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Poor lung function has inverse relationship with microalbuminuria, an early surrogate marker of kidney damage and atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey.

Abstract

BACKGROUND

Despite epidemiological evidences of relationship between poor lung function and atherosclerosis, the relationship between poor lung function and microalbuminuria (MAU), an early surrogate marker of both kidney damage and atherosclerosis, is not well understood. Hence, we plan to investigate the relationship between poor lung function and MAU using multivariate models to adjust for other atherogenic risk factors.

METHODS

We used data from the 5th Korean National Health and Nutrition Examination Survey. Poor lung function is determined by spirometric measurement, primarily through estimation of the forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). Declines in the percent predicted FVC (<80%) and in the FEV1/FVC ratio (<0.7) are defined as restrictive and obstructive patterns, respectively. Urine albumin to urine creatinine levels ratio (UACR) were measured in spot urine samples. MAU was defined as UACR >30 mg/g.

RESULTS

Inverse relationship was observed between lung function and UACR. In an age-adjusted regression model, the regression coefficient (B) of 10% lower FVC was 11.09 in men (P = 0.002), which remained significant after adjustment for SBP, FBG, triglyceride level, BMI, smoking history, and heavy alcohol consumption (B = 7.52, P = 0.043). When the restrictive pattern was compared to the normal pattern, the odds ratios (OR) (95% confidence interval, 95%CI) for MAU were 1.90 (1.32-2.72) in men, after adjustment for age, hypertension, diabetes mellitus, triglyceride level, obesity, smoking history, physical activity, and heavy alcohol consumption.

CONCLUSIONS

Our study, the first investigation in Asia, demonstrated that the restrictive pattern is related to MAU in men. Furthermore, there was linear relationship between lower FVC and UACR. Thus, our current study suggests that poor lung function, particularly the restrictive pattern, is related to kidney damage as well as atherosclerosis.

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  • Authors+Show Affiliations

    ,

    The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Korea; Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea; Graduate School of Public Health, Yonsei University College of Medicine, Seoul, Korea.

    ,

    The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Korea; Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea; Graduate School of Public Health, Yonsei University College of Medicine, Seoul, Korea.

    ,

    Department of Occupational and Environmental Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

    The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Korea; Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea; Graduate School of Public Health, Yonsei University College of Medicine, Seoul, Korea.

    Source

    PloS one 9:4 2014 pg e94125

    MeSH

    Age Factors
    Aged
    Albuminuria
    Alcoholism
    Atherosclerosis
    Biomarkers
    Cardiovascular Diseases
    Comorbidity
    Creatinine
    Diabetes Mellitus
    Female
    Forced Expiratory Volume
    Humans
    Hypertriglyceridemia
    Kidney Diseases
    Lung
    Male
    Middle Aged
    Motor Activity
    Nutrition Surveys
    Overweight
    Republic of Korea
    Smoking
    Spirometry
    Vital Capacity

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24718679

    Citation

    Yoon, Jin-Ha, et al. "Poor Lung Function Has Inverse Relationship With Microalbuminuria, an Early Surrogate Marker of Kidney Damage and Atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey." PloS One, vol. 9, no. 4, 2014, pp. e94125.
    Yoon JH, Won JU, Ahn YS, et al. Poor lung function has inverse relationship with microalbuminuria, an early surrogate marker of kidney damage and atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey. PLoS ONE. 2014;9(4):e94125.
    Yoon, J. H., Won, J. U., Ahn, Y. S., & Roh, J. (2014). Poor lung function has inverse relationship with microalbuminuria, an early surrogate marker of kidney damage and atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey. PloS One, 9(4), pp. e94125. doi:10.1371/journal.pone.0094125.
    Yoon JH, et al. Poor Lung Function Has Inverse Relationship With Microalbuminuria, an Early Surrogate Marker of Kidney Damage and Atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey. PLoS ONE. 2014;9(4):e94125. PubMed PMID: 24718679.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Poor lung function has inverse relationship with microalbuminuria, an early surrogate marker of kidney damage and atherosclerosis: the 5th Korea National Health and Nutrition Examination Survey. AU - Yoon,Jin-Ha, AU - Won,Jong-Uk, AU - Ahn,Yeon-Soon, AU - Roh,Jaehoon, Y1 - 2014/04/09/ PY - 2014/01/23/received PY - 2014/03/12/accepted PY - 2014/4/11/entrez PY - 2014/4/11/pubmed PY - 2015/6/17/medline SP - e94125 EP - e94125 JF - PloS one JO - PLoS ONE VL - 9 IS - 4 N2 - BACKGROUND: Despite epidemiological evidences of relationship between poor lung function and atherosclerosis, the relationship between poor lung function and microalbuminuria (MAU), an early surrogate marker of both kidney damage and atherosclerosis, is not well understood. Hence, we plan to investigate the relationship between poor lung function and MAU using multivariate models to adjust for other atherogenic risk factors. METHODS: We used data from the 5th Korean National Health and Nutrition Examination Survey. Poor lung function is determined by spirometric measurement, primarily through estimation of the forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). Declines in the percent predicted FVC (<80%) and in the FEV1/FVC ratio (<0.7) are defined as restrictive and obstructive patterns, respectively. Urine albumin to urine creatinine levels ratio (UACR) were measured in spot urine samples. MAU was defined as UACR >30 mg/g. RESULTS: Inverse relationship was observed between lung function and UACR. In an age-adjusted regression model, the regression coefficient (B) of 10% lower FVC was 11.09 in men (P = 0.002), which remained significant after adjustment for SBP, FBG, triglyceride level, BMI, smoking history, and heavy alcohol consumption (B = 7.52, P = 0.043). When the restrictive pattern was compared to the normal pattern, the odds ratios (OR) (95% confidence interval, 95%CI) for MAU were 1.90 (1.32-2.72) in men, after adjustment for age, hypertension, diabetes mellitus, triglyceride level, obesity, smoking history, physical activity, and heavy alcohol consumption. CONCLUSIONS: Our study, the first investigation in Asia, demonstrated that the restrictive pattern is related to MAU in men. Furthermore, there was linear relationship between lower FVC and UACR. Thus, our current study suggests that poor lung function, particularly the restrictive pattern, is related to kidney damage as well as atherosclerosis. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24718679/Poor_lung_function_has_inverse_relationship_with_microalbuminuria_an_early_surrogate_marker_of_kidney_damage_and_atherosclerosis:_the_5th_Korea_National_Health_and_Nutrition_Examination_Survey_ L2 - http://dx.plos.org/10.1371/journal.pone.0094125 DB - PRIME DP - Unbound Medicine ER -