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Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity?
Pancreas. 2014 Jul; 43(5):730-4.P

Abstract

OBJECTIVES

The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors.

METHODS

This is an analytical observational study of cases and controls for a sample of patients with chronic alcoholic and nonalcoholic liver disease. Exocrine pancreatic insufficiency was diagnosed using the C mixed-triglyceride breath test. Patients with abdominal pain underwent endoscopic ultrasonography for CP evaluation using the Wiersema criteria.

RESULTS

A total of 154 patients were included, 129 with alcoholic liver disease (83 with cirrhosis) and 25 with nonalcoholic liver disease. Exocrine pancreatic insufficiency was found in 55.2% versus 16.7% (P < 0.001), 70% of patients without cirrhosis compared with 46.2% of patients with cirrhosis had pancreatic insufficiency (P = 0.017), and 82.7% of patients with alcoholic liver disease and abdominal pain had CP (P < 0.001). Exocrine pancreatic insufficiency was associated with the male sex, alcohol intake, abdominal pain, degree of liver failure, and the absence of portal hypertension. Chronic pancreatitis was correlated with age younger than 55 years and abdominal pain.

CONCLUSIONS

Patients with alcoholic liver disease had a high prevalence of EPI and CP; this prevalence was even higher in patients who have not yet developed cirrhosis with liver failure or portal hypertension.

Authors+Show Affiliations

From the *Hepatorenal Unit, Gastroenterology and Hepatology Department, †Hepatorenal Unit, Nephrology Department, ‡Gastroenterology and Hepatology Department, and §Investigation Unit, La Mancha-Centro Hospital Complex, Alcázar de San Juan, Ciudad Real, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

24713840

Citation

Aoufi Rabih, Sami, et al. "Exocrine Pancreatic Insufficiency and Chronic Pancreatitis in Chronic Alcoholic Liver Disease: Coincidence or Shared Toxicity?" Pancreas, vol. 43, no. 5, 2014, pp. 730-4.
Aoufi Rabih S, García Agudo R, Legaz Huidobro ML, et al. Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity? Pancreas. 2014;43(5):730-4.
Aoufi Rabih, S., García Agudo, R., Legaz Huidobro, M. L., Ynfante Ferrús, M., González Carro, P., Pérez Roldán, F., Ruiz Carrillo, F., & Tenías Burillo, J. M. (2014). Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity? Pancreas, 43(5), 730-4. https://doi.org/10.1097/MPA.0000000000000085
Aoufi Rabih S, et al. Exocrine Pancreatic Insufficiency and Chronic Pancreatitis in Chronic Alcoholic Liver Disease: Coincidence or Shared Toxicity. Pancreas. 2014;43(5):730-4. PubMed PMID: 24713840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity? AU - Aoufi Rabih,Sami, AU - García Agudo,Rebeca, AU - Legaz Huidobro,María Luisa, AU - Ynfante Ferrús,Marina, AU - González Carro,Pedro, AU - Pérez Roldán,Francisco, AU - Ruiz Carrillo,Francisco, AU - Tenías Burillo,José María, PY - 2014/4/10/entrez PY - 2014/4/10/pubmed PY - 2015/2/11/medline SP - 730 EP - 4 JF - Pancreas JO - Pancreas VL - 43 IS - 5 N2 - OBJECTIVES: The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS: This is an analytical observational study of cases and controls for a sample of patients with chronic alcoholic and nonalcoholic liver disease. Exocrine pancreatic insufficiency was diagnosed using the C mixed-triglyceride breath test. Patients with abdominal pain underwent endoscopic ultrasonography for CP evaluation using the Wiersema criteria. RESULTS: A total of 154 patients were included, 129 with alcoholic liver disease (83 with cirrhosis) and 25 with nonalcoholic liver disease. Exocrine pancreatic insufficiency was found in 55.2% versus 16.7% (P < 0.001), 70% of patients without cirrhosis compared with 46.2% of patients with cirrhosis had pancreatic insufficiency (P = 0.017), and 82.7% of patients with alcoholic liver disease and abdominal pain had CP (P < 0.001). Exocrine pancreatic insufficiency was associated with the male sex, alcohol intake, abdominal pain, degree of liver failure, and the absence of portal hypertension. Chronic pancreatitis was correlated with age younger than 55 years and abdominal pain. CONCLUSIONS: Patients with alcoholic liver disease had a high prevalence of EPI and CP; this prevalence was even higher in patients who have not yet developed cirrhosis with liver failure or portal hypertension. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/24713840/Exocrine_pancreatic_insufficiency_and_chronic_pancreatitis_in_chronic_alcoholic_liver_disease:_coincidence_or_shared_toxicity L2 - https://doi.org/10.1097/MPA.0000000000000085 DB - PRIME DP - Unbound Medicine ER -