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Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome.
Case Rep Med. 2014; 2014:830831.CR

Abstract

Cogan's syndrome (CS) is a chronic inflammatory disorder of unknown etiology that most commonly affects young adults. Clinical hallmarks are bilateral interstitial keratitis and vestibuloauditory dysfunction. Association between CS and systemic vasculitis as well as aortitis also exists. The diagnosis of CS is based upon presence of characteristic inflammatory eye disease and vestibuloauditory dysfunction. We describe classic Cogan's syndrome in a 47-year-old female from Ardabil. The patient was admitted with headache, vertigo, nausea, vomiting, right leg claudication, musculoskeletal pains, bilateral hearing loss, and blindness for the past two months. Ophthalmologic examination revealed that visual acuity was 0.1 bilaterally. Conjunctival hyperemia, bilateral cataract, and interstitial keratitis were detected with a slit lamp examination. Pure tone audiogram (PTA) and auditory brain stem response (ABR) showed bilateral sensorineural hearing loss. The other differential diagnosis of CS was studied and ruled out. Pulse i.v. methylprednisolone and cyclophosphamide were given and were followed by oral prednisolone and cyclophosphamide. Clinical follow-up showed partial improvement.

Authors+Show Affiliations

Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.Department of Internal Medicine, Shohadaye Khalije Fars Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24715922

Citation

Azami, Ahad, et al. "Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome." Case Reports in Medicine, vol. 2014, 2014, p. 830831.
Azami A, Maleki N, Kalantar Hormozi M, et al. Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. Case Rep Med. 2014;2014:830831.
Azami, A., Maleki, N., Kalantar Hormozi, M., & Tavosi, Z. (2014). Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. Case Reports in Medicine, 2014, 830831. https://doi.org/10.1155/2014/830831
Azami A, et al. Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. Case Rep Med. 2014;2014:830831. PubMed PMID: 24715922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. AU - Azami,Ahad, AU - Maleki,Nasrollah, AU - Kalantar Hormozi,Mohammadreza, AU - Tavosi,Zahra, Y1 - 2014/03/04/ PY - 2014/01/08/received PY - 2014/01/30/accepted PY - 2014/4/10/entrez PY - 2014/4/10/pubmed PY - 2014/4/10/medline SP - 830831 EP - 830831 JF - Case reports in medicine JO - Case Rep Med VL - 2014 N2 - Cogan's syndrome (CS) is a chronic inflammatory disorder of unknown etiology that most commonly affects young adults. Clinical hallmarks are bilateral interstitial keratitis and vestibuloauditory dysfunction. Association between CS and systemic vasculitis as well as aortitis also exists. The diagnosis of CS is based upon presence of characteristic inflammatory eye disease and vestibuloauditory dysfunction. We describe classic Cogan's syndrome in a 47-year-old female from Ardabil. The patient was admitted with headache, vertigo, nausea, vomiting, right leg claudication, musculoskeletal pains, bilateral hearing loss, and blindness for the past two months. Ophthalmologic examination revealed that visual acuity was 0.1 bilaterally. Conjunctival hyperemia, bilateral cataract, and interstitial keratitis were detected with a slit lamp examination. Pure tone audiogram (PTA) and auditory brain stem response (ABR) showed bilateral sensorineural hearing loss. The other differential diagnosis of CS was studied and ruled out. Pulse i.v. methylprednisolone and cyclophosphamide were given and were followed by oral prednisolone and cyclophosphamide. Clinical follow-up showed partial improvement. SN - 1687-9627 UR - https://www.unboundmedicine.com/medline/citation/24715922/Interstitial_Keratitis_Vertigo_and_Vasculitis:_Typical_Cogan's_Syndrome_ L2 - https://doi.org/10.1155/2014/830831 DB - PRIME DP - Unbound Medicine ER -
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