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Relationship between 25-hydroxyvitamin D concentrations, serum calcium, and parathyroid hormone in apparently healthy Syrian people.
Arch Osteoporos. 2014; 9:176.AO

Abstract

Vitamin D deficiency (25-hydroxyvitamin D (25OHD) <25 nmol/L) was common in a convenience sample of apparently healthy Syrian adults. Female gender, season, and concealing clothing were independent predictors of vitamin D deficiency. Community-based research is needed to identify vulnerable subgroups and inform public health actions.

PURPOSE

Optimal vitamin D status for bone health has been inferred from the determination of serum 25OHD levels below which there is an increase in serum parathyroid hormone (PTH). Studies worldwide showed high prevalence of hypovitaminosis D even in sunny countries. There is little evidence about its prevalence among Syrian adult population. We aimed to assess the serum levels of 25OHD and factors related to vitamin D inadequacy and its relation to serum PTH and calcium among apparently healthy adults.

METHODS

Serum 25OHD and PTH measurements were obtained from 372 subjects aged 18-62 years living in Damascus and its surroundings, between April 2011 and March 2013. Binary logistic regression was used to assess risk factors for hypovitaminosis D.

RESULTS

The mean (standard deviation (SD)) 25OHD level was 24.7 (16.9) nmol/L [9.8 (6.7) ng/mL] and was higher in men than women (p < 0.001). Levels <25, <50, and <75 nmol/L were detected in 61, 90.1, and 99.2 % of the participants, respectively. Season influenced vitamin D status in men but not in women (p < 0.001). Female gender and wearing the veil (hijab) were independent predictors of vitamin D deficiency (25OHD <25 nmol/L). PTH was significantly higher below this threshold (p < 0.001). Serum 25OHD <25 nmol/L, sex, and age ≥ 35 years were statistically significant factors for PTH elevation.

CONCLUSIONS

Vitamin D deficiency was highly prevalent in our sample. Further research is needed to identify population groups vulnerable for hypovitaminosis D and specify its predictors and inform the necessary public health measures.

Authors+Show Affiliations

Department of Internal Medicine, Faculty of Medicine, Damascus University, P.O. Box 9241, Damascus, Syria, rimasayedhassan@gmail.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24715441

Citation

Sayed-Hassan, Rima, et al. "Relationship Between 25-hydroxyvitamin D Concentrations, Serum Calcium, and Parathyroid Hormone in Apparently Healthy Syrian People." Archives of Osteoporosis, vol. 9, 2014, p. 176.
Sayed-Hassan R, Abazid N, Alourfi Z. Relationship between 25-hydroxyvitamin D concentrations, serum calcium, and parathyroid hormone in apparently healthy Syrian people. Arch Osteoporos. 2014;9:176.
Sayed-Hassan, R., Abazid, N., & Alourfi, Z. (2014). Relationship between 25-hydroxyvitamin D concentrations, serum calcium, and parathyroid hormone in apparently healthy Syrian people. Archives of Osteoporosis, 9, 176. https://doi.org/10.1007/s11657-014-0176-1
Sayed-Hassan R, Abazid N, Alourfi Z. Relationship Between 25-hydroxyvitamin D Concentrations, Serum Calcium, and Parathyroid Hormone in Apparently Healthy Syrian People. Arch Osteoporos. 2014;9:176. PubMed PMID: 24715441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between 25-hydroxyvitamin D concentrations, serum calcium, and parathyroid hormone in apparently healthy Syrian people. AU - Sayed-Hassan,Rima, AU - Abazid,Nizar, AU - Alourfi,Zaynab, Y1 - 2014/04/09/ PY - 2013/11/27/received PY - 2014/03/24/accepted PY - 2014/4/10/entrez PY - 2014/4/10/pubmed PY - 2014/9/4/medline SP - 176 EP - 176 JF - Archives of osteoporosis JO - Arch Osteoporos VL - 9 N2 - UNLABELLED: Vitamin D deficiency (25-hydroxyvitamin D (25OHD) <25 nmol/L) was common in a convenience sample of apparently healthy Syrian adults. Female gender, season, and concealing clothing were independent predictors of vitamin D deficiency. Community-based research is needed to identify vulnerable subgroups and inform public health actions. PURPOSE: Optimal vitamin D status for bone health has been inferred from the determination of serum 25OHD levels below which there is an increase in serum parathyroid hormone (PTH). Studies worldwide showed high prevalence of hypovitaminosis D even in sunny countries. There is little evidence about its prevalence among Syrian adult population. We aimed to assess the serum levels of 25OHD and factors related to vitamin D inadequacy and its relation to serum PTH and calcium among apparently healthy adults. METHODS: Serum 25OHD and PTH measurements were obtained from 372 subjects aged 18-62 years living in Damascus and its surroundings, between April 2011 and March 2013. Binary logistic regression was used to assess risk factors for hypovitaminosis D. RESULTS: The mean (standard deviation (SD)) 25OHD level was 24.7 (16.9) nmol/L [9.8 (6.7) ng/mL] and was higher in men than women (p < 0.001). Levels <25, <50, and <75 nmol/L were detected in 61, 90.1, and 99.2 % of the participants, respectively. Season influenced vitamin D status in men but not in women (p < 0.001). Female gender and wearing the veil (hijab) were independent predictors of vitamin D deficiency (25OHD <25 nmol/L). PTH was significantly higher below this threshold (p < 0.001). Serum 25OHD <25 nmol/L, sex, and age ≥ 35 years were statistically significant factors for PTH elevation. CONCLUSIONS: Vitamin D deficiency was highly prevalent in our sample. Further research is needed to identify population groups vulnerable for hypovitaminosis D and specify its predictors and inform the necessary public health measures. SN - 1862-3514 UR - https://www.unboundmedicine.com/medline/citation/24715441/Relationship_between_25_hydroxyvitamin_D_concentrations_serum_calcium_and_parathyroid_hormone_in_apparently_healthy_Syrian_people_ L2 - https://dx.doi.org/10.1007/s11657-014-0176-1 DB - PRIME DP - Unbound Medicine ER -