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Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia.
Alzheimers Dement 2015; 11(4):434-443.e6AD

Abstract

BACKGROUND

Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics.

METHODS

We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CAIDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559).

RESULTS

Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08-1.99) and low levels of midlife LTPA (HR, 1.39; 95% CI, 0.99-1.95) were associated with higher risk of dementia in comparison with the most active category. The benefits were more pronounced among men, overweight individuals, and APOE ε4 noncarriers. Maintaining high LTPA (HR, 0.16; 95% CI, 0.06-0.41) or increasing LTPA (HR, 0.19; 95% CI, 0.09-0.40) after midlife was associated with lower dementia risk. Similar results were observed for AD.

CONCLUSIONS

The window of opportunity for preventive physical activity interventions may extend from midlife to older ages.

Authors+Show Affiliations

Department of Neurology, University of Eastern Finland, Kuopio, Finland. Electronic address: anna-maija.tolppanen@uef.fi.Department of Neurology, University of Eastern Finland, Kuopio, Finland; Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden; Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.Gerontology Research Center, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden; Institute for Gerontology, School of Health Sciences, Jönköping University, Jönköping, Sweden.Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.Department of Neurology, University of Eastern Finland, Kuopio, Finland.Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Hospital District of North Karelia, Joensuu, Finland.Department of Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.Department of Neurology, University of Eastern Finland, Kuopio, Finland; Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden; Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24721528

Citation

Tolppanen, Anna-Maija, et al. "Leisure-time Physical Activity From Mid- to Late Life, Body Mass Index, and Risk of Dementia." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 11, no. 4, 2015, pp. 434-443.e6.
Tolppanen AM, Solomon A, Kulmala J, et al. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. Alzheimers Dement. 2015;11(4):434-443.e6.
Tolppanen, A. M., Solomon, A., Kulmala, J., Kåreholt, I., Ngandu, T., Rusanen, M., ... Kivipelto, M. (2015). Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 11(4), pp. 434-443.e6. doi:10.1016/j.jalz.2014.01.008.
Tolppanen AM, et al. Leisure-time Physical Activity From Mid- to Late Life, Body Mass Index, and Risk of Dementia. Alzheimers Dement. 2015;11(4):434-443.e6. PubMed PMID: 24721528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. AU - Tolppanen,Anna-Maija, AU - Solomon,Alina, AU - Kulmala,Jenni, AU - Kåreholt,Ingemar, AU - Ngandu,Tiia, AU - Rusanen,Minna, AU - Laatikainen,Tiina, AU - Soininen,Hilkka, AU - Kivipelto,Miia, Y1 - 2014/04/08/ PY - 2013/10/23/received PY - 2014/01/02/revised PY - 2014/01/21/accepted PY - 2014/4/12/entrez PY - 2014/4/12/pubmed PY - 2015/12/25/medline KW - Cohort study KW - Dementia KW - Exercise KW - Life course KW - Obesity KW - Physical activity SP - 434 EP - 443.e6 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 11 IS - 4 N2 - BACKGROUND: Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics. METHODS: We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CAIDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559). RESULTS: Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08-1.99) and low levels of midlife LTPA (HR, 1.39; 95% CI, 0.99-1.95) were associated with higher risk of dementia in comparison with the most active category. The benefits were more pronounced among men, overweight individuals, and APOE ε4 noncarriers. Maintaining high LTPA (HR, 0.16; 95% CI, 0.06-0.41) or increasing LTPA (HR, 0.19; 95% CI, 0.09-0.40) after midlife was associated with lower dementia risk. Similar results were observed for AD. CONCLUSIONS: The window of opportunity for preventive physical activity interventions may extend from midlife to older ages. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/24721528/Leisure_time_physical_activity_from_mid__to_late_life_body_mass_index_and_risk_of_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(14)00034-X DB - PRIME DP - Unbound Medicine ER -