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Association between folate intake and the risk of lung cancer: a dose-response meta-analysis of prospective studies.
PLoS One 2014; 9(4):e93465Plos

Abstract

BACKGROUND

Studies have reported inconsistent results regarding the existence of an association between folate intake and the risk of lung cancer. The purpose of this study was to summarize the evidence from prospective cohort studies regarding this relationship by using a dose-response meta-analytic approach.

METHODOLOGY AND PRINCIPAL FINDINGS

In September 2013, we performed electronic searches in PubMed, Embase, and the Cochrane Library to identify studies examining the effect of folate intake on the incidence of lung cancer. Only prospective cohort studies that reported the effect estimates about the incidence of lung cancer with 95% confidence intervals (CIs) for more than 2 categories of folate intake were included. Overall, we examined 9 cohort studies reporting the data of 566,921 individuals. High folate intake had little effect on the risk of lung cancer (risk ratio [RR], 0.92; 95% CI, 0.84-1.01; P = 0.076). Dose-response meta-analysis also suggested that a 100 µg/day increase in folate intake had no significant effect on the risk of lung cancer (RR, 0.99; 95% CI, 0.97-1.01; P = 0.318). Subgroup analysis suggested that the potential protective effect of low folate intake (100-299 µg/day) was more evident in women than men, while the opposite was true of high folate intake (>400 µg/day). Finally, subgroup analyses of a 100 µg/day increment in folate intake indicated that its potential protective effect was more evident in men than in women.

CONCLUSION/SIGNIFICANCE

Our study revealed that folate intake had little or no effect on the risk of lung cancer. Subgroup analyses indicated that an increased folate intake was associated with a reduced risk of lung cancer in men. Furthermore, low folate intake may be a protective factor for women, and high folate intake for men.

Authors+Show Affiliations

Department of Oncology, Shanghai Seventh People's Hospital, Shanghai, China.Department of Oncology, Shanghai Seventh People's Hospital, Shanghai, China.Department of Oncology, Shanghai Seventh People's Hospital, Shanghai, China.Department of Oncology, Shanghai Seventh People's Hospital, Shanghai, China.Department of Oncology, Shanghai Seventh People's Hospital, Shanghai, China.Department of Rehabilitation Institute, Shanghai Seventh People's Hospital, Shanghai, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24713625

Citation

Zhang, Yu-Fei, et al. "Association Between Folate Intake and the Risk of Lung Cancer: a Dose-response Meta-analysis of Prospective Studies." PloS One, vol. 9, no. 4, 2014, pp. e93465.
Zhang YF, Zhou L, Zhang HW, et al. Association between folate intake and the risk of lung cancer: a dose-response meta-analysis of prospective studies. PLoS ONE. 2014;9(4):e93465.
Zhang, Y. F., Zhou, L., Zhang, H. W., Hou, A. J., Gao, H. F., & Zhou, Y. H. (2014). Association between folate intake and the risk of lung cancer: a dose-response meta-analysis of prospective studies. PloS One, 9(4), pp. e93465. doi:10.1371/journal.pone.0093465.
Zhang YF, et al. Association Between Folate Intake and the Risk of Lung Cancer: a Dose-response Meta-analysis of Prospective Studies. PLoS ONE. 2014;9(4):e93465. PubMed PMID: 24713625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between folate intake and the risk of lung cancer: a dose-response meta-analysis of prospective studies. AU - Zhang,Yu-Fei, AU - Zhou,Li, AU - Zhang,Hong-Wei, AU - Hou,An-Ji, AU - Gao,Hong-Fang, AU - Zhou,Yu-Hao, Y1 - 2014/04/08/ PY - 2014/01/23/received PY - 2014/03/04/accepted PY - 2014/4/10/entrez PY - 2014/4/10/pubmed PY - 2014/12/15/medline SP - e93465 EP - e93465 JF - PloS one JO - PLoS ONE VL - 9 IS - 4 N2 - BACKGROUND: Studies have reported inconsistent results regarding the existence of an association between folate intake and the risk of lung cancer. The purpose of this study was to summarize the evidence from prospective cohort studies regarding this relationship by using a dose-response meta-analytic approach. METHODOLOGY AND PRINCIPAL FINDINGS: In September 2013, we performed electronic searches in PubMed, Embase, and the Cochrane Library to identify studies examining the effect of folate intake on the incidence of lung cancer. Only prospective cohort studies that reported the effect estimates about the incidence of lung cancer with 95% confidence intervals (CIs) for more than 2 categories of folate intake were included. Overall, we examined 9 cohort studies reporting the data of 566,921 individuals. High folate intake had little effect on the risk of lung cancer (risk ratio [RR], 0.92; 95% CI, 0.84-1.01; P = 0.076). Dose-response meta-analysis also suggested that a 100 µg/day increase in folate intake had no significant effect on the risk of lung cancer (RR, 0.99; 95% CI, 0.97-1.01; P = 0.318). Subgroup analysis suggested that the potential protective effect of low folate intake (100-299 µg/day) was more evident in women than men, while the opposite was true of high folate intake (>400 µg/day). Finally, subgroup analyses of a 100 µg/day increment in folate intake indicated that its potential protective effect was more evident in men than in women. CONCLUSION/SIGNIFICANCE: Our study revealed that folate intake had little or no effect on the risk of lung cancer. Subgroup analyses indicated that an increased folate intake was associated with a reduced risk of lung cancer in men. Furthermore, low folate intake may be a protective factor for women, and high folate intake for men. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24713625/Association_between_folate_intake_and_the_risk_of_lung_cancer:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - http://dx.plos.org/10.1371/journal.pone.0093465 DB - PRIME DP - Unbound Medicine ER -