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Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study.
Hepatology 2014; 60(2):588-97Hep

Abstract

The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary recommendations has been shown to reduce risk of many cancers, but whether such diets are associated with HCC and CLD is unknown. We prospectively evaluated the association of two dietary indices, the Healthy Eating Index-2010 (HEI-2010) and the alternate Mediterranean Diet Score (aMED), with HCC incidence and CLD mortality in a large U.S. prospective cohort. We calculated the HEI-2010 and aMED scores for 494,942 participants in the National Institutes of Health-AARP Diet and Health study, based on typical diet assessed using a food frequency questionnaire FFQ between 1995 and 1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of each index were estimated using Cox's proportional hazards regression, after adjusting for alcohol intake, smoking, body mass index, diabetes, and other covariates. A total of 509 HCC cases (1995-2006) and 1,053 CLD deaths (1995-2011) were documented during follow-up. Higher HEI-2010 scores, reflecting favorable adherence to dietary guidelines, were associated with lower risk of HCC (HR, 0.72, 95% CI: 0.53-0.97 for the highest quintile, compared to lowest; P trend = 0.03) and lower mortality resulting from CLD (HR, 0.57; 95% CI: 0.46-0.71; P trend < 0.0001). High aMED scores were also associated with lower risk of HCC (HR, 0.62; 95% CI: 0.47-0.84; P trend = 0.0002) and lower risk of CLD mortality (HR, 0.52; 95% CI: 0.42-0.65; P trend < 0.0001).

CONCLUSIONS

Adhering to dietary recommendations may reduce the risk of developing HCC and dying of CLD.

Authors+Show Affiliations

Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

24715615

Citation

Li, Wen-Qing, et al. "Index-based Dietary Patterns and Risk of Incident Hepatocellular Carcinoma and Mortality From Chronic Liver Disease in a Prospective Study." Hepatology (Baltimore, Md.), vol. 60, no. 2, 2014, pp. 588-97.
Li WQ, Park Y, McGlynn KA, et al. Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology. 2014;60(2):588-97.
Li, W. Q., Park, Y., McGlynn, K. A., Hollenbeck, A. R., Taylor, P. R., Goldstein, A. M., & Freedman, N. D. (2014). Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology (Baltimore, Md.), 60(2), pp. 588-97. doi:10.1002/hep.27160.
Li WQ, et al. Index-based Dietary Patterns and Risk of Incident Hepatocellular Carcinoma and Mortality From Chronic Liver Disease in a Prospective Study. Hepatology. 2014;60(2):588-97. PubMed PMID: 24715615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. AU - Li,Wen-Qing, AU - Park,Yikyung, AU - McGlynn,Katherine A, AU - Hollenbeck,Albert R, AU - Taylor,Philip R, AU - Goldstein,Alisa M, AU - Freedman,Neal D, Y1 - 2014/05/20/ PY - 2014/01/07/received PY - 2014/04/01/accepted PY - 2014/4/10/entrez PY - 2014/4/10/pubmed PY - 2014/9/23/medline SP - 588 EP - 97 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 60 IS - 2 N2 - UNLABELLED: The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary recommendations has been shown to reduce risk of many cancers, but whether such diets are associated with HCC and CLD is unknown. We prospectively evaluated the association of two dietary indices, the Healthy Eating Index-2010 (HEI-2010) and the alternate Mediterranean Diet Score (aMED), with HCC incidence and CLD mortality in a large U.S. prospective cohort. We calculated the HEI-2010 and aMED scores for 494,942 participants in the National Institutes of Health-AARP Diet and Health study, based on typical diet assessed using a food frequency questionnaire FFQ between 1995 and 1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of each index were estimated using Cox's proportional hazards regression, after adjusting for alcohol intake, smoking, body mass index, diabetes, and other covariates. A total of 509 HCC cases (1995-2006) and 1,053 CLD deaths (1995-2011) were documented during follow-up. Higher HEI-2010 scores, reflecting favorable adherence to dietary guidelines, were associated with lower risk of HCC (HR, 0.72, 95% CI: 0.53-0.97 for the highest quintile, compared to lowest; P trend = 0.03) and lower mortality resulting from CLD (HR, 0.57; 95% CI: 0.46-0.71; P trend < 0.0001). High aMED scores were also associated with lower risk of HCC (HR, 0.62; 95% CI: 0.47-0.84; P trend = 0.0002) and lower risk of CLD mortality (HR, 0.52; 95% CI: 0.42-0.65; P trend < 0.0001). CONCLUSIONS: Adhering to dietary recommendations may reduce the risk of developing HCC and dying of CLD. SN - 1527-3350 UR - https://www.unboundmedicine.com/medline/citation/24715615/Index_based_dietary_patterns_and_risk_of_incident_hepatocellular_carcinoma_and_mortality_from_chronic_liver_disease_in_a_prospective_study_ L2 - https://doi.org/10.1002/hep.27160 DB - PRIME DP - Unbound Medicine ER -