) balance and tone training (BAT; ie, control). At baseline and trial completion, participants performed a 3T MRI scan to determine hippocampal volume. Verbal memory and learning were assessed by Rey's Auditory Verbal Learning Test. RESULTS: Compared with the BAT group, AT significantly improved left, right and total hippocampal volumes (p≤0.03). After accounting for baseline cognitive function and experimental group, increased left hippocampal volume was independently associated with reduced verbal memory and learning performance as indexed by loss after interference (r=0.42, p=0.03). CONCLUSIONS: Aerobic training significantly increased hippocampal volume in older women with probable MCI. More research is needed to ascertain the relevance of exercise-induced changes in hippocampal volume on memory performance in older adults with MCI. TRAIL REGISTRATION NUMBER: NCT00958867. SN - 1473-0480 UR - https://www.unboundmedicine.com/medline/citation/24711660/Aerobic_exercise_increases_hippocampal_volume_in_older_women_with_probable_mild_cognitive_impairment:_a_6_month_randomised_controlled_trial_ L2 - http://bjsm.bmj.com/cgi/pmidlookup?view=long&pmid=24711660 DB - PRIME DP - Unbound Medicine ER -