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Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study.

Abstract

The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary recommendations has been shown to reduce risk of many cancers, but whether such diets are associated with HCC and CLD is unknown. We prospectively evaluated the association of two dietary indices, the Healthy Eating Index-2010 (HEI-2010) and the alternate Mediterranean Diet Score (aMED), with HCC incidence and CLD mortality in a large U.S. prospective cohort. We calculated the HEI-2010 and aMED scores for 494,942 participants in the National Institutes of Health-AARP Diet and Health study, based on typical diet assessed using a food frequency questionnaire FFQ between 1995 and 1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of each index were estimated using Cox's proportional hazards regression, after adjusting for alcohol intake, smoking, body mass index, diabetes, and other covariates. A total of 509 HCC cases (1995-2006) and 1,053 CLD deaths (1995-2011) were documented during follow-up. Higher HEI-2010 scores, reflecting favorable adherence to dietary guidelines, were associated with lower risk of HCC (HR, 0.72, 95% CI: 0.53-0.97 for the highest quintile, compared to lowest; P trend = 0.03) and lower mortality resulting from CLD (HR, 0.57; 95% CI: 0.46-0.71; P trend < 0.0001). High aMED scores were also associated with lower risk of HCC (HR, 0.62; 95% CI: 0.47-0.84; P trend = 0.0002) and lower risk of CLD mortality (HR, 0.52; 95% CI: 0.42-0.65; P trend < 0.0001).

CONCLUSIONS

Adhering to dietary recommendations may reduce the risk of developing HCC and dying of CLD.

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  • Authors+Show Affiliations

    ,

    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI.

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    Source

    Hepatology (Baltimore, Md.) 60:2 2014 Aug pg 588-97

    MeSH

    Aged
    Carcinoma, Hepatocellular
    Chronic Disease
    Diet, Mediterranean
    Feeding Behavior
    Female
    Follow-Up Studies
    Humans
    Incidence
    Life Style
    Liver Diseases
    Liver Neoplasms
    Male
    Middle Aged
    Nutrition Surveys
    Prospective Studies
    Risk Factors
    Risk Reduction Behavior
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    24715615

    Citation

    Li, Wen-Qing, et al. "Index-based Dietary Patterns and Risk of Incident Hepatocellular Carcinoma and Mortality From Chronic Liver Disease in a Prospective Study." Hepatology (Baltimore, Md.), vol. 60, no. 2, 2014, pp. 588-97.
    Li WQ, Park Y, McGlynn KA, et al. Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology. 2014;60(2):588-97.
    Li, W. Q., Park, Y., McGlynn, K. A., Hollenbeck, A. R., Taylor, P. R., Goldstein, A. M., & Freedman, N. D. (2014). Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology (Baltimore, Md.), 60(2), pp. 588-97. doi:10.1002/hep.27160.
    Li WQ, et al. Index-based Dietary Patterns and Risk of Incident Hepatocellular Carcinoma and Mortality From Chronic Liver Disease in a Prospective Study. Hepatology. 2014;60(2):588-97. PubMed PMID: 24715615.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. AU - Li,Wen-Qing, AU - Park,Yikyung, AU - McGlynn,Katherine A, AU - Hollenbeck,Albert R, AU - Taylor,Philip R, AU - Goldstein,Alisa M, AU - Freedman,Neal D, Y1 - 2014/05/20/ PY - 2014/01/07/received PY - 2014/04/01/accepted PY - 2014/4/10/entrez PY - 2014/4/10/pubmed PY - 2014/9/23/medline SP - 588 EP - 97 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 60 IS - 2 N2 - UNLABELLED: The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary recommendations has been shown to reduce risk of many cancers, but whether such diets are associated with HCC and CLD is unknown. We prospectively evaluated the association of two dietary indices, the Healthy Eating Index-2010 (HEI-2010) and the alternate Mediterranean Diet Score (aMED), with HCC incidence and CLD mortality in a large U.S. prospective cohort. We calculated the HEI-2010 and aMED scores for 494,942 participants in the National Institutes of Health-AARP Diet and Health study, based on typical diet assessed using a food frequency questionnaire FFQ between 1995 and 1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of each index were estimated using Cox's proportional hazards regression, after adjusting for alcohol intake, smoking, body mass index, diabetes, and other covariates. A total of 509 HCC cases (1995-2006) and 1,053 CLD deaths (1995-2011) were documented during follow-up. Higher HEI-2010 scores, reflecting favorable adherence to dietary guidelines, were associated with lower risk of HCC (HR, 0.72, 95% CI: 0.53-0.97 for the highest quintile, compared to lowest; P trend = 0.03) and lower mortality resulting from CLD (HR, 0.57; 95% CI: 0.46-0.71; P trend < 0.0001). High aMED scores were also associated with lower risk of HCC (HR, 0.62; 95% CI: 0.47-0.84; P trend = 0.0002) and lower risk of CLD mortality (HR, 0.52; 95% CI: 0.42-0.65; P trend < 0.0001). CONCLUSIONS: Adhering to dietary recommendations may reduce the risk of developing HCC and dying of CLD. SN - 1527-3350 UR - https://www.unboundmedicine.com/medline/citation/24715615/Index_based_dietary_patterns_and_risk_of_incident_hepatocellular_carcinoma_and_mortality_from_chronic_liver_disease_in_a_prospective_study_ L2 - https://doi.org/10.1002/hep.27160 DB - PRIME DP - Unbound Medicine ER -