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Lack of effects of dietary folate intake on risk of breast cancer: an updated meta-analysis of prospective studies.
Asian Pac J Cancer Prev 2014; 15(5):2323-8AP

Abstract

BACKGROUND

Epidemiological findings are controversial relating to the relationship between dietary folate intake and the risk of breast cancer. We therefore conducted a meta-analysis of prospective cohort studies to clarify this association.

MATERIALS AND METHODS

PUPMED, EMBASE, and MEDLINE databases were searched for all relevant literature published in English from January 1, 1966 to August 2013. Summary relative risk (RR) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model.

RESULTS

Dietary folate intake was not significantly associated with the risk of breast cancer. The combined PR with 95% CI for the highest vs. lowest category dietary intake of folate [fifteen studies; 1,836,566 participants and 24,083 patients with breast cancer] was 0.98 (0.90-1.05). Among subgroup analysis by menstrual status, hormonal status and the consumption of alcohol, methionine and vitamin B12, no significant association was observed for the dietary intake of folate and the risk of breast cancer. Dose-response analysis showed that a 220 μg/day increment in dietary folate intake was not associated with the risk of breast cancer.

CONCLUSIONS

Our findings indicate that dietary folate intake has no significant effect on the risk of breast cancer.

Authors+Show Affiliations

Department of Public Health, Qingdao University, Qingdao, China E-mail : lianhuacui520@hanmail.net.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24716978

Citation

Liu, Meng, et al. "Lack of Effects of Dietary Folate Intake On Risk of Breast Cancer: an Updated Meta-analysis of Prospective Studies." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 5, 2014, pp. 2323-8.
Liu M, Cui LH, Ma AG, et al. Lack of effects of dietary folate intake on risk of breast cancer: an updated meta-analysis of prospective studies. Asian Pac J Cancer Prev. 2014;15(5):2323-8.
Liu, M., Cui, L. H., Ma, A. G., Li, N., & Piao, J. M. (2014). Lack of effects of dietary folate intake on risk of breast cancer: an updated meta-analysis of prospective studies. Asian Pacific Journal of Cancer Prevention : APJCP, 15(5), pp. 2323-8.
Liu M, et al. Lack of Effects of Dietary Folate Intake On Risk of Breast Cancer: an Updated Meta-analysis of Prospective Studies. Asian Pac J Cancer Prev. 2014;15(5):2323-8. PubMed PMID: 24716978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effects of dietary folate intake on risk of breast cancer: an updated meta-analysis of prospective studies. AU - Liu,Meng, AU - Cui,Lian-Hua, AU - Ma,Ai-Guo, AU - Li,Na, AU - Piao,Jin-Mei, PY - 2014/4/11/entrez PY - 2014/4/11/pubmed PY - 2014/12/17/medline SP - 2323 EP - 8 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 5 N2 - BACKGROUND: Epidemiological findings are controversial relating to the relationship between dietary folate intake and the risk of breast cancer. We therefore conducted a meta-analysis of prospective cohort studies to clarify this association. MATERIALS AND METHODS: PUPMED, EMBASE, and MEDLINE databases were searched for all relevant literature published in English from January 1, 1966 to August 2013. Summary relative risk (RR) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. RESULTS: Dietary folate intake was not significantly associated with the risk of breast cancer. The combined PR with 95% CI for the highest vs. lowest category dietary intake of folate [fifteen studies; 1,836,566 participants and 24,083 patients with breast cancer] was 0.98 (0.90-1.05). Among subgroup analysis by menstrual status, hormonal status and the consumption of alcohol, methionine and vitamin B12, no significant association was observed for the dietary intake of folate and the risk of breast cancer. Dose-response analysis showed that a 220 μg/day increment in dietary folate intake was not associated with the risk of breast cancer. CONCLUSIONS: Our findings indicate that dietary folate intake has no significant effect on the risk of breast cancer. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/24716978/Lack_of_effects_of_dietary_folate_intake_on_risk_of_breast_cancer:_an_updated_meta_analysis_of_prospective_studies_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:24716978&key=2014.15.5.2323 DB - PRIME DP - Unbound Medicine ER -